Biomedical CARS system free of external delay line

Tigran Mansuryan; Alessandro Tonello; Katarzyna Krupa; Alexis Desmoulière; Mark Arthur Ndong Ntoutoume; Vincent Sol; Claire Lefort; Mario Zitelli; Mario Ferraro; Fabio Mangini; Yifan Sun; Yago Arosa; Benjamin Wetzel; Stefan Wabnitz; Vincent Couderc

doi:10.1117/12.3016653

20 June 2024 Biomedical CARS system free of external delay line

Tigran Mansuryan, Alessandro Tonello, Katarzyna Krupa, Alexis Desmoulière, Mark Arthur Ndong Ntoutoume, Vincent Sol, Claire Lefort, Mario Zitelli, Mario Ferraro, Fabio Mangini, Yifan Sun, Yago Arosa, Benjamin Wetzel, Stefan Wabnitz, Vincent Couderc

Author Affiliations +

Proceedings Volume PC13006, Biomedical Spectroscopy, Microscopy, and Imaging III; PC1300601 (2024) https://doi.org/10.1117/12.3016653
Event: SPIE Photonics Europe, 2024, Strasbourg, France

Abstract

Multiplex Coherent Anti-Stokes Raman Scattering (M-CARS) is an innovative nonlinear spectroscopic approach designed to characterize the vibrational modes of molecular structures. Coherent Raman scattering has been used for the characterization of biomedical targets for about 20 years and the multiplex aspect was introduced 10 years ago thanks to the use of a supercontinuum laser system. For each of these systems, the combination of a pump and a probe wave, driven by an external delay line, is however required to produce the vibrations. In the present work, we propose a new M-CARS system, free of the external delay line. A few-mode microstructured fiber enables merging both wave-packets (pump and supercontinuum) within a single waveguide. We showcase the capability of this system in generating hyperspectral images of biochemically active compounds. Curcumin I, the principal yellow compound isolated from Curcuma longa (Turmeric), is distinguishable by its multiple functional groups that display a nonlinear spectroscopic behavior.

Conference Presentation

Citation Download Citation

Tigran Mansuryan, Alessandro Tonello, Katarzyna Krupa, Alexis Desmoulière, Mark Arthur Ndong Ntoutoume, Vincent Sol, Claire Lefort, Mario Zitelli, Mario Ferraro, Fabio Mangini, Yifan Sun, Yago Arosa, Benjamin Wetzel, Stefan Wabnitz, and Vincent Couderc "Biomedical CARS system free of external delay line", Proc. SPIE PC13006, Biomedical Spectroscopy, Microscopy, and Imaging III, PC1300601 (20 June 2024); https://doi.org/10.1117/12.3016653

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