Development and Field Validation of an End-User Photo-Thermal Device for Accurate Detection and Quantification of Analytes in Fluidic Samples

Derek Hayden; Baseer Yousufzai; Nima Tabatabaei

doi:10.1117/12.3017106

20 June 2024 Development and Field Validation of an End-User Photo-Thermal Device for Accurate Detection and Quantification of Analytes in Fluidic Samples

Derek Hayden, Baseer Yousufzai, Nima Tabatabaei

Author Affiliations +

Proceedings Volume PC13008, Biophotonics in Point-of-Care III; PC1300801 (2024) https://doi.org/10.1117/12.3017106
Event: SPIE Photonics Europe, 2024, Strasbourg, France

Abstract

While paper-based rapid tests are abundantly used in medicine, their performance is limited by the poor limit of detection and binary response of the test. We have previously shown that interpreting rapid tests based on laser-induced photothermal responses can offer over an order magnitude improvement in test performance. This work reports on miniaturization of our photothermal sensing paradigm in a low-cost handheld device and its field validations. The hand-held device excites assay gold nanoparticles with a modulated, low-power LED while recording their thermal wave responses with low-cost single-element sensors. An Arduino-based processor demodulates thermal wave responses while offering internet-of-things capability. Results from a human study on detection and quantification of Cannabis consumption will also be presented and discussed.

Conference Presentation

Citation Download Citation

Derek Hayden, Baseer Yousufzai, and Nima Tabatabaei "Development and Field Validation of an End-User Photo-Thermal Device for Accurate Detection and Quantification of Analytes in Fluidic Samples", Proc. SPIE PC13008, Biophotonics in Point-of-Care III, PC1300801 (20 June 2024); https://doi.org/10.1117/12.3017106

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