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Field Guide to Optical Biosensing
Author(s): Raúl J. Martín-Palma
Published: 2021
https://doi.org/10.1117/3.2575468
PDF ISBN: 9781510638600 | Print ISBN: 9781510638594
TABLE OF CONTENTS
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Front Matter
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Motivation
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What Is a Biosensor?
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Elements of a Biosensor
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Example: Immunochromatographic Assays
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Non-optical Biosensors
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Optical Biosensors
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History of Biosensors
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Early Milestones in the Development of Biosensors
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Later Milestones in the Development of Biosensors
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Immobilization of Bioreceptors
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From Surface Functionalization to Analyte Capture
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Common Bioreceptors
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More Bioreceptors
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Usual Methods of Immobilization
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Precision and Accuracy
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Repeatability, Reproducibility, and Selectivity
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Sensitivity
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Measurand, Full-Scale, and Dynamic Ranges
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Signal-to-Noise Ratio
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Minimum Detectable Signal and Saturation
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Time Factors and Stability
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Resolution, Threshold, Calibration, and Hysteresis
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Linearity, Offset, and Overload
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Deviations from Ideality (Errors)
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The Ideal Biosensor
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Fundamental Optical Processes
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Transmission, Absorption, and Scattering
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Optical Phase Difference and Optical Path Difference
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Polarization
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Surface Plasmon Resonance
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Luminescence
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Photoluminescence
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Fluorescence
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Phosphorescence
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Fluorescence Polarization
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Absorbance Biosensors
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Infrared Spectroscopy
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Infrared Vibrational Modes
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Scattering Detection
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Resonance Rayleigh Scattering
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Transduction Based on Reflectance and Transmittance
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Interferometric Biosensors
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Colorimetric Bioassays
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Biosensing Using Ellipsometry
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Photonic Crystals
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Fluorescence-Based Biosensing
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Fluorescence Polarization Detection
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Phosphorescence-Based Biosensing
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Chemiluminescence
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Bioluminescence
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Time-Resolved Fluorescence
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Evanescent Wave Biosensing
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Attenuated Total Reflection Spectroscopy
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Fiber-Optic Biosensors
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Near-Field Scanning Optical Microscopy
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Surface Plasmon Resonance Biosensors
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Real-Time SPR Sensing
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Phase-Sensitive Biosensing
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Optical Heterodyne Detection
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Polarimetry
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Photoacoustic Spectroscopy
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Raman Spectroscopy
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Surface-Enhanced Raman Scattering Detection
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Planar Optical Waveguides and Integrated Optical Sensors
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Waveguide Interferometer Architectures
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Mach–Zehnder Interferometer
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Young Interferometer
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Hartmann Interferometer
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Dual Polarization Interferometry
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Bimodal Waveguide Interferometers
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Resonant Waveguide Grating
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Antiresonant Reflecting Optical Waveguides
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Hollow Waveguides
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Photonic Crystal Cavity Biosensors
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Resonant Optical Microcavities
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Beyond the Visible and Infrared Ranges
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Integrated Microfluidic Biosensors
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Lab-on-a-Chip Devices
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Bioimaging
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Medicine
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Infections Caused by Pathogens
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Airborne Diseases
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Point-of-Care Testing Techniques
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Home Monitoring
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Optical Biosensors for Therapeutic Drug Monitoring
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Food Safety
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Common Foodborne Pathogens
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Food Industry
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Biosensors for the Detection of Foodborne Pathogens
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Defense
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Important Biological Warfare Agents
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Some Optical Biosensors for Biological Warfare Agents
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Homeland Security
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Environmental Applications
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Wearable and Implantable Biosensors
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Challenges in Biosensor Commercialization
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Equation Summary
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Back Matter
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