In vivo determination of skin near-infrared optical properties using diffuse optical spectroscopy

Sheng-Hao Tseng; Alexander Grant; Anthony Joseph Durkin

doi:10.1117/1.2829772

1 January 2008 In vivo determination of skin near-infrared optical properties using diffuse optical spectroscopy

Sheng-Hao Tseng, Alexander Grant, Anthony Joseph Durkin

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Journal of Biomedical Optics, Vol. 13, Issue 1, 014016 (January 2008). https://doi.org/10.1117/1.2829772

Abstract

We develop a superficial diffusing probe with a 3 mm source-detector separation that can be used in combination with diffuse optical spectroscopic (DOS) methods to noninvasively determine full-spectrum optical properties of superficial in vivo skin in the wavelength range from 650 to 1000 nm. This new probe uses a highly scattering layer to diffuse photons emitted from a collimated light source and relies on a two-layer diffusion model to determine tissue absorption coefficient μ_a and reduced scattering coefficient μ_s′. By employing the probe to measure two-layer phantoms that mimic the optical properties of skin, we demonstrate that the probe has an interrogation depth of 1 to 2 mm. We carry out SSFDPM (steady state frequency-domain photon migration) measurements using this new probe on the volar forearm and palm of 15 subjects, including five subjects of African descent, five Asians, and five Caucasians. The optical properties of in vivo skin determined using the superficial diffusing probe show considerable similarity to published optical properties of carefully prepared ex vivo epidermis+dermis.

©(2008) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Sheng-Hao Tseng, Alexander Grant, and Anthony Joseph Durkin "In vivo determination of skin near-infrared optical properties using diffuse optical spectroscopy," Journal of Biomedical Optics 13(1), 014016 (1 January 2008). https://doi.org/10.1117/1.2829772

Published: 1 January 2008

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