Enhanced optical clearing of skin in vivo and optical coherence tomography in-depth imaging

Xiang Wen; Steven L. Jacques; Valery V. Tuchin; Dan Zhu

doi:10.1117/1.JBO.17.6.066022

13 June 2012 Enhanced optical clearing of skin in vivo and optical coherence tomography in-depth imaging

Xiang Wen, Steven L. Jacques, Valery V. Tuchin, Dan Zhu

Author Affiliations +

Journal of Biomedical Optics, Vol. 17, Issue 6, 066022 (June 2012). https://doi.org/10.1117/1.JBO.17.6.066022

Abstract

The strong optical scattering of skin tissue makes it very difficult for optical coherence tomography (OCT) to achieve deep imaging in skin. Significant optical clearing of in vivo rat skin sites was achieved within 15 min by topical application of an optical clearing agent PEG-400, a chemical enhancer (thiazone or propanediol), and physical massage. Only when all three components were applied together could a 15 min treatment achieve a three fold increase in the OCT reflectance from a 300 μm depth and 31% enhancement in image depth Z_threshold.

Citation Download Citation

Xiang Wen, Steven L. Jacques, Valery V. Tuchin, and Dan Zhu "Enhanced optical clearing of skin in vivo and optical coherence tomography in-depth imaging," Journal of Biomedical Optics 17(6), 066022 (13 June 2012). https://doi.org/10.1117/1.JBO.17.6.066022

Received: 16 November 2011; Accepted: 17 April 2012; Published: 13 June 2012

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
6 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY