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28 November 2017 Long ranging swept-source optical coherence tomography-based angiography outperforms its spectral-domain counterpart in imaging human skin microcirculations
Jingjiang Xu, Shaozhen Song, Shaojie Men, Ruikang K. Wang
Author Affiliations +
Funded by: National Heart, Lung, and Blood Institute, National Institutes of Health, National Heart, Lung, and Blood Institute (NHBLI), National Eye Institute, National Eye Institute (NEI)
Journal of Biomedical Optics, Vol. 22, Issue 11, 116007 (November 2017). https://doi.org/10.1117/1.JBO.22.11.116007
Abstract
There is an increasing demand for imaging tools in clinical dermatology that can perform in vivo wide-field morphological and functional examination from surface to deep tissue regions at various skin sites of the human body. The conventional spectral-domain optical coherence tomography-based angiography (SD-OCTA) system is difficult to meet these requirements due to its fundamental limitations of the sensitivity roll-off, imaging range as well as imaging speed. To mitigate these issues, we demonstrate a swept-source OCTA (SS-OCTA) system by employing a swept source based on a vertical cavity surface-emitting laser. A series of comparisons between SS-OCTA and SD-OCTA are conducted. Benefiting from the high system sensitivity, long imaging range, and superior roll-off performance, the SS-OCTA system is demonstrated with better performance in imaging human skin than the SD-OCTA system. We show that the SS-OCTA permits remarkable deep visualization of both structure and vasculature (up to ∼2  mm penetration) with wide field of view capability (up to 18×18  mm2), enabling a more comprehensive assessment of the morphological features as well as functional blood vessel networks from the superficial epidermal to deep dermal layers. It is expected that the advantages of the SS-OCTA system will provide a ground for clinical translation, benefiting the existing dermatological practice.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE) 1083-3668/2017/$25.00 © 2017 SPIE
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Jingjiang Xu, Shaozhen Song, Shaojie Men, and Ruikang K. Wang "Long ranging swept-source optical coherence tomography-based angiography outperforms its spectral-domain counterpart in imaging human skin microcirculations," Journal of Biomedical Optics 22(11), 116007 (28 November 2017). https://doi.org/10.1117/1.JBO.22.11.116007
Received: 14 September 2017; Accepted: 8 November 2017; Published: 28 November 2017
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KEYWORDS
Imaging systems
Skin
Optical coherence tomography
Tissue optics
Visualization
Coherence (optics)
Ranging
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