CONFERENCE PROCEEDINGS
Advanced Search
Home > Journals > J. Biomed. Opt. > Volume 23 > Issue 3 > Article
Open Access
5 March 2018 Volumetric imaging of rod and cone photoreceptor structure with a combined adaptive optics-optical coherence tomography-scanning laser ophthalmoscope
Elaine M. M. Wells-Gray, Stacey S. Choi, Robert J. Zawadzki, Susanna C. Finn, Cherry A. Greiner, John S. Werner, Nathan P. Doble
Author Affiliations +
Journal of Biomedical Optics, Vol. 23, Issue 3, 036003 (March 2018). https://doi.org/10.1117/1.JBO.23.3.036003
Abstract
We have designed and implemented a dual-mode adaptive optics (AO) imaging system that combines spectral domain optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO) for in vivo imaging of the human retina. The system simultaneously acquires SLO frames and OCT B-scans at 60 Hz with an OCT volume acquisition time of 4.2 s. Transverse eye motion measured from the SLO is used to register the OCT B-scans to generate three-dimensional (3-D) volumes. Key optical design considerations include: minimizing system aberrations through the use of off-axis relay telescopes, conjugate pupil plane requirements, and the use of dichroic beam splitters to separate and recombine the OCT and SLO beams around the nonshared horizontal scanning mirrors. To demonstrate system performance, AO-OCT-SLO images and measurements are taken from three normal human subjects ranging in retinal eccentricity from the fovea out to 15-deg temporal and 20-deg superior. Also presented are en face OCT projections generated from the registered 3-D volumes. The ability to acquire high-resolution 3-D images of the human retina in the midperiphery and beyond has clinical importance in diseases, such as retinitis pigmentosa and cone–rod dystrophy.
© 2018 Society of Photo-Optical Instrumentation Engineers (SPIE) 1083-3668/2018/$25.00 © 2018 SPIE
Citation Download Citation
Elaine M. M. Wells-Gray, Stacey S. Choi, Robert J. Zawadzki, Susanna C. Finn, Cherry A. Greiner, John S. Werner, and Nathan P. Doble "Volumetric imaging of rod and cone photoreceptor structure with a combined adaptive optics-optical coherence tomography-scanning laser ophthalmoscope," Journal of Biomedical Optics 23(3), 036003 (5 March 2018). https://doi.org/10.1117/1.JBO.23.3.036003
Received: 30 October 2017; Accepted: 29 January 2018; Published: 5 March 2018
JOURNAL ARTICLE
 15 PAGES
DOWNLOAD PAPER SAVE TO MY LIBRARY
GET CITATION
Lens.org Logo
CITATIONS
Cited by 22 scholarly publications.
Advertisement
Advertisement
RIGHTS & PERMISSIONS
Get copyright permission  Get copyright permission on Copyright Marketplace
KEYWORDS
Optical coherence tomography
Scanning laser ophthalmoscopy
Cones
Eye
Adaptive optics optical coherence tomography
Rods
Adaptive optics
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top