Magnetic resonance imaging preprocessing and radiomic features for classification of autosomal dominant polycystic kidney disease genotype

Linnea E. Kremer; Arlene B. Chapman; Samuel G. Armato III

doi:10.1117/1.JMI.10.6.064503

27 December 2023 Magnetic resonance imaging preprocessing and radiomic features for classification of autosomal dominant polycystic kidney disease genotype

Linnea E. Kremer, Arlene B. Chapman, Samuel G. Armato III

Author Affiliations +

Journal of Medical Imaging, Vol. 10, Issue 6, 064503 (December 2023). https://doi.org/10.1117/1.JMI.10.6.064503

Abstract

Purpose

Our study aims to investigate the impact of preprocessing on magnetic resonance imaging (MRI) radiomic features extracted from the noncystic kidney parenchyma of patients with autosomal dominant polycystic kidney disease (ADPKD) in the task of classifying PKD1 versus PKD2 genotypes, which differ with regard to cyst burden and disease outcome.

Approach

The effect of preprocessing on radiomic features was investigated using a single T2-weighted fat saturated (T2W-FS) MRI scan from PKD1 and PKD2 subjects (29 kidneys in total) from the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease study. Radiomic feature reproducibility using the intraclass correlation coefficient (ICC) was computed across MRI normalizations (z-score, reference-tissue, and original image), gray-level discretization, and upsampling and downsampling pixel schemes. A second dataset for genotype classification from 136 subjects T2W-FS MRI images previously enrolled in the HALT Progression of Polycystic Kidney Disease study was matched for age, gender, and Mayo imaging classification class. Genotype classification was performed using a logistic regression classifier and radiomic features extracted from (1) the noncystic kidney parenchyma and (2) the entire kidney. The area under the receiver operating characteristic curve (AUC) was used to evaluate the classification performance across preprocessing methods.

Results

Radiomic features extracted from the noncystic kidney parenchyma were sensitive to preprocessing parameters, with varying reproducibility depending on the parameter. The percentage of features with good-to-excellent ICC scores ranged from 14% to 58%. AUC values ranged between 0.47 to 0.68 and 0.56 to 0.73 for the noncystic kidney parenchyma and entire kidney, respectively.

Conclusions

Reproducibility of radiomic features extracted from the noncystic kidney parenchyma was dependent on the preprocessing parameters used, and the effect on genotype classification was sensitive to preprocessing parameters. The results suggest that texture features may be indicative of genotype expression in ADPKD.

Citation Download Citation

Linnea E. Kremer, Arlene B. Chapman, and Samuel G. Armato III "Magnetic resonance imaging preprocessing and radiomic features for classification of autosomal dominant polycystic kidney disease genotype," Journal of Medical Imaging 10(6), 064503 (27 December 2023). https://doi.org/10.1117/1.JMI.10.6.064503

Received: 22 June 2023; Accepted: 28 November 2023; Published: 27 December 2023

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KEYWORDS

Kidney

Magnetic resonance imaging

Radiomics

Feature extraction

Reproducibility

Diseases and disorders

Signal intensity

Purpose

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