Resonance plasmonic gold microwell arrays for high-performance surface plasmon resonance imaging based on polarization contrast modulation

Yi Sun; Haoyuan Cai; Xiaoping Wang

doi:10.1117/1.JNP.13.012507

16 November 2018 Resonance plasmonic gold microwell arrays for high-performance surface plasmon resonance imaging based on polarization contrast modulation

Yi Sun, Haoyuan Cai, Xiaoping Wang

Author Affiliations +

Journal of Nanophotonics, Vol. 13, Issue 1, 012507 (November 2018). https://doi.org/10.1117/1.JNP.13.012507

Abstract

The throughput and label-free multianalyte interrogation ability provided by surface plasmon resonance imaging (SPRi) sensors has gained considerable interest in biochemical analysis. Here, we report an optical platform based on polarization contrast modulation, in which a three-dimensional plasmonic microwell array is used as a sensing chip to eliminate background resonance and greatly enhance the electromagnetic field response in the microwell structure by confining the SPR. In addition, the sensor can provide an extremely high contrast and signal-to-noise ratio and can achieve a very high sensitivity response (1.52 × 10⁵ pixel / RIU). Additionally, the signal-to-background ratio is improved to 40. The low-concentration limit of detection can reach 5.38 × 10^− 7 RIU, which is 1 order of magnitude improvement. In biomolecular interaction analysis, the sensor can detect a 5.12 × 10⁴-fold diluted bovine serum albumin antibody solution. The special chip architecture and high image quality introduce an array screening method using SPRi detection.

Citation Download Citation

Yi Sun, Haoyuan Cai, and Xiaoping Wang "Resonance plasmonic gold microwell arrays for high-performance surface plasmon resonance imaging based on polarization contrast modulation," Journal of Nanophotonics 13(1), 012507 (16 November 2018). https://doi.org/10.1117/1.JNP.13.012507

Received: 18 June 2018; Accepted: 24 October 2018; Published: 16 November 2018

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available