Toward peripheral nerve mechanical characterization using Brillouin imaging spectroscopy

Vsevolod Cheburkanov; Junwei Du; David Brogan; Mikhail Y. Berezin; Vladislav V. Yakovlev

doi:10.1117/1.NPh.10.3.035007

26 August 2023 Toward peripheral nerve mechanical characterization using Brillouin imaging spectroscopy

Vsevolod Cheburkanov, Junwei Du, David Brogan, Mikhail Y. Berezin, Vladislav V. Yakovlev

Author Affiliations +

Neurophotonics, Vol. 10, Issue 3, 035007 (August 2023). https://doi.org/10.1117/1.NPh.10.3.035007

Abstract

Significance

Peripheral nerves are viscoelastic tissues with unique elastic characteristics. Imaging of peripheral nerve elasticity is important in medicine, particularly in the context of nerve injury and repair. Elasticity imaging techniques provide information about the mechanical properties of peripheral nerves, which can be useful in identifying areas of nerve damage or compression, as well as assessing the success of nerve repair procedures.

Aim

We aim to assess the feasibility of Brillouin microspectroscopy for peripheral nerve imaging of elasticity, with the ultimate goal of developing a new diagnostic tool for peripheral nerve injury in vivo.

Approach

Viscoelastic properties of the peripheral nerve were evaluated with Brillouin imaging spectroscopy.

Results

An external stress exerted on the fixed nerve resulted in a Brillouin shift. Quantification of the shift enabled correlation of the Brillouin parameters with nerve elastic properties.

Conclusions

Brillouin microscopy provides sufficient sensitivity to assess viscoelastic properties of peripheral nerves.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

Citation Download Citation

Vsevolod Cheburkanov, Junwei Du, David Brogan, Mikhail Y. Berezin, and Vladislav V. Yakovlev "Toward peripheral nerve mechanical characterization using Brillouin imaging spectroscopy," Neurophotonics 10(3), 035007 (26 August 2023). https://doi.org/10.1117/1.NPh.10.3.035007

Received: 24 April 2023; Accepted: 9 August 2023; Published: 26 August 2023

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