Discrimination of chemical warfare simulants via multiplex coherent anti-Stokes Raman scattering and multivariate statistical analysis

John J. Brady; Mikella E. Farrell; Paul M. Pellegrino

doi:10.1117/1.OE.53.2.021105

25 September 2013 Discrimination of chemical warfare simulants via multiplex coherent anti-Stokes Raman scattering and multivariate statistical analysis

John J. Brady, Mikella E. Farrell, Paul M. Pellegrino

Author Affiliations +

Optical Engineering, Vol. 53, Issue 2, 021105 (September 2013). https://doi.org/10.1117/1.OE.53.2.021105

Abstract

Multiplex coherent anti-Stokes Raman scattering (MCARS) is used to detect several chemical warfare simulants, such as dimethyl methylphosphonate and 2-chloroethyl ethyl sulfide, with high specificity. The spectral bandwidth of the femtosecond laser pulse used in these studies is sufficient to coherently and simultaneously drive all the vibrational modes in the molecule of interest. Evidence shows that MCARS is capable of overcoming common sensitivity limitations of spontaneous Raman scattering, thus allowing for the detection of the target material in milliseconds with standard, uncooled universal serial bus spectrometers as opposed to seconds with cooled, intensified CCD-based spectrometers. In addition, the obtained MCARS spectrum of the investigated sample provides multiple unique signatures. These signatures are used in an off-line multivariate statistical analysis allowing for the material’s discrimination with high fidelity.

Citation Download Citation

John J. Brady, Mikella E. Farrell, and Paul M. Pellegrino "Discrimination of chemical warfare simulants via multiplex coherent anti-Stokes Raman scattering and multivariate statistical analysis," Optical Engineering 53(2), 021105 (25 September 2013). https://doi.org/10.1117/1.OE.53.2.021105

Published: 25 September 2013

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available