In the field of the active wavefront correction for off-axis telescopes, the sensitivity matrix and damped least squares method are widely employed to calculate the misalignment. Improper selection of the damping coefficient will lead to bad wavefront correction results. Moreover, the calculated misalignment is referenced on the optical coordinate system, which cannot be directly applied as the control quantity. The article has two innovative points to solve these problems. First, an adaptive damping least squares method is proposed. The method considers the mirror surface error, uses Python + Zemax cosimulation to perform closed-loop reverse verification, and selects the optimal damping coefficient. Simulation is carried out for verification. Second, the article deduces the mathematical relationship between the calculated misalignment and the mechanism control quantity. Based on the above research, the wavefront active correction experiment has been completed. The optical component is actively adjusted with the wavefront quickly converging to RMS = 0 . 055λ @ 632 . 8 nm. The results verify the correctness of the proposed method.