Mr. Andrew G. Cabe Profile

Andrew G. Cabe

SPIE Involvement:

Author

Publications (1)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 4 March 2022 Presentation + Paper

A novel laser cutting and cooling system for crossing coronary chronic total occlusions

Nitesh Katta, Aleksandra Gruslova, Scott Jenney, Arnold Estrada, Andrew Cabe, Drew Nolen, Marc Feldman, Thomas Milner

Proceedings Volume 11936, 1193604 (2022) https://doi.org/10.1117/12.2610088

KEYWORDS: Arteries, Optical coherence tomography, Laser cutting, In vivo imaging, Tissues, Coronary catheterization, Carbon dioxide

Read Abstract +

Coronary chronic total occlusions (CTOs) are atherosclerotic plaques comprised of lipid, fibrous and hard calcific material that originate in the vessel wall and extend into the lumen, restricting luminal cross-section by 100% resulting in complete stoppage of blood flow in the affected artery for at least three months. Due to their structure and calcific composition, CTOs are very difficult to treat with existing percutaneous coronary interventional (PCI) techniques. CTOs frequently have a hard fibro-calcific cap on the proximal side with a softer lipidic composition in the interior and distal side. We constructed a novel catheter system with a fiber coupled Ho:YAG laser (2.1um, Coherent Inc) for cutting and a biocompatible CO₂ cooling system delivered through a 200um conduit for intravascular cooling. Laser radiation delivered a maximum average power of 20W corresponding to a pulse energy of 300mJ, pulse duration of 200μs, and a pulse repetition rate of 10Hz. Light emitted from the fiber was directed onto ex vivo suspect-calcified CTO arteries (n=3). Successful CTO crossing was achieved in all ex vivo samples. Histological processing showed greater than 50% reduction in residual thermal damage in crossed CTO regions with CO₂ cooling compared to no cooling. The miniature device was also used to cross CTOs in an in vivo rabbit femoral CTO model (n=4) under Xray fluoroscopy guidance and subsequent contrast angiography confirmed restoration of blood flow.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years