Dr. Bao-Yu Hsieh Profile

Dr. Bao-Yu Hsieh

at Univ of Washington

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Publications (5)

Proceedings Article | 19 February 2018 Paper

Dual-wavelength OR-PAM with compressed sensing for cell tracking in a 3D cell culture system

Rou-Xuan Huang, Ying Fu, Wang Liu, Yu-Ting Ma, Bao-Yu Hsieh, Shu-Ching Chen, Mingjian Sun, Pai-Chi Li

Proceedings Volume 10494, 1049462 (2018) https://doi.org/10.1117/12.2289975

KEYWORDS: Image restoration, 3D modeling, Photoacoustic spectroscopy, Compressed sensing, Tumors, Imaging systems, Optical microscopy, Laser irradiation, Optical spheres, 3D acquisition

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SPIE Journal Paper | 8 November 2016 Open Access

Moving-source elastic wave reconstruction for high-resolution optical coherence elastography

Bao-Yu Hsieh, Shaozhen Song, Thu-Mai Nguyen, Soon Joon Yoon, Tueng Shen, Ruikang Wang, Matthew O'Donnell

JBO, Vol. 21, Issue 11, 116006, (November 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.11.116006

KEYWORDS: Optical coherence tomography, Wave propagation, Crystals, Speckle, Tissues, Ultrasonography, Sensors, Coherence (optics), Elastography, Imaging systems

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Proceedings Article | 27 April 2016 Presentation

High speed all optical shear wave imaging optical coherence elastography (Conference Presentation)

Shaozhen Song, Bao-Yu Hsieh, Wei Wei, Tueng Shen, Matthew O'Donnell, Ruikang Wang

Proceedings Volume 9710, 97100B (2016) https://doi.org/10.1117/12.2211267

KEYWORDS: Elastography, Tissues, Coherence imaging, Optical coherence tomography, Soft tissue optics, Tissue optics, Coherence (optics), Optical imaging, Wave propagation, Imaging systems

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Proceedings Article | 9 March 2016 Presentation + Paper

Elasticity imaging of speckle-free tissue regions with moving acoustic radiation force and phase-sensitive optical coherence tomography

Bao-Yu Hsieh, Shaozhen Song, Thu-Mai Nguyen, Soon Joon Yoon, Tueng Shen, Ruikang Wang, Matthew O’Donnell

Proceedings Volume 9710, 97101F (2016) https://doi.org/10.1117/12.2211522

KEYWORDS: Acoustics, Crystals, Optical coherence tomography, Speckle imaging, Elastography, Speckle, Tissue optics, Crystal optics, Optical tracking, Ophthalmology, Wave propagation, Imaging systems, Ultrasonography

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Phase-sensitive optical coherence tomography (PhS-OCT) can be utilized for quantitative shear-wave elastography using speckle tracking. However, current approaches cannot directly reconstruct elastic properties in speckle-less or speckle-free regions, for example within the crystalline lens in ophthalmology. Investigating the elasticity of the crystalline lens could improve understanding and help manage presbyopia-related pathologies that change biomechanical properties. We propose to reconstruct the elastic properties in speckle-less regions by sequentially launching shear waves with moving acoustic radiation force (mARF), and then detecting the displacement at a specific speckle-generating position, or limited set of positions, with PhS-OCT. A linear ultrasound array (with a center frequency of 5 MHz) interfaced with a programmable imaging system was designed to launch shear waves by mARF. Acoustic sources were electronically translated to launch shear waves at laterally shifted positions, where displacements were detected by speckle tracking images produced by PhS-OCT operating in M-B mode with a 125-kHz A-line rate. Local displacements were calculated and stitched together sequentially based on the distance between the acoustic source and the detection beam. Shear wave speed, and the associated elasticity map, were then reconstructed based on a time-of-flight algorithm. In this study, moving-source shear wave elasticity imaging (SWEI) can highlight a stiff inclusion within an otherwise homogeneous phantom but with a CNR increased by 3.15 dB compared to a similar image reconstructed with moving-detector SWEI. Partial speckle-free phantoms were also investigated to demonstrate that the moving-source sequence could reconstruct the elastic properties of speckle-free regions. Results show that harder inclusions within the speckle-free region can be detected, suggesting that this imaging method may be able to detect the elastic properties of the crystalline lens.

Proceedings Article | 8 March 2016 Presentation + Paper

Optical coherence elastography based on high speed imaging of single-hot laser-induced acoustic waves at 16 kHz frame rate

Shaozhen Song, Bao-Yu Hsieh, Wei Wei, Tueng Shen, Ivan Pelivanov, Matthew O'Donnell, Ruikang Wang

Proceedings Volume 9697, 96971O (2016) https://doi.org/10.1117/12.2214809

KEYWORDS: Elastography, Optical coherence tomography, Imaging systems, Pulsed laser operation, Wave propagation, Ultraviolet radiation, Cornea

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