Clark Tibbetts, Agnieszka Lichanska, Lisa Borsuk, Brian Weslowski, Leah Morris, Matthew Lorence, Klaus Schafer, Joseph Campos, Mohamadou Sene, Christopher Myers, Dennis Faix, Patrick Blair, Jason Brown, David Metzgar
High-density resequencing microarrays support simultaneous detection and identification of multiple viral and bacterial
pathogens. Because detection and identification using RPM is based upon multiple specimen-specific target pathogen
gene sequences generated in the individual test, the test results enable both a differential diagnostic analysis and
epidemiological tracking of detected pathogen strains and variants from one specimen to the next. The RPM assay
enables detection and identification of pathogen sequences that share as little as 80% sequence similarity to prototype
target gene sequences represented as detector tiles on the array. This capability enables the RPM to detect and identify
previously unknown strains and variants of a detected pathogen, as in sentinel cases associated with an infectious disease
outbreak. We illustrate this capability using assay results from testing influenza A virus vaccines configured with strains
that were first defined years after the design of the RPM microarray. Results are also presented from RPM-Flu testing of
three specimens independently confirmed to the positive for the 2009 Novel H1N1 outbreak strain of influenza virus.
Chiral smectic A electroclinic liquid crystalline materials are prime candidates for electrooptic applications because of their gray scale capability and fast dynamic response. The evolution of this technology greatly depends on the development of chiral smectic A materials with large induced tilt angles, field-independent fast switching times and a broad operating temperature range. We report in this paper the physical properties of a series of liquid crystal materials. Features of this series of materials are broad smectic A phase range and large induced tilt angles. Such large electroclinic coefficients make these materials good candidates of the development of silicon based reflective displays. Comparison of the electrooptic performance of the materials in SmA mesophase will be discussed.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.