Mr. Daniel S. Porreca Profile

Daniel S. Porreca

SPIE Involvement:

Author

Publications (1)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 18 June 2024 Presentation + Paper

Noninvasive in vivo monitoring of plasma volume and hematocrit using the FRD-PVOH device: from cozy to cold

Dan Porreca, Paul Dent, Charles Peterson, J. Chaiken

Proceedings Volume 13011, 1301109 (2024) https://doi.org/10.1117/12.3016876

KEYWORDS: Plasma, Blood, Red blood cells, Tissues, Calibration, Physiology, Capillaries, Skin, In vivo imaging

Read Abstract +

The FRD-PVOH algorithm/medical device enables continuous noninvasive spectroscopic analysis and monitoring of physiology induced changes in the peripheral vasculature in vivo in humans, specifically red blood cell and plasma volume fractions. Previously, FRD-PVOH demonstrated a correlation between mean arterial pressure (MAP) and vascular plasma volume with tilt-table experiments, indicating physiological relevance. Continuous monitoring of plasma volume and hematocrit (Hct) with a total bandwidth of 0-0.3 Hz in volar side fingertip capillary beds, reveals MAP fluctuations superimposed on slower background. These MAP fluctuations isolated from slower vascular volume shifts and the cardiac pulse create a time series associated with vasodilation/vasoconstriction i.e., thermoregulation, an autonomic path to homeostasis. We consistently observe random walk dynamics i.e., the amplitudes of the fluctuations in the time domain are distributed as a Gaussian while Fourier analysis simultaneously confirms the presence of circulatory physiology in the results i.e., breathing effects and the Baroflex response. Lorenz plots indicate linear dynamics control short and long timescale fluctuations across both test subjects. ANOVA analysis of data from a small, on-going, study using a mild external thermoregulation protocol (2 supine subjects, 16 total hours of monitoring for each subject, in 8 sessions of 2 hours each) demonstrates that the number of fluctuations per unit time varies across the two subjects with 95% significance with or without the thermoregulation challenge. Also, the mean number of fluctuations per monitoring session was significantly greater for sessions that included an external thermoregulation challenge compared to those that did not, for both subjects at 95% confidence.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years