Prof. Jerome Mertz Profile

Prof. Jerome Mertz

Professor at Boston Univ

SPIE Involvement:

Conference Program Committee | Author

Publications (41)

Proceedings Article | 13 March 2024 Presentation

In vivo voltage imaging with targeted illumination confocal (TICO) microscopy

Sheng Xiao, William Cunningham, Krishnakanth Kondabolu, Eric Lowet, Maria Moya, Rebecca Mount, Cara Ravasio, Michael Economo, Xue Han, Jerome Mertz

Proceedings Volume PC12828, PC1282804 (2024) https://doi.org/10.1117/12.3000992

KEYWORDS: In vivo imaging, Light sources and illumination, Confocal microscopy, Signal to noise ratio, Optical imaging, Neuroimaging, Crosstalk, Brain, Tissues, Tissue optics

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Proceedings Article | 13 March 2024 Presentation

Fast volumetric imaging in tissue

Jerome Mertz

Proceedings Volume PC12848, PC1284805 (2024) https://doi.org/10.1117/12.3016422

KEYWORDS: Tissues, Biological imaging, Confocal microscopy, Stereoscopy, Speckle imaging, Speckle, Scattering, Neuroimaging, Multiphoton microscopy, Microscopy

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SPIE Journal Paper | 17 November 2023 Open Access

Multiplane HiLo microscopy with speckle illumination and non-local means denoising

Shuqi Zheng, Minoru Koyama, Jerome Mertz

JBO, Vol. 28, Issue 11, 116502, (November 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.11.116502

KEYWORDS: Speckle, Light sources and illumination, Denoising, Microscopy, Fluorescence imaging, Cameras, Tunable filters, Image processing, Neurons, Signal to noise ratio

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SPIE Journal Paper | 27 October 2023 Open Access

Resolution enhancement with deblurring by pixel reassignment

Bingying Zhao, Jerome Mertz

AP, Vol. 5, Issue 06, 066004, (October 2023) https://doi.org/10.1117/12.10.1117/1.AP.5.6.066004

KEYWORDS: Point spread functions, Image enhancement, Deblurring, Image resolution, Microscopes, Resolution enhancement technologies, Confocal microscopy, Tunable filters, Deconvolution, Image deconvolution

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Proceedings Article | 28 April 2022 Presentation

Multi-plane 3D optical voltage imaging using high-speed multi-Z confocal microscopy

Timothy Weber, Maria Moya, Michael Economo, Jerome Mertz

Proceedings Volume PC11946, PC1194606 (2022) https://doi.org/10.1117/12.2607867

KEYWORDS: Optical imaging, Confocal microscopy, Stereoscopy, 3D image processing, In vivo imaging, Signal to noise ratio, Scattering, Microscopy, Microscopes, In vitro testing

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Proceedings Article | 28 April 2022 Presentation

Large-scale optical voltage imaging in behaving animals

Sheng Xiao, Eric Lowet, Howard Gritton, Pierre Fabris, Jerome Mertz, Xue Han

Proceedings Volume PC11946, PC1194608 (2022) https://doi.org/10.1117/12.2609095

KEYWORDS: Optical imaging, Neurons, Microscopy, Brain, Neuroimaging, Imaging systems, System integration, Luminescence, Digital micromirror devices, Contamination

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Proceedings Article | 1 April 2022 Presentation

Flatfield ultrafast imaging with single-shot non-synchronous array photography

Matthew Sheinman, Shyamsunder Erramilli, Lawrence Ziegler, Mi Hong, Jerome Mertz

Proceedings Volume PC11986, PC1198608 (2022) https://doi.org/10.1117/12.2610098

KEYWORDS: Computer programming, Microlens array, Ultrafast imaging, Temporal resolution, Sensors, Plasma, Photography, Laser beam diagnostics, Imaging arrays, Diffractive optical elements

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Proceedings Article | 7 March 2022 Presentation

Multiphoton microscopy – deeper, faster

Jerome Mertz

Proceedings Volume PC11965, PC1196508 (2022) https://doi.org/10.1117/12.2614033

KEYWORDS: Multiphoton microscopy, Tissues

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Proceedings Article | 3 March 2022 Presentation

Correction for background scattering dynamics in quantitative laser speckle contrast imaging

Shuqi Zheng, Lisa Kretsge, Alberto Cruz-Martín, Jerome Mertz

Proceedings Volume PC11974, PC119740A (2022) https://doi.org/10.1117/12.2608356

KEYWORDS: Scattering, Speckle, Laser speckle contrast imaging, Laser scattering, Light scattering, Tissues, Tissue optics, In vivo imaging, Error analysis, Dynamic light scattering

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Proceedings Article | 2 March 2022 Presentation

A novel strategy for high-speed high-throughput laser scanning

Sheng Xiao, Jerome Mertz

Proceedings Volume PC11971, PC1197102 (2022) https://doi.org/10.1117/12.2609001

KEYWORDS: Microscopes, Laser scanners, Mirrors, Ultrafast phenomena, Ultrafast imaging, Scanners, Raster graphics, Polygon scanners, Microscopy

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Proceedings Article | 5 March 2021 Presentation

High-resolution corneal and lens imaging with retroillumination microscopy

Timothy Weber, Jerome Mertz

Proceedings Volume 11623, 116230S (2021) https://doi.org/10.1117/12.2578539

KEYWORDS: Microscopy, Nerve, Microscopes, In vivo imaging, Image segmentation, Image resolution, Crystals, Cornea, 3D image processing

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Proceedings Article | 5 March 2021 Presentation

Single-shot high-contrast multiplane imaging with a z-splitter prism

Sheng Xiao, Howard Gritton, Hua-an Tseng, Dana Zemel, Xue Han, Jerome Mertz

Proceedings Volume 11649, 1164906 (2021) https://doi.org/10.1117/12.2581250

KEYWORDS: Prisms, Cameras, Deconvolution, Microscopy, 3D image processing, Signal to noise ratio, Organisms, Neuroimaging, Microscopes

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Proceedings Article | 13 March 2019 Presentation

Ocular fundus imaging with transmitted light (Conference Presentation)

Timothy Weber, Jerome Mertz

Proceedings Volume 10858, 1085816 (2019) https://doi.org/10.1117/12.2507989

KEYWORDS: Spectroscopy, Absorption, Near infrared, Nerve, Blood vessels, Visibility, Imaging spectroscopy, Chromophores, Eye models, Bone

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Proceedings Article | 4 March 2019 Presentation

Video-rate volumetric neuronal imaging with multi-z confocal microscopy (Conference Presentation)

Amaury Badon, Seth Bensussen, Mehraj Awal, Howard Gritton, Christopher Gabel, Xue Han, Jerome Mertz

Proceedings Volume 10889, 108890H (2019) https://doi.org/10.1117/12.2506646

KEYWORDS: Confocal microscopy, Neurons, Microscopes, Objectives, Microscopy, Video microscopy, Video, In vivo imaging, Image resolution, Multilayers

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Proceedings Article | 4 March 2019 Presentation

Pseudo-volumetric fluorescence endomicroscopy with a fiber bundle (Conference Presentation)

Jean-Marc Tsang, Jason Ritt, Jerome Mertz

Proceedings Volume 10854, 1085411 (2019) https://doi.org/10.1117/12.2510407

KEYWORDS: Endomicroscopy, Luminescence, Stereoscopy, Brain, Confocal microscopy, Image resolution, In vivo imaging, Neuroimaging, Tissues, 3D image processing

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Proceedings Article | 21 February 2017 Presentation + Paper

Extended depth-of-field microscopy with a high-speed deformable mirror

William Shain, Nicholas Vickers, Bennett Goldberg, Thomas Bifano, Jerome Mertz

Proceedings Volume 10073, 100730E (2017) https://doi.org/10.1117/12.2271502

KEYWORDS: Microscopes, Microscopy, Optical transfer functions, Cameras, Luminescence, Deformable mirrors, Deconvolution, Brain, Tissues, Air contamination

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SPIE Journal Paper | 22 September 2016 Open Access

Widefield fluorescence microscopy with sensor-based conjugate adaptive optics using oblique back illumination

Jiang Li, Thomas Bifano, Jerome Mertz

JBO, Vol. 21, Issue 12, 121504, (September 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.12.121504

KEYWORDS: Adaptive optics, Luminescence, Wavefront sensors, Microscopy, Sensors, Cameras, Wavefronts, Microscopes, Objectives, Signal to noise ratio

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Proceedings Article | 27 April 2016 Presentation

Adaptive optics without guide stars (Conference Presentation)

Jerome Mertz, Jiang Li, Devin Beaulieu, Hari Paudel, Roman Barankov, Thomas Bifano

Proceedings Volume 9717, 97170F (2016) https://doi.org/10.1117/12.2218574

KEYWORDS: Adaptive optics, Stars, Microscopy, Sensors, Image sensors, Aberration correction, Wavefront sensors, Optical sensors, Cameras, Statistical analysis

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SPIE Journal Paper | 3 June 2013 Open Access

Video-rate imaging of microcirculation with single-exposure oblique back-illumination microscopy

Tim Ford, Jerome Mertz

JBO, Vol. 18, Issue 06, 066007, (June 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.6.066007

KEYWORDS: Prisms, Tissues, Capillaries, Absorption, Blood circulation, Distortion, Video, Cameras, Image registration, Microscopy

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SPIE Journal Paper | 5 April 2013 Open Access

Special Section Guest Editorial: Multiphoton Microscopy: Technical Innovations, Biological Applications, and Clinical Diagnostics

Chen-Yuan Dong, Peter So, Jerome Mertz, Karsten Koenig, Chris Xu, Paul Campagnola

JBO, Vol. 18, Issue 03, 031101, (April 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.3.031101

KEYWORDS: Multiphoton microscopy, Diagnostics, Optical microscopy, Harmonic generation, Tissues, Microscopy, Molecules, Absorption, Range imaging, Tissue optics

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Proceedings Article | 5 March 2013 Paper

Focusing polychromatic light through scattering media

Hari Paudel, Chris Stockbridge, Jerome Mertz, Thomas Bifano

Proceedings Volume 8617, 86170D (2013) https://doi.org/10.1117/12.2005350

KEYWORDS: Speckle, Light scattering, Scattering, Scattering media, Spatial light modulators, Cameras, Speckle pattern, Optimization (mathematics), Light sources, Microelectromechanical systems

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SPIE Journal Paper | 13 March 2012 Open Access

Fast optically sectioned fluorescence HiLo endomicroscopy

Timothy Ford, Daryl Lim, Jerome Mertz

JBO, Vol. 17, Issue 02, 021105, (March 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.2.021105

KEYWORDS: Cameras, Luminescence, Endomicroscopy, Video, Image processing, Image resolution, Optical filters, Biomedical optics, Linear filtering, Spatial frequencies

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SPIE Journal Paper | 1 January 2010 Open Access

Scanning light-sheet microscopy in the whole mouse brain with HiLo background rejection

Jerome Mertz, Jinhyun Kim

JBO, Vol. 15, Issue 01, 016027, (January 2010) https://doi.org/10.1117/12.10.1117/1.3324890

KEYWORDS: Microscopy, Brain, Neuroimaging, Scattering, Light scattering, Image resolution, Luminescence, Microscopes, Mirrors, Image processing

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Proceedings Article | 13 July 2009 Paper

Intravital fiber-optic fluorescence imaging for monitoring ovarian carcinoma progression and treatment response

Bryan Spring, Jonathan Celli, Conor Evans, Wei Zhong, Imran Rizvi, Zhiming Mai, Jerome Mertz, Seok Yun, Tayyaba Hasan

Proceedings Volume 7380, 73800L (2009) https://doi.org/10.1117/12.828206

KEYWORDS: Tumors, Luminescence, Photodynamic therapy, Fiber optics, Ovarian cancer, In vivo imaging, Image processing, 3D modeling, Tumor growth modeling, Picosecond phenomena

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SPIE Journal Paper | 1 May 2009 Open Access

Optically sectioned fluorescence endomicroscopy with hybrid-illumination imaging through a flexible fiber bundle

Silvia Santos, Kengyeh Chu, Daryl Lim, Nenad Bozinovic, Timothy Ford, Claire Hourtoule, Aaron Bartoo, Satish Singh, Jerome Mertz

JBO, Vol. 14, Issue 03, 030502, (May 2009) https://doi.org/10.1117/12.10.1117/1.3130266

KEYWORDS: Image fusion, Microscopy, Luminescence, Endomicroscopy, Linear filtering, Image resolution, Image processing, Spatial frequencies, Video, Modulation

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Proceedings Article | 24 February 2009 Paper

Two-photon fluorescence microscopy with differential aberration imaging

Kengyeh Chu, Aymeric Leray, Thomas Bifano, Jerome Mertz

Proceedings Volume 7209, 720903 (2009) https://doi.org/10.1117/12.812230

KEYWORDS: Luminescence, Scattering, Mirrors, Laser scattering, Optical transfer functions, Signal attenuation, Tissues, Diffraction, Image filtering, Two photon excitation microscopy

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Proceedings Article | 12 February 2007 Paper

Two-photon fluorescence background rejection by differential aberration imaging

Aymeric Leray, Kyle Lillis, Jerome Mertz

Proceedings Volume 6442, 64421G (2007) https://doi.org/10.1117/12.701252

KEYWORDS: Luminescence, Microscopes, Deformable mirrors, Laser scattering, Tissues, Objectives, Calcium, Point spread functions, Microscopy, Laser tissue interaction

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Proceedings Article | 9 February 2007 Paper

Two photon fluorescence background rejection by differential aberration imaging

Aymeric Leray, Kyle Lillis, Jerome Mertz

Proceedings Volume 6467, 646704 (2007) https://doi.org/10.1117/12.707443

KEYWORDS: Luminescence, Microscopes, Deformable mirrors, Laser scattering, Tissues, Objectives, Calcium, Point spread functions, Microscopy, Laser tissue interaction

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Proceedings Article | 23 February 2006 Paper

Quasi-confocal fluorescence sectioning with dynamic speckle illumination

Cathie Ventalon, Jerome Mertz

Proceedings Volume 6090, 60900M (2006) https://doi.org/10.1117/12.646889

KEYWORDS: Speckle, Luminescence, Speckle pattern, Confocal microscopy, Tissues, Microscopes, Tissue optics, Objectives, Microscopy, Scattering media

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Proceedings Article | 15 October 2004 Paper

Nanoscale multipolar chromophores for optical limiting in the visible-NIR range based on multiphoton absorption

Olivier Mongin, Marina Charlot, Claudine Katan, Laurent Porres, Manuel Parent, Thomas Pons, Jerome Mertz, Mireille Blanchard-Desce

Proceedings Volume 5516, (2004) https://doi.org/10.1117/12.559937

KEYWORDS: Chromophores, Absorption, Near infrared, Optical limiting, Visible radiation, Photovoltaics, Luminescence, Transparency, Multiphoton processes, Femtosecond phenomena

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Proceedings Article | 9 October 2003 Paper

Photo-induced flip-flop of membrane markers monitored by SHG microscopy

Thomas Pons, Jerome Mertz

Proceedings Volume 5139, (2003) https://doi.org/10.1117/12.500076

KEYWORDS: Second-harmonic generation, Molecules, Microscopy, Luminescence, Absorption, Image segmentation, Diffusion, Harmonic generation, Biomedical optics, Nonlinear optics

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Proceedings Article | 10 July 2003 Paper

Photo-induced flip-flop of amphiphilic membrane markers

Thomas Pons, Jerome Mertz

Proceedings Volume 4963, (2003) https://doi.org/10.1117/12.478022

KEYWORDS: Second-harmonic generation, Molecules, Luminescence, Absorption, Microscopy, Image segmentation, Diffusion, Harmonic generation, Femtosecond phenomena, Polarization

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Proceedings Article | 10 July 2003 Paper

New implementation of second harmonic generation microscopy for three-dimensional resolution

Changhuei Yang, Jerome Mertz

Proceedings Volume 4963, (2003) https://doi.org/10.1117/12.478032

KEYWORDS: Second-harmonic generation, Crystals, Light scattering, Microscopy, Confocal microscopy, Signal detection, Microscopes, Harmonic generation, Scattering, Latex

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SPIE Journal Paper | 1 July 2003 Open Access

Mechanisms of membrane potential sensing with second-harmonic generation microscopy

Thomas Pons, Laurent Moreaux, Olivier Mongin, Mireille Blanchard-Desce, Jerome Mertz

JBO, Vol. 8, Issue 03, (July 2003) https://doi.org/10.1117/12.10.1117/1.1581871

KEYWORDS: Second-harmonic generation, Electro optics, Microscopy, Molecules, Line scan image sensors, Switching, Polarization, Sensors, Electrodes, Hyper Rayleigh scattering

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Proceedings Article | 14 February 2003 Paper

Molecular Engineering of Nanoscale Quadrupolar Chromophores for Two-Photon Absorption

Laurent Porres, Olivier Mongin, Mireille Blanchard-Desce, Lionel Ventelon, Marguerite Barzoukas, Laurent Moreaux, Thomas Pons, Jerome Mertz

Proceedings Volume 4797, (2003) https://doi.org/10.1117/12.453476

KEYWORDS: Absorption, Luminescence, Chromophores, Transparency, Quantum efficiency, Molecules, Visible radiation, Imaging systems, Sapphire lasers, Optical limiting

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Proceedings Article | 1 November 2002 Paper

Molecular probes for two-photon excited fluorescence and second harmonic generation imaging of biological membranes

Laurent Porres, Olivier Mongin, Bharath Bhatthula, Mireille Blanchard-Desce, Lionel Ventelon, Laurent Moreaux, T. Pons, Jerome Mertz

Proceedings Volume 4812, (2002) https://doi.org/10.1117/12.451378

KEYWORDS: Second-harmonic generation, Luminescence, Microscopy, Nonlinear optics, Chromophores, Imaging systems, Quantum efficiency, Harmonic generation, Absorption, Molecules

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Proceedings Article | 17 June 2002 Paper

Perturbative theory of the electro-optic response of second-harmonic generation membrane potential sensors

Jerome Mertz, Laurent Moreaux, T. Pons

Proceedings Volume 4620, (2002) https://doi.org/10.1117/12.470691

KEYWORDS: Chromophores, Second-harmonic generation, Molecules, Electro optics, Sensors, Microscopy, Nonlinear optics, Absorption, Modulation, Luminescence

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Proceedings Article | 7 December 2001 Paper

Molecular probes for nonlinear optical imaging of biological membranes

Mireille Blanchard-Desce, Lionel Ventelon, Sandrine Charier, Laurent Moreaux, Jerome Mertz

Proceedings Volume 4461, (2001) https://doi.org/10.1117/12.449848

KEYWORDS: Second-harmonic generation, Luminescence, Microscopy, Molecules, Chromophores, Absorption, Quantum efficiency, Nonlinear optics, Anisotropy, Optical imaging

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Proceedings Article | 2 November 2001 Paper

Strategies for improving depth-penetration of two-photon imaging in vivo

Martin Oheim, Emmanuel Beaurepaire, Jerome Mertz, Serge Charpak

Proceedings Volume 4431, (2001) https://doi.org/10.1117/12.447410

KEYWORDS: Luminescence, Objectives, Brain, Scattering, Tissues, In vivo imaging, Microscopes, Sensors, Laser scattering, Tissue optics

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Proceedings Article | 24 April 2001 Paper

Multiharmonic light microscopy: theory and applications in membrane imaging

Jerome Mertz, Laurent Moreaux

Proceedings Volume 4262, (2001) https://doi.org/10.1117/12.424561

KEYWORDS: Molecules, Microscopy, Multiphoton microscopy, Scattering, Absorption, Luminescence, Light scattering, Second-harmonic generation, Laser scattering, Microscopes

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Proceedings Article | 13 November 1996 Paper

Multiphoton fluorescence excitation: new spectral windows for biological imaging

Chris Xu, Jerome Mertz, J. Shear, Watt Webb

Proceedings Volume 2819, (1996) https://doi.org/10.1117/12.258073

KEYWORDS: Luminescence, Microscopy, Multiphoton fluorescence microscopy, Photons, Multiphoton microscopy, Ultraviolet radiation, Confocal microscopy, Absorption, Biological research, Proteins

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Showing 5 of 41 publications

Conference Committee Involvement (26)

Quantitative Phase Imaging XI

25 January 2025 | San Francisco, California, United States

Quantitative Phase Imaging X

27 January 2024 | San Francisco, California, United States

Advances in Microscopic Imaging

28 June 2023 | Munich, Germany

Quantitative Phase Imaging IX

28 January 2023 | San Francisco, California, United States

Quantitative Phase Imaging VIII

22 January 2022 | San Francisco, California, United States

Advances in Microscopic Imaging

20 June 2021 | Online Only, Germany

Quantitative Phase Imaging VII

6 March 2021 | Online Only, California, United States

Quantitative Phase Imaging VI

1 February 2020 | San Francisco, California, United States

Advances in Microscopic Imaging

26 June 2019 | Munich, Germany

Quantitative Phase Imaging V

2 February 2019 | San Francisco, California, United States

Quantitative Phase Imaging IV

28 January 2018 | San Francisco, California, United States

Advances in Microscopic Imaging

25 June 2017 | Munich, Germany

Quantitative Phase Imaging III

29 January 2017 | San Francisco, California, United States

Quantitative Phase Imaging II

14 February 2016 | San Francisco, California, United States

Advanced Microscopy Techniques IV

24 June 2015 | Munich, Germany

Quantitative Phase Imaging

7 February 2015 | San Francisco, California, United States

Advanced Microscopy Techniques III

12 May 2013 | Munich, Germany

Advanced Microscopy Techniques II

22 May 2011 | Munich, Germany

Multiphoton Microscopy in the Biomedical Sciences VIII

20 January 2008 | San Jose, California, United States

Confocal, Multiphoton, and Nonlinear Microscopic Imaging

17 June 2007 | Munich, Germany

Multiphoton Microscopy in the Biomedical Sciences VII

21 January 2007 | San Jose, California, United States

Multiphoton Microscopy in the Biomedical Sciences VI

22 January 2006 | San Jose, California, United States

Multiphoton Microscopy in the Biomedical Sciences V

23 January 2005 | San Jose, CA, United States

Multiphoton Microscopy in the Biomedical Sciences IV

25 January 2004 | San Jose, CA, United States

Confocal, Multiphoton, and Nonlinear Microscopic Imaging

22 June 2003 | Munich, Germany

Multiphoton Microscopy in the Biomedical Sciences III

26 January 2003 | San Jose, CA, United States

Showing 5 of 26 Conference Committees

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