We report the advancement of magnetomotive micro-optical coherence tomography (µOCT) technology for mapping the cystic fibrosis (CF) mucus viscoelastic properties in situ. We conducted pilot experiments in ex-vivo CF ferret trachea and wild-type swine trachea with a new magnetomotive system design. The system utilizes an electromagnet to drive magnetic nanoparticles with constant and uniform magnetomotive force in the field of view of µOCT. Preliminary results showed that the new system enhances individual magnetic micro-particle tracking and enables the measurement of the viscoelastic properties in different compartments of the mucus.
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