We have developed an optical imaging system that allows monitoring arthritis in systemic lupus erythematosus (SLE) patients in multiple finger joints simultaneously. This system addresses the need for a low-cost accurate way to quickly assess SLE in a patient friendly manner. system comprises multiple flexible optical bands for each finger. Each band includes eight sets of three light-emitting-diodes (LEDs) (wavelength λ = 880 nm, 660 nm, and 530 nm) and a photodiode and can be wrapped around a proximal inter-phalangeal (PIP) joint allowing for the measurement of reflected and transmitted light from the LEDs by the photodetector. 24 LEDs and 8 detectors combine for a total of 192 measurements per finger per frame, which is acquired at a frame rate of 1 frame per second. We tested the performance of the system in a clinical pilot study comparing the results to an existing single-band system that makes measurements on one PIP joint at a time. During data acquisition, a partial venous inclusion is induced using a blood pressure cuff inflated to the subject’s diastolic blood pressure. Initial results show statistically significant differences between SLE patient and healthy volunteers, agreeing with our previous findings single-band technology.
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