Circulating tumor cell clusters (CTCCs) are extremely rare events (<4 events per 7.5 mL of blood) found in the bloodstream of metastatic cancer patients. Despite their scarcity, they represent an increased risk for metastasis. Detection and isolation of CTCCs remain a priority for oncologists to improve cancer patients' diagnosis, stratification, and treatment. This study aims to demonstrate that confocal backscatter and fluorescence flow cytometry (BSFC) with deep learning-based signal analysis can enable sensitive detection of CTCCs in whole blood in vitro and in vivo without using exogenous labeling.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.