Ionizing radiation acoustic imaging (iRAI) provides the potential to map the radiation dose during radiotherapy in real time. Described here is our recent development of an iRAI volumetric imaging system in mapping the three-dimensional (3D) radiation dose deposition of a complex clinical radiotherapy treatment plan. Temporal 3D dose accumulation of a treatment plan was first imaged in a phantom. Then, semi-quantitative iRAI measurements were verified with rabbit liver model in vivo. Finally, for the first time, real-time visualization of radiation dose delivered deep in a patient with liver metastases was successfully performed. These studies demonstrate the potential of iRAI to map the dose distribution in deep body during radiotherapy, potentially leading to personalized radiotherapy with optimal efficacy and safety.
KEYWORDS: Radiotherapy, Associative arrays, Real time imaging, Acoustics, Ionizing radiation, In vivo imaging, 3D modeling, Transducers, Tissues, Liver
Ironizing radiation acoustic imaging (iRAI) is a novel imaging concept with the potential to map the radiation dose delivery in real time during external beam radiation therapy. In this study, iRAI volumetric dose mapping was achieved with 2D matrix transducer array using a C-shape 3D conformal treatment plan with clinically relevant setting and a moving beam plan in both phantoms and rabbit model in vivo. With the unique ability to map the volumetric dose delivery in real time, iRAI 3D dose mapping can be developed into a new tool for quantifying the accuracy of dose delivery of radiation therapy.
As a newly invented technology, ionizing radiation acoustic imaging (iRAI) provides a potential solution for in vivo dosimetry and real-time online monitoring of radiation beam position during external beam radiotherapy, including both conventional and FLASH radiotherapy. In this study, the dose resolution as low as 1% from a single pulse was achieved, demonstrating a clinically acceptable sensitivity of iRAI in mapping the dose deposition. The relative displacement of the radiation beam with respect to the target tissue can be visualized in real time by our clinically ready iRAI and ultrasound (US) dual-modality imaging system.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.