Dr. Paul Lemaillet Profile

Dr. Paul Lemaillet

Staff Fellow

Area of Expertise:

Optics , Ellipsometry , Optical Phantoms , Polarization , Scatterometry , Spectroscopy

Profile Summary

Extensive experience in optics over 10 years.

Participated and led multiple optical research projects with various applications in metrology, biotechnology and medicine.

Specialties:
Optical systems development, setup, alignment, automation and calibration.
Spectroscopy, Hyper-Spectral Imaging, Polarimetry, Non-linear Optics.

Publications (20)

Proceedings Article | 7 March 2022 Presentation

Presentation

Head-mounted display luminance characterization for medical virtual reality

Eshan Dahal, Noah Eby, Paul Lemaillet, Aldo Badano

Proceedings Volume PC11931, PC1193102 (2022) https://doi.org/10.1117/12.2613053

KEYWORDS: Virtual reality, Head-mounted displays, Photodiodes, Integrating spheres, Stray light, Photometry, Optical filters, Electronic filtering, Diagnostics, Contamination

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SPIE Journal Paper | 18 November 2021 Open Access

Open Access

Polydimethylsiloxane tissue-mimicking phantoms with tunable optical properties

Aaron Goldfain, Paul Lemaillet, David Allen, Kimberly Briggman, Jeeseong Hwang

JBO, Vol. 27, Issue 07, 074706, (November 2021) https://doi.org/10.1117/12.10.1117/1.JBO.27.7.074706

KEYWORDS: Scattering, Absorption, Tissues, Light scattering, Particles, Optical properties, Tissue optics, Integrating spheres, Rayleigh scattering, Picosecond phenomena

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Significance: The polymer, polydimethylsiloxane (PDMS), has been increasingly used to make tissue simulating phantoms due to its excellent processability, durability, flexibility, and limited tunability of optical, mechanical, and thermal properties. We report on a robust technique to fabricate PDMS-based tissue-mimicking phantoms where the broad range of scattering and absorption properties are independently adjustable in the visible- to near-infrared wavelength range from 500 to 850 nm. We also report on an analysis method to concisely quantify the phantoms’ broadband characteristics with four parameters. Aim: We report on techniques to manufacture and characterize solid tissue-mimicking phantoms of PDMS polymers. Tunability of the absorption (μa ( λ ) ) and reduced scattering coefficient spectra (μs′(λ)) in the wavelength range of 500 to 850 nm is demonstrated by adjusting the concentrations of light absorbing carbon black powder (CBP) and light scattering titanium dioxide powder (TDP) added into the PDMS base material. Approach: The μa ( λ ) and μs′(λ) of the phantoms were obtained through measurements with a broadband integrating sphere system and by applying an inverse adding doubling algorithm. Analyses of μa ( λ ) and μs′(λ) of the phantoms, by fitting them to linear and power law functions, respectively, demonstrate that independent control of μa ( λ ) and μs′(λ) is possible by systematically varying the concentrations of CBP and TDP. Results: Our technique quantifies the phantoms with four simple fitting parameters enabling a concise tabulation of their broadband optical properties as well as comparisons to the optical properties of biological tissues. We demonstrate that, to a limited extent, the scattering properties of our phantoms mimic those of human tissues of various types. A possible way to overcome this limitation is demonstrated with phantoms that incorporate polystyrene microbead scatterers. Conclusions: Our manufacturing and analysis techniques may further promote the application of PDMS-based tissue-mimicking phantoms and may enable robust quality control and quality checks of the phantoms.

SPIE Journal Paper | 7 October 2021

Colorimetrical uncertainty estimation for the performance assessment of whole slide imaging scanners

Paul Lemaillet, Kazuyo Takeda, Andrew Lamont, Anant Agrawal

JMI, Vol. 8, Issue 05, 057501, (October 2021) https://doi.org/10.1117/12.10.1117/1.JMI.8.5.057501

KEYWORDS: Scanners, Tissues, Image registration, Transmittance, Microscopy, Imaging systems, Color difference, Calibration, Color reproduction, Microscopes

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Proceedings Article | 15 February 2021 Presentation + Paper

Presentation + Paper

Colorimetrical evaluation of color normalization methods for H&E-stained images

Jocelyn Liu, Samuel Lam, Paul Lemaillet, Wei-Chung Cheng

Proceedings Volume 11603, 116030U (2021) https://doi.org/10.1117/12.2582281

KEYWORDS: Tissues, Visualization, Transmittance, Scanners, Principal component analysis, Pathology, Image processing, Diagnostics

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Proceedings Article | 16 March 2017 Paper

Paper

Broadband spectral measurements of diffuse optical properties by an integrating sphere instrument at the National Institute of Standards and Technology

Paul Lemaillet, Jeeseong Hwang, Heidrun Wabnitz, Dirk Grosenick, Lin Yang, David Allen

Proceedings Volume 10056, 1005604 (2017) https://doi.org/10.1117/12.2263338

KEYWORDS: Indium oxide, Scattering, Optical properties, Integrating spheres, Reflectivity, Transmittance, Standards development, Optical testing, Optical spheres, Solids

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Proceedings Article | 15 March 2017 Paper

Paper

Label-free hyperspectral dark-field microscopy for quantitative scatter imaging

Philip Cheney, David McClatchy, Stephen Kanick, Paul Lemaillet, David Allen, Daniel Samarov, Brian Pogue, Jeeseong Hwang

Proceedings Volume 10056, 1005602 (2017) https://doi.org/10.1117/12.2263336

KEYWORDS: Scattering, Monte Carlo methods, Reflectivity, Optical spheres, Microscopy, Tissues, Microscopes, Distributed interactive simulations, Objectives, Transmittance

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Proceedings Article | 15 March 2017 Paper

Paper

Polydimethylsiloxane tissue-mimicking phantoms for quantitative optical medical imaging standards

Jeeseong Hwang, Hyun-Jin Kim, Paul Lemaillet, Heidrun Wabnitz, Dirk Grosenick, Lin Yang, Thomas Gladytz, David McClatchy, David Allen, Kimberly Briggman, Brian Pogue

Proceedings Volume 10056, 1005603 (2017) https://doi.org/10.1117/12.2263379

KEYWORDS: Scattering, Particles, Confocal microscopy, Tissue optics, Light scattering, Integrating spheres, Tissues, Reflectivity, Standards development, Backscatter

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Proceedings Article | 11 October 2016 Paper

Paper

Goniometric and hemispherical reflectance and transmittance measurements of fused silica diffusers

Paul Lemaillet, Heather Patrick, Thomas Germer, Leonard Hanssen, B. Carol Johnson, Georgi Georgiev

Proceedings Volume 9961, 996109 (2016) https://doi.org/10.1117/12.2237975

KEYWORDS: IRIS Consortium, Diffusers, Reflectivity, Transmittance, Silica, Scattering, Bidirectional reflectance transmission function, Optical spheres, Sensors, Integrating spheres

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Proceedings Article | 24 March 2016 Presentation + Paper

Presentation + Paper

National Institute of Standards and Technology measurement service of the optical properties of biomedical phantoms: current status

Paul Lemaillet, Catherine Cooksey, Zachary Levine, Adam Pintar, Jeeseong Hwang, David Allen

Proceedings Volume 9700, 970002 (2016) https://doi.org/10.1117/12.2214569

KEYWORDS: Bidirectional reflectance transmission function, Optical properties, Indium oxide, Biomedical optics, Polarization, Monte Carlo methods, Standards development, Scattering, Transmittance, Solids

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Proceedings Article | 18 March 2016 Presentation + Paper

Presentation + Paper

Optical characterization of tissue mimicking phantoms by a vertical double integrating sphere system

Yilin Han, Qiumin Jia, Shuwei Shen, Guangli Liu, Yuwei Guo, Ximing Zhou, Jiaru Chu, Gang Zhao, Erbao Dong, David Allen, Paul Lemaillet, Ronald Xu

Proceedings Volume 9700, 97000A (2016) https://doi.org/10.1117/12.2212287

KEYWORDS: Tissue optics, Integrating spheres, System integration, Absorption, Scattering, 3D printing, Tissues, Integrated optics, Optical properties, Biomedical optics, Titanium dioxide, Optical testing, Liquids, Solids

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SPIE Journal Paper | 27 October 2015 Open Access

Open Access

Double-integrating-sphere system at the National Institute of Standards and Technology in support of measurement standards for the determination of optical properties of tissue-mimicking phantoms

Paul Lemaillet, Jean-Pierre Bouchard, Jeeseong Hwang, David Allen

JBO, Vol. 20, Issue 12, 121310, (October 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.12.121310

KEYWORDS: Optical properties, Reflectivity, Indium oxide, Optical spheres, Scattering, Transmittance, Standards development, Absorption, Tissue optics, Biomedical optics

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Proceedings Article | 6 March 2015 Paper

Paper

Measurement of the optical properties of solid biomedical phantoms at the National Institute of Standards and Technology

Paul Lemaillet, David Allen, Jeeseong Hwang

Proceedings Volume 9325, 932504 (2015) https://doi.org/10.1117/12.2085110

KEYWORDS: Indium oxide, Optical properties, Solids, Optical testing, Reflectivity, Biomedical optics, Optical spheres, Transmittance, Standards development, Scattering

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Proceedings Article | 10 April 2013 Paper

Paper

Intercomparison between optical and x-ray scatterometry measurements of FinFET structures

P. Lemaillet, T. Germer, R. Joseph Kline, Daniel Sunday, Chengqing Wang, Wen-li Wu

Proceedings Volume 8681, 86810Q (2013) https://doi.org/10.1117/12.2011144

KEYWORDS: X-rays, X-ray optics, Scatterometry, Metrology, Silica, Scattering, Interfaces, Scatter measurement, Silicon

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SPIE Journal Paper | 9 July 2012 Open Access

Open Access

Out-of-plane Stokes imaging polarimeter for early skin cancer diagnosis

Pejhman Ghassemi, Paul Lemaillet, Jessica Ramella-Roman, Jeffrey Shupp, Suraj Venna, Marc Boisvert, Katherine Flanagan, Marion Jordan, Thomas Germer

JBO, Vol. 17, Issue 7, 076014, (July 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.7.076014

KEYWORDS: Polarization, Scattering, Skin, Polarimetry, Light scattering, Melanoma, Skin cancer, Calibration, Imaging systems, Polarizers

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Proceedings Article | 18 February 2011 Paper

Paper

Hemispherical Stokes polarimeter for early cancer diagnosis

Paul Lemaillet, Jessica Ramella-Roman

Proceedings Volume 7883, 788304 (2011) https://doi.org/10.1117/12.873608

KEYWORDS: Polarization, Polarimetry, Scattering, Skin, Polarizers, Liquid crystals, Calibration, Imaging systems, Wave plates, Optical properties

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SPIE Journal Paper | 1 September 2010 Open Access

Open Access

Absolute blood velocity measured with a modified fundus camera

Donald Duncan, Paul Lemaillet, Mohamed Ibrahim, Quan Dong Nguyen, Matthias Hiller, Jessica Ramella-Roman

JBO, Vol. 15, Issue 05, 056014, (September 2010) https://doi.org/10.1117/12.10.1117/1.3494565

KEYWORDS: Blood, Cameras, Velocity measurements, Error analysis, Signal to noise ratio, Radon transform, In vitro testing, Eye, Image processing, Blood circulation

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Proceedings Article | 3 March 2010 Paper

Paper

Retinal oximetry with a multiaperture camera

Paul Lemaillet, Art Lompado, Mohamed Ibrahim, Quan Dong Nguyen, Jessica Ramella-Roman

Proceedings Volume 7550, 755021 (2010) https://doi.org/10.1117/12.841980

KEYWORDS: Reflectivity, Retina, Oxygen, Calibration, Eye, Cameras, Absorption, Optical filters, Charge-coupled devices, Oximetry

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SPIE Journal Paper | 1 November 2009 Open Access

Open Access

Dynamic eye phantom for retinal oximetry measurements

Paul Lemaillet, Jessica Ramella-Roman

JBO, Vol. 14, Issue 06, 064008, (November 2009) https://doi.org/10.1117/12.10.1117/1.3258669

KEYWORDS: Eye, Oxygen, Scattering, Eye models, Optical properties, Reflectivity, Blood, Oximetry, Retina, Absorption

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Proceedings Article | 28 February 2009 Paper

Paper

Improvement of a snapshot spectroscopic retinal multi-aperture imaging camera

Paul Lemaillet, Art Lompado, Jessica Ramella-Roman

Proceedings Volume 7262, 72622G (2009) https://doi.org/10.1117/12.811565

KEYWORDS: Cameras, Lenses, Oxygen, Eye, Charge-coupled devices, Spectroscopy, Imaging spectroscopy, Retina, Optical filters, Retinal scanning

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Proceedings Article | 13 September 2007 Paper

Paper

Development of a pulse laser source-operated achromatic dual-rotating-retarder polarimeter designed for hyper-Rayleigh scattering measurements

Paul Lemaillet, Sylvain Rivet, Fabrice Pellen, Bernard Le Jeune, Jack Cariou

Proceedings Volume 6682, 66820T (2007) https://doi.org/10.1117/12.731315

KEYWORDS: Quartz, Calibration, Condition numbers, Wave plates, Polarimetry, Polarization, Scattering, Second-harmonic generation, Polarizers, Hyper Rayleigh scattering

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Showing 5 of 20 publications

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