Prof. Roger J. Zemp Profile

Prof. Roger J. Zemp

Professor at Univ of Alberta

SPIE Involvement:

Conference Program Committee | Author | Editor

Publications (125)

Proceedings Article | 13 March 2024 Presentation

Photoacoustic remote sensing microscopy and meta-LASE microscopy for visualizing virtual histology, circulating tumor cells, and tissue energetics

Pradyumna Kedarisetti, Nathaniel J. Haven, Matthew Martell, Frank Wuest, Roger Zemp

Proceedings Volume PC12854, PC128540I (2024) https://doi.org/10.1117/12.3002145

KEYWORDS: Biological imaging, White blood cells, Tumors, Remote sensing, Photoacoustic spectroscopy, Photoacoustic imaging, Diagnostics, Blood, Cancer detection, Biological samples

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Proceedings Article | 13 March 2024 Presentation

Deep ultraviolet transmittance and scattering microscopy for virtual histology

Brendyn Cikaluk, Mohammad Masoumi, Brendon Restall, Matthew Martell, Nathaniel J. Haven, Roger Zemp

Proceedings Volume PC12854, PC128540P (2024) https://doi.org/10.1117/12.3001806

KEYWORDS: Microscopy, Deep ultraviolet, Confocal fluorescent microscopy, Tissues, Scattering, Ultraviolet radiation, Imaging systems, UV optics, Transmittance, Tissue optics

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Proceedings Article | 13 March 2024 Presentation

Combined ultraviolet confocal reflectance, autofluorescence, and photoacoustic remote sensing microscopy for generating virtual sectioned histology in thick tissues

Nathaniel J. Haven, Brendon Restall, Matthew Martell, Brendyn Cikaluk, Roger Zemp

Proceedings Volume PC12842, PC128421K (2024) https://doi.org/10.1117/12.3002864

KEYWORDS: Tissues, Confocal microscopy, Ultraviolet radiation, Reflectivity, Autofluorescence, Remote sensing, Photoacoustic spectroscopy, Resection, Surgery, Microscopy

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Proceedings Article | 13 March 2024 Presentation

Comparing deep ultraviolet transmission microscopy and ultraviolet photoacoustic remote sensing microscopy for thin-tissue histology

Brendyn Cikaluk, Mohammad Masoumi, Nathaniel J. Haven, Matthew Martell, Brendon Restall, Roger Zemp

Proceedings Volume PC12842, PC128421N (2024) https://doi.org/10.1117/12.3002868

KEYWORDS: Microscopy, Ultraviolet radiation, Transmittance, Tissues, Remote sensing, Photoacoustic spectroscopy, Diagnostics, Deep ultraviolet, Target detection, Photoacoustic imaging

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Proceedings Article | 11 August 2023 Open Access

Bias-Sensitive 128x128 hand-held TOBE ultrasound probe based on electrostrictive PMN-PT for photoacoustic applications (Withdrawal Notice)

Mohammad Rahim Sobhani, Mahyar Ghavami, Roger Zemp

Proceedings Volume 12631, 126310V (2023) https://doi.org/10.1117/12.2671017

KEYWORDS: Ultrasonography, Photoacoustic spectroscopy, Industrial applications, Imaging arrays, Opacity, Lead, Ultrasound transducers, Transparency, Stereoscopy, Spatial resolution

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Proceedings Article | 11 August 2023 Paper

Utilizing a ten million frames-per-second camera to investigate mechanisms responsible for laser pulse-induced reflectivity modulations in photoacoustic remote sensing

Nathaniel J. Haven, Matthew Martell, Haoyang Li, James Hogan, Roger Zemp

Proceedings Volume 12631, 1263103 (2023) https://doi.org/10.1117/12.2670970

KEYWORDS: Modulation, Remote sensing, Photoacoustic spectroscopy, Cameras, Water, Gold, Photoacoustic imaging, Microscopy, Refractive index, Contrast agents

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Proceedings Article | 11 August 2023 Paper

Ultraviolet photoacoustic remote sensing and scattering microscopy for CycleGAN-enabled realistic virtual histology

Matthew Martell, Nathaniel J. Haven, Ewan McAlister, Brendon Restall, Brendyn Cikaluk, Rohan Mittal, Benjamin Adam, Nadia Giannakopoulos, Lashan Peiris, Sveta Silverman, Jean Deschenes, Xingyu Li, Roger Zemp

Proceedings Volume 12631, 126310C (2023) https://doi.org/10.1117/12.2671022

KEYWORDS: Tissues, Ultraviolet radiation, Scattering, Remote sensing, Photoacoustic spectroscopy, Microscopy, Breast, Surgery, Gold, Diagnostics

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Proceedings Article | 16 March 2023 Presentation

Prostate needle biopsy metabolic analysis and virtual H&E microscopy using photoacoustic remote sensing and autofluorescence microscopy (Conference Presentation)

Brendon Restall, Brendyn Cikaluk, Matthew Martell, Nathaniel J. Haven, Adam Kinnaird, Roger Zemp

Proceedings Volume PC12391, PC123910P (2023) https://doi.org/10.1117/12.2650688

KEYWORDS: Microscopy, Remote sensing, Photoacoustic spectroscopy, Biopsy, Prostate, Biological research, Genomics, Cancer, Prostate cancer, Image quality

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Proceedings Article | 9 March 2023 Presentation

Combined ultraviolet confocal reflectance and photoacoustic remote sensing microscopy for generating virtual sectioned histology

Nathaniel J. Haven, Matthew Martell, Jean Deschenes, Lashan Peiris, Nadia Giannakopoulos, Roger Zemp

Proceedings Volume PC12379, PC123791T (2023) https://doi.org/10.1117/12.2650881

KEYWORDS: Confocal microscopy, Ultraviolet radiation, Microscopy, Reflectivity, Remote sensing, Photoacoustic spectroscopy, Tissue optics, Absorption, Tissues, Objectives

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Proceedings Article | 9 March 2023 Presentation

Rapid virtual histology of fresh tissue via photoacoustic remote sensing microscopy and a voice-coil scanning stage

Brendyn Cikaluk, Brendon Restall, Matthew Martell, Nathaniel J. Haven, Roger Zemp

Proceedings Volume PC12379, PC123791V (2023) https://doi.org/10.1117/12.2649205

KEYWORDS: Remote sensing, Photoacoustic spectroscopy, Microscopy, Tissue optics, Ultraviolet radiation, Imaging systems, UV optics, Tumors, Tissues, Scattering

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Proceedings Article | 9 March 2023 Presentation

Photoacoustic remote sensing combined with autofluorescence surface excitation for virtual histology and metabolism imaging

Brendon Restall, Brendyn Cikaluk, Matthew Martell, Nathaniel J. Haven, Roger Zemp

Proceedings Volume PC12379, PC123791Q (2023) https://doi.org/10.1117/12.2649338

KEYWORDS: Remote sensing, Photoacoustic spectroscopy, Cancer, Mode conditioning cables, Tumors, Solids, Receptors, Optical testing, Molecules, Absorption

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Proceedings Article | 9 March 2023 Presentation

Multimodal imaging with ultraviolet photoacoustic remote sensing and interferometric synthetic aperture microscopy

Matthew Martell, Nathaniel J. Haven, Brendon Restall, Roger Zemp

Proceedings Volume PC12367, PC123670V (2023) https://doi.org/10.1117/12.2651039

KEYWORDS: Ultraviolet radiation, Synthetic aperture microscopy, Remote sensing, Photoacoustic spectroscopy, Interferometry, Tissues, Multimodal imaging, UV optics, Scattering, Optical coherence tomography

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Proceedings Article | 7 March 2022 Presentation

Towards high-speed widefield ultraviolet photoacoustic remote sensing microscopy via voice-coil stage scanning and an on-demand pulsed laser

Brendyn Cikaluk, Brendon Restall, Nathaniel J. Haven, Matthew Martell, Roger Zemp

Proceedings Volume PC11960, PC119602M (2022) https://doi.org/10.1117/12.2610286

KEYWORDS: Ultraviolet radiation, Pulsed laser operation, Remote sensing, Photoacoustic spectroscopy, Tissues, Absorption, Surgery, Scattering, Reflectivity, Modulation

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Proceedings Article | 7 March 2022 Poster + Presentation

OCT-guided contour scanning for dynamically-focused photoacoustic remote sensing microscopy

Matthew Martell, Nathaniel J. Haven, Sveta Silverman, Lashan Peiris, Jean Deschenes, Roger Zemp

Proceedings Volume PC11960, PC119601K (2022) https://doi.org/10.1117/12.2610457

KEYWORDS: Microscopy, Remote sensing, Photoacoustic spectroscopy, Tissues, Natural surfaces, Surgery, Scattering, Optical coherence tomography, Breast, Ultraviolet radiation

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Proceedings Article | 7 March 2022 Presentation

Improving the histological realism of ultraviolet photoacoustic remote sensing microscopy images using a deep learning-based generative adversarial network

Matthew Martell, Ewan McAlister, Nathaniel J. Haven, Sveta Silverman, Lashan Peiris, Jean Deschenes, Xingyu Li, Roger Zemp

Proceedings Volume PC11960, PC1196013 (2022) https://doi.org/10.1117/12.2610461

KEYWORDS: Microscopy, Ultraviolet radiation, Remote sensing, Photoacoustic spectroscopy, Oncology, Cancer, Visualization, Tissues, Solids, Scattering

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Proceedings Article | 7 March 2022 Presentation

Rapid virtual H&E photoacoustic remote sensing using constant velocity and galvanometer mirror scanning

Brendon Restall, Brendyn Cikaluk, Nathaniel J. Haven, Matthew Martell, Sveta Silverman, Lashan Peiris, Jean Deschenes, Roger Zemp

Proceedings Volume PC11960, PC1196024 (2022) https://doi.org/10.1117/12.2610322

KEYWORDS: Remote sensing, Photoacoustic spectroscopy, Mirrors, Tissues, Ultraviolet radiation, Tissue optics, Surgery, Prostate, Optical microscopy, Microscopy

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Proceedings Article | 7 March 2022 Presentation

Ultraviolet scattering and photoacoustic remote sensing (sPARS) microscopy for virtual H&E histology

Nathaniel J. Haven, Matthew Martell, Brendyn Cikaluk, Brendon Restall, Ewan McAlister, Roger Zemp, Sveta Silverman, Lashan Peiris, Jean Deschenes, Xingyu Li

Proceedings Volume PC11960, PC1196005 (2022) https://doi.org/10.1117/12.2610317

KEYWORDS: Ultraviolet radiation, Scattering, Remote sensing, Photoacoustic spectroscopy, Microscopy, Laser scattering, Gold, Standards development, Image resolution, Tumors

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Proceedings Article | 7 March 2022 Presentation

Virtual hematoxylin and eosin histopathology with ultraviolet photoacoustic remote sensing and synthetic aperture optical coherence microscopy

Matthew Martell, Nathaniel J. Haven, Brendon Restall, Sveta Silverman, Lashan Peiris, Jean Deschenes, Roger Zemp

Proceedings Volume PC11960, PC1196006 (2022) https://doi.org/10.1117/12.2610470

KEYWORDS: Ultraviolet radiation, Remote sensing, Photoacoustic spectroscopy, Optical coherence tomography, Optical coherence microscopy, Microscopy, Image resolution, Tissue optics, Scattering, UV optics

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Proceedings Article | 7 March 2022 Presentation

Through-illumination photoacoustic imaging using flexible transparent CMUT arrays

Mahyar Ghavami, Afshin Kashani Ilkhechi, Roger Zemp

Proceedings Volume PC11960, PC119602H (2022) https://doi.org/10.1117/12.2610344

KEYWORDS: Photoacoustic spectroscopy, Wafer bonding, Transducers, Ultrasonography, Transparency, Semiconducting wafers, Photoacoustic imaging, Signal to noise ratio, Reliability, Polymers

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Proceedings Article | 7 March 2022 Presentation

Towards high-speed camera-based parallelized widefield photoacoustic remote sensing microscopy

Nathaniel J. Haven, Matthew Martell, Haoyang Li, James Hogan, Roger Zemp, Brendon Restall

Proceedings Volume PC11960, PC119602C (2022) https://doi.org/10.1117/12.2610350

KEYWORDS: Cameras, Microscopy, Remote sensing, Photoacoustic spectroscopy, High speed cameras, Modulation, Image resolution, Fiber optic illuminators, Wavefronts, Reflectivity

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Proceedings Article | 9 December 2021 Paper

Transparent capacitive micromachined ultrasound transducer arrays for multimodal imaging systems

Afshin Kashani Ilkhechi, Roger Zemp

Proceedings Volume 11923, 119230G (2021) https://doi.org/10.1117/12.2615883

KEYWORDS: Ultrasonography, Transducers, Endoscopy, Imaging systems, Photoacoustic imaging, Tissue optics, Scanners, Imaging arrays, Cameras, Transparency

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Proceedings Article | 9 December 2021 Paper

Virtual histological assessment of human breast tumor specimens using spectral-domain optical coherence tomography augmented with ultraviolet photoacoustic remote sensing microscopy

Matthew Martell, Nathaniel J. Haven, Brendon Restall, Pradyumna Kedarisetti, Lashan Peiris, Sveta Silverman, Jean Deschenes, Roger Zemp

Proceedings Volume 11923, 1192312 (2021) https://doi.org/10.1117/12.2615989

KEYWORDS: Tissues, Optical coherence tomography, Tumors, Ultraviolet radiation, Tissue optics, Breast, Scattering, Microscopy, Remote sensing, Photoacoustic spectroscopy

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Proceedings Article | 7 December 2021 Paper

Depth-resolved hematoxylin and eosin virtual histopathology with photoacoustic remote sensing and scattering microscopy

Brendon Restall, Nathaniel J. Haven, Matthew Martell, Pradyumna Kedarisetti, Brendyn Cikaluk, Sveta Silverman, Lashan Peiris, Jean Deschenes, Roger Zemp

Proceedings Volume 11922, 119220S (2021) https://doi.org/10.1117/12.2615728

KEYWORDS: Tissues, Scattering, Microscopy, Surgery, Remote sensing, Photoacoustic spectroscopy, Imaging systems, Breast, Absorption, Lung

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Proceedings Article | 7 December 2021 Paper

Fast analysis of resected breast tissue margins using ultraviolet photoacoustic remote sensing microscopy

Brendyn Cikaluk, Matthew Martell, Nathaniel J. Haven, Brendon Restall, Roger Zemp

Proceedings Volume 11922, 1192219 (2021) https://doi.org/10.1117/12.2615795

KEYWORDS: Tissues, Tissue optics, Microscopy, Photoacoustic spectroscopy, Ultraviolet radiation, Remote sensing, Breast, Surgery, Tumors, Breast cancer

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SPIE Journal Paper | 15 September 2021 Open Access

Multimodal 3D photoacoustic remote sensing and confocal fluorescence microscopy imaging

Brendon S. Restall, Pradyumna Kedarisetti, Nathaniel J. Haven, Matthew Martell, Roger Zemp

JBO, Vol. 26, Issue 09, 096501, (September 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.9.096501

KEYWORDS: Luminescence, Tissues, Confocal microscopy, Imaging systems, Microscopy, Absorption, Photoacoustic spectroscopy, 3D image processing, Remote sensing, 3D photoacoustic microscopy

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SPIE Journal Paper | 23 June 2021 Open Access

Fiber-based photoacoustic remote sensing microscopy and spectral-domain optical coherence tomography with a dual-function 1050-nm interrogation source

Matthew Martell, Nathaniel J. Haven, Roger Zemp

JBO, Vol. 26, Issue 06, 066502, (June 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.6.066502

KEYWORDS: Optical coherence tomography, Imaging systems, Microscopy, Light sources, Mirrors, Photoacoustic spectroscopy, Remote sensing, Absorption, Integrated optics, Photodiodes

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Significance: Spectral-domain optical coherence tomography (SD-OCT) offers depth-resolved imaging of optical scattering contrast but is limited in sensitivity to optical absorption. Dual-modality imaging combined with the noncontact absorption contrast of photoacoustic remote sensing (PARS) microscopy can augment SD-OCT applications with specific molecular and functional contrasts in an all-optical, fiber-based platform. Aim: To develop a fiber-based multimodal PARS and SD-OCT imaging system, which efficiently uses a common 1050-nm light source for SD-OCT and PARS interrogation. Approach: PARS microscopy has predominantly utilized a 1310-nm interrogation light source to date. Hence, a recent dual-modality PARS and 1050-nm SD-OCT imaging system required three distinct wavelengths including a 532-nm PARS excitation, necessitating a free-space optical architecture with discrete subsystems. Here, we validate the first use of a 1050-nm interrogation wavelength for PARS. This enables the transition to fiber-based interferometry as is standard in modern SD-OCT systems, though infeasible with inclusion of an additional 1310-nm wavelength. PARS interrogation functionality is integrated using a broadband optical circulator. Results: Dual-modality imaging is demonstrated in carbon fiber phantoms and a mouse ear in vivo. SD-OCT provided a 4.5-μm lateral resolution, 8.8-μm axial resolution in air, and >101 dB of sensitivity, and PARS contributed 532-nm optical absorption contrast with a 47-dB SNR, and lateral and axial resolutions of 2.4 and 35 μm, respectively. Total interrogation power was reduced from 90% to 58% of the ANSI limit compared to a previous three-wavelength approach. Conclusions: Adapting PARS to use the 1050-nm SD-OCT light source for interrogation enabled implementation of a fiber-based dual-modality system configuration, with image quality maintained. This will facilitate development of potential applications demanding handheld, catheter-based, or endoscopic form factors.

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Proceedings Article | 5 March 2021 Presentation

Comprehensive evaluation of ex vivo and in vivo tissues with ultraviolet photoacoustic remote sensing virtual histology and spectral-domain optical coherence tomography

Matthew Martell, Nathaniel J. Haven, Brendon Restall, Pradyumna Kedarisetti, Roger Zemp

Proceedings Volume 11642, 116422W (2021) https://doi.org/10.1117/12.2578954

KEYWORDS: Tissues, Optical coherence tomography, In vivo imaging, Ultraviolet radiation, Remote sensing, Photoacoustic spectroscopy, Tumors, Tissue optics, Natural surfaces, UV optics

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Proceedings Article | 5 March 2021 Presentation

Label-free virtual H&E histopathology using f-mode ultraviolet photoacoustic remote sensing

Pradyumna Kedarisetti, Nathaniel J. Haven, Brendon Restall, Matthew Martell, Roger Zemp

Proceedings Volume 11642, 116422S (2021) https://doi.org/10.1117/12.2578545

KEYWORDS: Photoacoustic spectroscopy, Ultraviolet radiation, Remote sensing, Image restoration, Scattering, Principal component analysis, Photoacoustic microscopy, Microscopy, Electronic filtering

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Proceedings Article | 5 March 2021 Presentation

High sensitivity transparent capacitive micromachined ultrasound transducer linear arrays for optical, photoacoustic and ultrasound imaging

Afshin Kashani Ilkhechi, Christopher Ceroici, Roger Zemp

Proceedings Volume 11642, 116421Z (2021) https://doi.org/10.1117/12.2578919

KEYWORDS: Ultrasonography, Transducers, Photoacoustic imaging, Photoacoustic spectroscopy, Optical arrays, Wafer-level optics, Optical imaging, Imaging systems, Imaging arrays, Image resolution

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Proceedings Article | 5 March 2021 Presentation

Towards non-contact functional oxygen metabolism estimation with multi-wavelength photoacoustic remote sensing and Doppler optical coherence tomography

Matthew Martell, Nathaniel J. Haven, Pradyumna Kedarisetti, Roger Zemp, Brendon Restall

Proceedings Volume 11642, 1164233 (2021) https://doi.org/10.1117/12.2578942

KEYWORDS: Optical coherence tomography, Oxygen, Remote sensing, Photoacoustic spectroscopy, Doppler tomography, Mode conditioning cables, In vivo imaging, Image resolution, Structural imaging, Tissues

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Proceedings Article | 5 March 2021 Presentation

Photoacoustic remote sensing 3D H&E histology with fluorescence validation

Brendon Restall, Nathaniel J. Haven, Matthew Martell, Pradyumna Kedarisetti, Brendyn Cikaluk, Lashan Peiris, Sveta Silverman, Jean Deschenes, Roger Zemp

Proceedings Volume 11642, 1164231 (2021) https://doi.org/10.1117/12.2578944

KEYWORDS: Remote sensing, Photoacoustic spectroscopy, Tissues, UV optics, Tissue optics, Refractive index, Reflectivity, Confocal microscopy, Luminescence, Microscopy

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Proceedings Article | 21 August 2020 Presentation

Ultraviolet photoacoustic remote sensing for virtual histopathology

Roger Zemp

Proceedings Volume 11466, 114660H (2020) https://doi.org/10.1117/12.2571084

KEYWORDS: Photoacoustic spectroscopy, Ultraviolet radiation, Remote sensing, Modulation, Tissues, Tumors, Surgery, Laser scattering, Scattering, Tissue optics

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Proceedings Article | 6 March 2020 Presentation

Combined spectral-domain optical coherence tomography and photoacoustic remote sensing microscopy* (Conference Presentation)

Matthew Martell, Cory Rewcastle, Roger Zemp

Proceedings Volume 11240, 112401V (2020) https://doi.org/10.1117/12.2545244

KEYWORDS: Optical coherence tomography, Microscopy, Photoacoustic spectroscopy, Remote sensing, Absorption, Image resolution, Imaging systems, Interferometry, Scattering, Optical imaging

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Proceedings Article | 17 February 2020 Paper

Multispectral photoacoustic remote sensing microscopy using 532nm and 266nm excitation wavelengths

Brendon Restall, Nathaniel Haven, Pradyumna Kedarisetti, Roger Zemp

Proceedings Volume 11240, 112404C (2020) https://doi.org/10.1117/12.2546410

KEYWORDS: Microscopy, In vivo imaging, Signal to noise ratio, Photoacoustic spectroscopy, Absorption, Ultraviolet radiation, Tissue optics, Image resolution, Remote sensing

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Proceedings Article | 19 July 2019 Paper

Camera-based photoacoustic remote sensing microscopy

Min Choi, Roger Zemp

Proceedings Volume 11077, 110771R (2019) https://doi.org/10.1117/12.2526858

KEYWORDS: Cameras, Absorption, Photoacoustic spectroscopy, Remote sensing, Microscopy, Laser scattering, Refractive index, Scattering, Tissue optics, Modulation

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Proceedings Article | 4 March 2019 Presentation

Label-free non-contact imaging of cell nuclei using ultraviolet photoacoustic remote sensing microscopy (Conference Presentation)

Nathaniel J. Haven, Kevan Bell, Pradyumna Kedarisetti, Parsin Haji Reza, John Lewis, Roger Zemp

Proceedings Volume 10878, 108781X (2019) https://doi.org/10.1117/12.2508036

KEYWORDS: Microscopy, Ultraviolet radiation, Photoacoustic spectroscopy, Remote sensing, Surgery, Cancer, Confocal microscopy, Tumors, Gold, UV optics

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SPIE Journal Paper | 17 October 2018 Open Access

In vivo photoacoustic difference-spectra imaging of bacteria using photoswitchable chromoproteins

Ryan K. W. Chee, Yan Li, Wei Zhang, Robert Campbell, Roger J. Zemp

JBO, Vol. 23, Issue 10, 106006, (October 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.10.106006

KEYWORDS: In vivo imaging, Absorption, Proteins, Multiplexing, Photoacoustic spectroscopy, Photoacoustic imaging, Bacteria, Imaging systems, Signal to noise ratio, Molecular imaging

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Proceedings Article | 15 March 2018 Presentation

Multiplexed in vivo photoacoustic imaging of photoswitchable chromoproteins GAF2 and BphP1 with difference spectra differentiation (Conference Presentation)

Ryan Chee, Yan Li, Robert Campbell, Roger Zemp

Proceedings Volume 10494, 104942F (2018) https://doi.org/10.1117/12.2290861

KEYWORDS: Photoacoustic spectroscopy, Photoacoustic imaging, In vivo imaging, Multiplexing, Absorption, Imaging systems, Molecular imaging

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Proceedings Article | 15 March 2018 Presentation

Super-resolution photoacoustic imaging of sparse absorbers using L1-norm minimization (Conference Presentation)

David Egolf, Ryan Chee, Golam Chowdhury, Roger Zemp

Proceedings Volume 10494, 104942R (2018) https://doi.org/10.1117/12.2287204

KEYWORDS: Super resolution, Photoacoustic spectroscopy, Ultrasonography, Photoacoustic imaging, Image resolution, Data modeling, Data acquisition, Convex optimization, Acoustics, Optimization (mathematics)

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Proceedings Article | 15 March 2018 Presentation

Coherence-gated photoacoustic remote sensing microscopy (Conference Presentation)

Kevan Bell, Parsin Hajireza, Roger Zemp

Proceedings Volume 10494, 1049422 (2018) https://doi.org/10.1117/12.2288574

KEYWORDS: Photoacoustic spectroscopy, Microscopy, Remote sensing, Optical coherence tomography, Absorption, Reflectivity, Optical resolution, Optical microscopy, In vivo imaging, Signal to noise ratio

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Proceedings Article | 14 March 2018 Presentation

Design and fabrication of capacitive micromachined optical focusing deformable MEMS mirrors for ultrafast tunable focusing (Conference Presentation)

Afshin Kashani Ilkhechi, Benjamin Greenlay, Christopher Ceroici, Mohammad Maadi, Parsin Hajireza, Roger Zemp

Proceedings Volume 10545, 1054512 (2018) https://doi.org/10.1117/12.2290996

KEYWORDS: Microelectromechanical systems, Transient nonlinear optics, Mirrors, Deformable mirrors, Circuit switching, Systems modeling, Finite element methods, Ultrafast phenomena, Adaptive optics, Gaussian beams

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Proceedings Article | 19 February 2018 Presentation + Paper

Bias-sensitive crossed-electrode relaxor 2D arrays for 3D photoacoustic imaging

Chris Ceroici, Katherine Latham, Ryan Chee, Jeremy Brown, Roger Zemp

Proceedings Volume 10494, 1049420 (2018) https://doi.org/10.1117/12.2288854

KEYWORDS: Photoacoustic imaging, 3D image processing, Photoacoustic spectroscopy, Signal to noise ratio, Tissue optics, Transducers, 3D image reconstruction, Electrodes, Scattering

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SPIE Journal Paper | 19 February 2018 Open Access

Tissue perfusion rate estimation with compression-based photoacoustic-ultrasound imaging (Erratum)

Min Choi, A. M. James Shapiro, Roger Zemp

JBO, Vol. 23, Issue 02, 029801, (February 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.2.029801

KEYWORDS: Tissue optics, Biomedical optics, Biological research, Computer engineering, Surgery, Medicine, Dentistry, Human subjects, Visualization, Signal detection

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Proceedings Article | 19 February 2018 Presentation + Paper

Toward wide-field high-speed photoacoustic remote sensing microscopy

Logan Snider, Kevan Bell, Parsin Hajireza, Roger Zemp

Proceedings Volume 10494, 1049423 (2018) https://doi.org/10.1117/12.2291036

KEYWORDS: Photoacoustic microscopy, Photoacoustic imaging, Biophotonic applications, Real time imaging, In vivo imaging, Sensors, Mirrors, Diodes, Photoacoustic spectroscopy, Microscopy, Imaging systems, Image processing, Capacitors, Image quality, Remote sensing

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SPIE Journal Paper | 18 January 2018 Open Access

Tissue perfusion rate estimation with compression-based photoacoustic-ultrasound imaging

Min Choi, A.M. James Shapiro, Roger Zemp

JBO, Vol. 23, Issue 01, 016010, (January 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.1.016010

KEYWORDS: Tissues, Imaging systems, Ultrasonography, Tissue optics, Transducers, Signal detection, Blood, Human subjects, Cancer, Doppler effect

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SPIE Journal Paper | 18 January 2018 Open Access

Estimation of cerebral metabolic rate of oxygen consumption using combined multiwavelength photoacoustic microscopy and Doppler microultrasound

Yan Jiang, Roger Zemp

JBO, Vol. 23, Issue 01, 016009, (January 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.1.016009

KEYWORDS: Oxygen, Doppler effect, Photoacoustic spectroscopy, Ultrasonography, Brain, Veins, Arteries, In vivo imaging, Tissues, Blood

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SPIE Journal Paper | 11 October 2017 Open Access

Photoacoustic imaging of lymphatic pumping

Alex Forbrich, Andrew Heinmiller, Roger Zemp

JBO, Vol. 22, Issue 10, 106003, (October 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.10.106003

KEYWORDS: Lymphatic system, Photoacoustic imaging, Imaging systems, Visualization, Photoacoustic spectroscopy, Tissue optics, Blood, Ultrasonography, Transducers, Tissues

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Proceedings Article | 24 April 2017 Presentation

Temporal evolution of low-coherence reflectometry signals in photoacoustic remote sensing microscopy (Conference Presentation)

Kevan Bell, Parsin Reza, Wei Shi, Roger Zemp

Proceedings Volume 10064, 1006422 (2017) https://doi.org/10.1117/12.2252975

KEYWORDS: Reflectometry, Modulation, Photoacoustic spectroscopy, Microscopy, Remote sensing, Interfaces, 3D modeling, Reflectivity, Absorption, Refractive index

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Proceedings Article | 24 April 2017 Presentation

Photoacoustic and fluorescent imaging GAF2 photoswitchable chromoproteins (Conference Presentation)

Ryan Chee, Yan Li, Robert Paproski, Robert Campbell, Roger Zemp

Proceedings Volume 10064, 100642A (2017) https://doi.org/10.1117/12.2250225

KEYWORDS: Multiplexing, Photoacoustic imaging, Photoacoustic spectroscopy, Luminescence, Molecular imaging, In vivo imaging, Visualization, Imaging systems, Bacteria, Lithium

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Proceedings Article | 24 April 2017 Presentation

Multimodality molecular imaging and extracellular vesicle release based genetic profiling with porphyrin nanodroplets (Conference Presentation)

Roger Zemp, Robert Paproski

Proceedings Volume 10064, 100642F (2017) https://doi.org/10.1117/12.2253254

KEYWORDS: Molecular imaging, Genetics, Profiling, Nanodroplets, Photoacoustic imaging, Luminescence, Absorption, Tissues, Therapeutics, In vivo imaging

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Proceedings Article | 24 April 2017 Presentation

Non-interferometric deep optical resolution photoacoustic remote sensing microscopy (Conference Presentation)

Parsin HajiReza, Kevan Bell, Wei Shi, Roger Zemp

Proceedings Volume 10064, 1006420 (2017) https://doi.org/10.1117/12.2252972

KEYWORDS: Optical resolution, Remote sensing, Microscopy, In vivo imaging, Photoacoustic spectroscopy, Photoacoustic microscopy, Confocal microscopy, Absorption, Signal to noise ratio, Objectives

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Proceedings Article | 3 March 2017 Paper

Photoacoustic remote sensing microscopy with lock-in amplification

Wei Shi, Parsin Hajireza, Kevan Bell, Roger Zemp

Proceedings Volume 10064, 1006447 (2017) https://doi.org/10.1117/12.2253195

KEYWORDS: Signal to noise ratio, Photoacoustic imaging, Photoacoustic spectroscopy, Remote sensing, Image resolution, Microscopy, Laser beam diagnostics, Refractive index, Pulsed laser operation, Interference (communication), Fiber lasers, Signal detection, Laser energy

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Proceedings Article | 3 March 2017 Paper

Compression-tracking photoacoustic perfusion and microvascular pressure measurements

Min Choi, Roger Zemp

Proceedings Volume 10064, 100643R (2017) https://doi.org/10.1117/12.2253287

KEYWORDS: Tissues, Photoacoustic spectroscopy, Photoacoustic imaging, Ultrasonography, Imaging systems, Blood pressure, Blood, In vivo imaging, Tissue optics, Human subjects, Data modeling, Image processing, Data acquisition

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SPIE Journal Paper | 6 June 2016 Open Access

Photoacoustic imaging of angiogenesis in a subcutaneous islet transplant site in a murine model

Wei Shi, Rena Pawlick, Antonio Bruni, Yasmin Rafiei, Andrew Pepper, Boris Gala Lopez, Min Choi, Andrew Malcolm, Roger Zemp, A. M. James Shapiro

JBO, Vol. 21, Issue 06, 066003, (June 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.6.066003

KEYWORDS: Photoacoustic imaging, Information technology, Tissue optics, Photoacoustic spectroscopy, 3D image processing, Transplantation, Imaging systems, Veins, Quantitative analysis, Transducers

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Proceedings Article | 27 April 2016 Presentation

Signal mechanisms in photoacoustic remote sensing microscopy (Conference Presentation)

Roger Zemp, W. Shi, Parsin Haji Reza

Proceedings Volume 9708, 97082I (2016) https://doi.org/10.1117/12.2211472

KEYWORDS: Modulation, Photoacoustic spectroscopy, Remote sensing, Microscopy, Confocal microscopy, Laser beam diagnostics, Signal to noise ratio, Optimization (mathematics), Photons, Ultrasonography

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Proceedings Article | 27 April 2016 Presentation

Multi-scale photoacoustic remote sensing (PARS) (Conference Presentation)

Parsin Haji Reza, Kevan Bell, W. Shi, Roger Zemp

Proceedings Volume 9708, 97082F (2016) https://doi.org/10.1117/12.2211467

KEYWORDS: Photoacoustic spectroscopy, Imaging systems, Acoustics, Remote sensing, Optical resolution, In vivo imaging, Image resolution, Tissue optics, Ultrasonography, Natural surfaces

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Proceedings Article | 27 April 2016 Presentation

Engineering a near-infrared dark chromoprotein optimized for photoacoustic imaging (Conference Presentation)

Yan Li, Quinn Barber, Robert Paproski, Jhon Enterina, Erik Rodriguez, Roger Tsien, Robert Campbell, Roger Zemp

Proceedings Volume 9708, 97081Z (2016) https://doi.org/10.1117/12.2209150

KEYWORDS: Photoacoustic imaging, Photoacoustic spectroscopy, Absorption, Imaging systems, Visual process modeling, Luminescence, Quantum efficiency, Near infrared, Fluorescent proteins, Proteins

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Proceedings Article | 18 March 2016 Presentation + Paper

Relative microvascular pressure sensing

Min Choi, Roger Zemp

Proceedings Volume 9708, 97081D (2016) https://doi.org/10.1117/12.2213607

KEYWORDS: Tissues, Photoacoustic spectroscopy, Visualization, Ultrasonography, Photoacoustic imaging, Photoacoustic microscopy, Capillaries, Blood, Imaging systems, Blood pressure, Transducers, Sensors, Detection and tracking algorithms

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Proceedings Article | 18 March 2016 Presentation + Paper

Photoacoustic imaging of angiogenesis in subdermal islet transplant sites

Wei Shi, Rena Pawlick, Antonio Bruni, Yasmin Rafiei, Andrew Pepper, Boris Gala-Lopez, Min Choi, Andrew Malcolm, Roger Zemp, A. M. James Shapiro

Proceedings Volume 9708, 97080Q (2016) https://doi.org/10.1117/12.2211247

KEYWORDS: Transplantation, Photoacoustic imaging, Imaging systems, Veins, Tissue optics, Neodymium

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Proceedings Article | 15 March 2016 Presentation + Paper

Integrated transrectal probe for translational ultrasound-photoacoustic imaging

Kevan Bell, Tyler Harrison, Nawaid Usmani, Roger Zemp

Proceedings Volume 9708, 97080A (2016) https://doi.org/10.1117/12.2211885

KEYWORDS: Photoacoustic imaging, Pulsed laser operation, Tunable lasers, Visualization, Transducers, Imaging systems, Photoacoustic tomography, Photoacoustic spectroscopy, Tissues, Blood, Optical parametric oscillators, Signal to noise ratio, In vivo imaging, Endoscopy, Prostate

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Proceedings Article | 15 March 2016 Paper

Photoacoustic imaging using lock-in amplification and pulsed fiber lasers

Wei Shi, Parsin Hajireza, Roger Zemp

Proceedings Volume 9708, 97084I (2016) https://doi.org/10.1117/12.2211109

KEYWORDS: Photoacoustic imaging, Signal to noise ratio, Fiber lasers, Imaging systems, Pulsed laser operation, Tissue optics, Carbon

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Proceedings Article | 15 March 2016 Paper

Multiple-illumination photoacoustic tomography

Quinn Barber, Roger Zemp

Proceedings Volume 9708, 97084G (2016) https://doi.org/10.1117/12.2209387

KEYWORDS: Ultrasonography, Tomography, Scattering, Photoacoustic tomography, Anisotropy, Photoacoustic spectroscopy, Algorithm development, Photoacoustic imaging, Data modeling, Breast imaging, Transducers, Ultrasound tomography, Absorption, Composites

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SPIE Journal Paper | 25 February 2016 Open Access

Multimodality Raman and photoacoustic imaging of surface-enhanced-Raman-scattering-targeted tumor cells

Wei Shi, Robert Paproski, Peng Shao, Alexander Forbrich, John Lewis, Roger Zemp

JBO, Vol. 21, Issue 02, 020503, (February 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.2.020503

KEYWORDS: Surface enhanced Raman spectroscopy, Nanoparticles, Magnetism, Raman spectroscopy, Tumors, Photoacoustic imaging, Signal detection, Imaging systems, Blood, In vivo imaging

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SPIE Journal Paper | 28 October 2015 Open Access

Monitoring photodynamic therapy with photoacoustic microscopy

Peng Shao, David Chapman, Ronald Moore, Roger Zemp

JBO, Vol. 20, Issue 10, 106012, (October 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.10.106012

KEYWORDS: Photodynamic therapy, Blood vessels, Oxygen, Photoacoustic microscopy, Ear, Picosecond phenomena, Imaging systems, Optical coherence tomography, Tissues, Content addressable memory

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SPIE Journal Paper | 21 October 2015 Open Access

Validating tyrosinase homologue melA as a photoacoustic reporter gene for imaging Escherichia coli

Robert Paproski, Yan Li, Quinn Barber, John Lewis, Robert Campbell, Roger Zemp

JBO, Vol. 20, Issue 10, 106008, (October 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.10.106008

KEYWORDS: Bacteria, Photoacoustic spectroscopy, Tissue optics, Photoacoustic imaging, Scattering, Bioluminescence, Signal detection, Luminescence, Imaging systems, Visualization

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To understand the pathogenic processes for infectious bacteria, appropriate research tools are required for replicating and characterizing infections. Fluorescence and bioluminescence imaging have primarily been used to image infections in animal models, but optical scattering in tissue significantly limits imaging depth and resolution. Photoacoustic imaging, which has improved depth-to-resolution ratio compared to conventional optical imaging, could be useful for visualizing melA-expressing bacteria since melA is a bacterial tyrosinase homologue which produces melanin. Escherichia coli-expressing melA was visibly dark in liquid culture. When melA-expressing bacteria in tubes were imaged with a VisualSonics Vevo LAZR system, the signal-to-noise ratio of a 9× dilution sample was 55, suggesting that ∼20 bacteria cells could be detected with our system. Multispectral (680, 700, 750, 800, 850, and 900 nm) analysis of the photoacoustic signal allowed unmixing of melA-expressing bacteria from blood. To compare photoacoustic reporter gene melA (using Vevo system) with luminescent and fluorescent reporter gene Nano-lantern (using Bruker Xtreme In-Vivo system), tubes of bacteria expressing melA or Nano-lantern were submerged 10 mm in 1% Intralipid, spaced between <1 and 20 mm apart from each other, and imaged with the appropriate imaging modality. Photoacoustic imaging could resolve the two tubes of melA-expressing bacteria even when the tubes were less than 1 mm from each other, while bioluminescence and fluorescence imaging could not resolve the two tubes of Nano-lantern-expressing bacteria even when the tubes were spaced 10 mm from each other. After injecting 100-μL of melA-expressing bacteria in the back flank of a chicken embryo, photoacoustic imaging allowed visualization of melA-expressing bacteria up to 10-mm deep into the embryo. Photoacoustic signal from melA could also be separated from deoxy- and oxy-hemoglobin signal observed within the embryo and chorioallantoic membrane. Our results suggest that melA is a useful photoacoustic reporter gene for visualizing bacteria, and further work incorporating photoacoustic reporters into infectious bacterial strains is warranted.

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Proceedings Article | 12 March 2015 Paper

A non-stochastic iterative computational method to model light propagation in turbid media

Thomas McIntyre, Roger Zemp

Proceedings Volume 9319, 931918 (2015) https://doi.org/10.1117/12.2079656

KEYWORDS: Scattering, Monte Carlo methods, Solids, Absorption, Convolution, Stochastic processes, Diffusion, Matrices, Photon transport, Computer simulations

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Proceedings Article | 11 March 2015 Paper

A tunable MOPA laser for real-time optical resolution photoacoustic microscopy

Mohammad Mahmud, Alex Forbrich, Peng Shao, Wei Shi, Roger Zemp

Proceedings Volume 9323, 93233V (2015) https://doi.org/10.1117/12.2077300

KEYWORDS: Crystals, Imaging systems, Optical resolution, Tunable lasers, Laser systems engineering, Nonlinear crystals, Second-harmonic generation, Carbon, Photoacoustic microscopy, Signal to noise ratio

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Proceedings Article | 11 March 2015 Paper

Validating tyrosinase homologue MelA as a photoacoustic reporter gene for imaging escherichia coli

Robert Paproski, Yan Li, Quinn Barber, John Lewis, Robert Campbell, Roger Zemp

Proceedings Volume 9323, 93232H (2015) https://doi.org/10.1117/12.2079638

KEYWORDS: Bacteria, Photoacoustic spectroscopy, Tissues, Visualization, Blood, Tissue optics, Imaging systems, Photoacoustic imaging, Proteins, Signal detection

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Proceedings Article | 11 March 2015 Paper

Blanket illumination vs scanned-mosaicking imaging schemes for wide-area photoacoustic tomography

Quinn Barber, Tyler Harrison, Roger Zemp

Proceedings Volume 9323, 93232V (2015) https://doi.org/10.1117/12.2079950

KEYWORDS: Signal to noise ratio, Monte Carlo methods, Transducers, Tissues, Photoacoustic tomography, Ultrasonics, Scattering, Acquisition tracking and pointing, Photoacoustic spectroscopy, Laser scattering

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Proceedings Article | 11 March 2015 Paper

Lifetime-weighted photoacoustic imaging

A. Forbrich, P. Shao, Wei Shi, Roger Zemp

Proceedings Volume 9323, 93231H (2015) https://doi.org/10.1117/12.2079815

KEYWORDS: Molecules, Photoacoustic spectroscopy, Photoacoustic imaging, Oxygen, Blood, Acoustics, Ultrasonography, Chromophores, Laser beam diagnostics, Absorption

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SPIE Journal Paper | 17 December 2014 Open Access

Consecutively reconstructing absorption and scattering distributions in turbid media with multiple-illumination photoacoustic tomography

Peng Shao, Tyler Harrison, Roger Zemp

JBO, Vol. 19, Issue 12, 126009, (December 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.12.126009

KEYWORDS: Absorption, Scattering, Diffusion, Signal to noise ratio, Inverse optics, Photoacoustic tomography, Iterative methods, Optical properties, Tissue optics, Geometrical optics

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SPIE Journal Paper | 9 September 2014 Open Access

S-sequence patterned illumination iterative photoacoustic tomography

Tyler Harrison, Peng Shao, Roger Zemp

JBO, Vol. 19, Issue 09, 096004, (September 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.9.096004

KEYWORDS: Signal to noise ratio, Absorption, Computer programming, Photoacoustic tomography, Photoacoustic imaging, Photoacoustic spectroscopy, Image restoration, Inverse optics, Tomography, Ultrasonography

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SPIE Journal Paper | 23 May 2014 Open Access

Detection of circulating tumor cells using targeted surface-enhanced Raman scattering nanoparticles and magnetic enrichment

Wei Shi, Robert Paproski, Ronald Moore, Roger Zemp

JBO, Vol. 19, Issue 05, 056014, (May 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.5.056014

KEYWORDS: Surface enhanced Raman spectroscopy, Magnetism, Raman spectroscopy, Nanoparticles, Target detection, Tumors, Blood, Signal detection, Cancer, Receptors

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Proceedings Article | 3 March 2014 Paper

A consecutive reconstruction strategy for estimating absorption and scattering coefficient distribution in multiple-illumination photoacoustic tomography (MIPAT)

Peng Shao, Tyler Harrison, Roger Zemp

Proceedings Volume 8943, 89433U (2014) https://doi.org/10.1117/12.2040671

KEYWORDS: Absorption, Scattering, Diffusion, Optical properties, Geometrical optics, Photoacoustic tomography, Reconstruction algorithms, Signal to noise ratio, Photoacoustic spectroscopy, Photoacoustic imaging

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Proceedings Article | 3 March 2014 Paper

S-sequence patterned illumination for fixed-point iterative multiple illumination photoacoustic tomography

Tyler Harrison, Peng Shao, Roger Zemp

Proceedings Volume 8943, 89434W (2014) https://doi.org/10.1117/12.2040580

KEYWORDS: Signal to noise ratio, Photoacoustic tomography, Absorption, Computer programming, Image restoration, Scattering, Ultrasonography, Iterative methods, Device simulation, Photoacoustic imaging

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Proceedings Article | 3 March 2014 Paper

Multimodality photoacoustic and Raman imaging of magnetically trapped tumor cells

Wei Shi, Peng Shao, Robert Paproski, Alexander Forbrich, Ronald Moore, Roger Zemp

Proceedings Volume 8943, 89431X (2014) https://doi.org/10.1117/12.2040302

KEYWORDS: Surface enhanced Raman spectroscopy, Raman spectroscopy, Magnetism, Imaging systems, Nanoparticles, Photoacoustic spectroscopy, Tumors, Raman scattering, Blood, Photoacoustic imaging

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Proceedings Article | 3 March 2014 Paper

Real-time clinically oriented array-based in vivo combined photoacoustic and power Doppler imaging

Tyler Harrison, Dean Jeffery, Edward Wiebe, Roger Zemp

Proceedings Volume 8943, 89435A (2014) https://doi.org/10.1117/12.2040609

KEYWORDS: Doppler effect, Ultrasonography, Photoacoustic imaging, In vivo imaging, Photoacoustic spectroscopy, Blood, Imaging systems, Transducers, Tissues, Arteries

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SPIE Journal Paper | 25 September 2013 Open Access

Optical resolution photoacoustic microendoscopy with ultrasound-guided insertion and array system detection

Parsin Hajireza, Tyler Harrison, Alexander Forbrich, Roger Zemp

JBO, Vol. 18, Issue 09, 090502, (September 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.9.090502

KEYWORDS: Photoacoustic spectroscopy, Ultrasonography, Transducers, Endoscopy, Tissues, Optical resolution, Signal to noise ratio, Carbon, Fiber lasers, Mirrors

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SPIE Journal Paper | 4 June 2013 Open Access

Phase-function corrected diffusion model for diffuse reflectance of a pencil beam obliquely incident on a semi-infinite turbid medium

Roger Zemp

JBO, Vol. 18, Issue 06, 067005, (June 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.6.067005

KEYWORDS: Monte Carlo methods, Diffuse reflectance spectroscopy, Diffusion, Scattering, Absorption, Optical properties, Data modeling, Error analysis, Tissue optics, Anisotropy

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Proceedings Article | 25 March 2013 Paper

Efficient Green's function and Jacobian matrix calculations for optical tomography problems near boundaries using phase-function-corrected diffusion theory approximations

Roger Zemp

Proceedings Volume 8578, 857813 (2013) https://doi.org/10.1117/12.2005057

KEYWORDS: Diffusion, Monte Carlo methods, Scattering, Optical tomography, Absorption, Ions, Matrices, Photons, Algorithm development, Tomography

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Proceedings Article | 4 March 2013 Paper

Optical-resolution photoacoustic micro-endoscopy with ultrasound array system detection

Tyler Harrison, Parsin Hajireza, Alexander Forbrich, Roger Zemp

Proceedings Volume 8581, 85810C (2013) https://doi.org/10.1117/12.2004887

KEYWORDS: Ultrasonography, Transducers, Signal to noise ratio, Photoacoustic spectroscopy, Endoscopy, Endoscopes, Carbon, Mirrors, Tissues, Signal detection

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Proceedings Article | 4 March 2013 Paper

In vivo multi-wavelength optical-resolution photoacoustic microscopy with stimulated Raman scattering fiber-laser source

Parsin Hajireza, Alexander Forbrich, Yan Jiang, Wei Shi, Roger Zemp

Proceedings Volume 8581, 858129 (2013) https://doi.org/10.1117/12.2005145

KEYWORDS: Photoacoustic microscopy, In vivo imaging, Fiber lasers, Raman scattering, Imaging systems, Photoacoustic spectroscopy, Functional imaging, Optical resolution, Tissue optics, Absorption

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Proceedings Article | 21 February 2013 Paper

Phase-function corrected diffusion model for diffuse reflectance of a pencil beam obliquely incident on a semi-infinite turbid medium

Roger Zemp

Proceedings Volume 8592, 85920I (2013) https://doi.org/10.1117/12.2005036

KEYWORDS: Diffusion, Monte Carlo methods, Diffuse reflectance spectroscopy, Scattering, Reflectometry, Tissue optics, Optical properties, Cancer, Light scattering, Absorption

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SPIE Journal Paper | 1 February 2013 Open Access

In vivo dynamic process imaging using real-time optical-resolution photoacoustic microscopy

Wei Shi, Peng Shao, Parsin Hajireza, Alexander Forbrich, Roger Zemp

JBO, Vol. 18, Issue 02, 026001, (February 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.2.026001

KEYWORDS: Imaging systems, In vivo imaging, Data acquisition, Fiber lasers, Image processing, Real time imaging, Photoacoustic spectroscopy, Mirrors, Transducers, Ear

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SPIE Journal Paper | 19 July 2012 Open Access

Mosaic acquisition and processing for optical-resolution photoacoustic microscopy

Peng Shao, Wei Shi, Ryan Chee, Roger Zemp

JBO, Vol. 17, Issue 8, 080503, (July 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.8.080503

KEYWORDS: Data acquisition, Imaging systems, Composites, Mirrors, Transducers, Optical scanning, Image processing, Photoacoustic microscopy, Fiber lasers, Ear

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SPIE Journal Paper | 18 July 2012 Open Access

Integrated micro-endoscopy system for simultaneous fluorescence and optical-resolution photoacoustic imaging

Peng Shao, Wei Shi, Parsin Haji Reza, Roger Zemp

JBO, Vol. 17, Issue 7, 076024, (July 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.7.076024

KEYWORDS: Imaging systems, Luminescence, Visualization, Mirrors, System integration, Integrated optics, Semiconductor lasers, Biomedical optics, Fiber lasers, Objectives

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SPIE Journal Paper | 3 April 2012 Open Access

Blood oxygen flux estimation with a combined photoacoustic and high-frequency ultrasound microscopy system: a phantom study

Yan Jiang, Alex Forbrich, Tyler Harrison, Roger Zemp

JBO, Vol. 17, Issue 03, 036012, (April 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.3.036012

KEYWORDS: Oxygen, Blood, Doppler effect, Ultrasonography, Photoacoustic spectroscopy, Imaging systems, Tissues, Biological research, Tissue optics, Microscopy

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Proceedings Article | 23 February 2012 Paper

Inducible expression of photoacoustic reporter gene tyrosinase in cells using a single plasmid

Robert Paproski, Roger Zemp

Proceedings Volume 8223, 82233Y (2012) https://doi.org/10.1117/12.909644

KEYWORDS: Photoacoustic spectroscopy, Photoacoustic imaging, Proteins, Polymers, Manufacturing, Absorption, Ultrasonography, Tissue optics, Cancer, Fetus

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Proceedings Article | 23 February 2012 Paper

Imaging dynamic processes using fiber laser optical-resolution photoacoustic microscopy

Wei Shi, Peng Shao, Parsin Hajireza, Alexander Forbrich, Roger Zemp

Proceedings Volume 8223, 82230Y (2012) https://doi.org/10.1117/12.909130

KEYWORDS: Imaging systems, Fiber lasers, Mirrors, Data acquisition, In vivo imaging, Photoacoustic microscopy, Ear, Image processing, Capillaries, Pulsed laser operation

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Proceedings Article | 23 February 2012 Paper

In vivo imaging with GRIN-lens optical resolution photoacoustic micro-endoscopy

Parsin Hajireza, Wei Shi, Alexander Forbrich, Peng Shao, Roger Zemp

Proceedings Volume 8223, 82230I (2012) https://doi.org/10.1117/12.909058

KEYWORDS: Imaging systems, Photoacoustic spectroscopy, Fiber lasers, In vivo imaging, GRIN lenses, Carbon, Optical resolution, Spatial resolution, Tissues, Mirrors

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Proceedings Article | 23 February 2012 Paper

Mosaicing for fast wide-field-of-view optical resolution photoacoustic microscopy

Peng Shao, Wei Shi, Ryan Chee, Alexander Forbrich, Roger Zemp

Proceedings Volume 8223, 822311 (2012) https://doi.org/10.1117/12.909764

KEYWORDS: Data acquisition, Imaging systems, Mirrors, Photoacoustic microscopy, Optical scanning systems, Composites, Biomedical optics, Image resolution, Transducers, Ultrasonography

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Proceedings Article | 23 February 2012 Paper

In vivo imaging of inducible tyrosinase gene expression with an ultrasound array-based photoacoustic system

Tyler Harrison, Robert Paproski, Roger Zemp

Proceedings Volume 8223, 82230S (2012) https://doi.org/10.1117/12.908987

KEYWORDS: Tumors, Ultrasonography, Imaging systems, In vivo imaging, Photoacoustic spectroscopy, Photoacoustic imaging, Blood, Tissues, Signal to noise ratio, Breast

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Proceedings Article | 23 February 2012 Paper

In vivo combined photoacoustic and Doppler ultrasound imaging

Yan Jiang, Tyler Harrison, Alexander Forbrich, Roger Zemp

Proceedings Volume 8223, 822315 (2012) https://doi.org/10.1117/12.909157

KEYWORDS: Doppler effect, Oxygen, Blood, Ultrasonography, Photoacoustic spectroscopy, In vivo imaging, Doppler tomography, Imaging systems, Arteries, In vitro testing

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Proceedings Article | 23 February 2012 Paper

Combined optical resolution photoacoustic and fluorescence micro-endoscopy

Peng Shao, Wei Shi, Parsin Hajireza, Roger Zemp

Proceedings Volume 8223, 822318 (2012) https://doi.org/10.1117/12.909777

KEYWORDS: Luminescence, Imaging systems, Photoacoustic spectroscopy, Mirrors, Visualization, Image resolution, Objectives, CCD cameras, Semiconductor lasers, Light sources

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SPIE Journal Paper | 1 August 2011 Open Access

Coregistered photoacoustic-ultrasound imaging applied to brachytherapy

Tyler Harrison, Roger Zemp

JBO, Vol. 16, Issue 08, 080502, (August 2011) https://doi.org/10.1117/12.10.1117/1.3606566

KEYWORDS: Ultrasonography, Tissues, Photoacoustic imaging, Prostate, Tissue optics, Photoacoustic spectroscopy, Video, Radiotherapy, Tumors, Transducers

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Proceedings Article | 23 February 2011 Paper

Photoacoustic and Doppler ultrasound for oxygen consumption estimation: implementation on a clinical array system

Yan Jiang, Tyler Harrison, Roger Zemp

Proceedings Volume 7899, 789941 (2011) https://doi.org/10.1117/12.875754

KEYWORDS: Doppler effect, Ultrasonography, Photoacoustic spectroscopy, Imaging systems, Oxygen, Photoacoustic imaging, Blood, Transducers, Tissues, Ultrasonics

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Proceedings Article | 23 February 2011 Paper

Multiple-illumination photoacoustic tomography: reconstructing absorption, scattering, and Grüeneisen coefficient distributions

Peng Shao, Ben Cox, Roger Zemp

Proceedings Volume 7899, 78993Z (2011) https://doi.org/10.1117/12.875728

KEYWORDS: Absorption, Scattering, Optical properties, Photoacoustic spectroscopy, Acquisition tracking and pointing, Photoacoustic tomography, Tissue optics, Geometrical optics, Photoacoustic imaging, Tissues

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Proceedings Article | 23 February 2011 Paper

Real-time optical-resolution photoacoustic microscopy using fiber-laser technology

Wei Shi, Parsin Hajireza, Peng Shao, Shaun Kerr, Roger Zemp

Proceedings Volume 7899, 789939 (2011) https://doi.org/10.1117/12.875130

KEYWORDS: Imaging systems, Mirrors, Fiber lasers, Photoacoustic microscopy, Spatial resolution, Pulsed laser operation, Carbon, Photoacoustic spectroscopy, Ultrasonography, Transducers

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Proceedings Article | 23 February 2011 Paper

Improved depth-of-field photoacoustic microscopy with a custom high-frequency annular array transducer

Huihong Lu, Peng Shao, Janaka Ranasinghesagara, Tim DeWolf, Tyler Harrison, William Gibson, Roger Zemp

Proceedings Volume 7899, 78993R (2011) https://doi.org/10.1117/12.875601

KEYWORDS: Transducers, Ultrasonography, Photoacoustic spectroscopy, Epoxies, Photoacoustic microscopy, Acoustics, Optical simulations, Ferroelectric polymers, Device simulation, Lead

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Proceedings Article | 23 February 2011 Paper

Oxygen consumption estimation with combined color doppler ultrasound and photoacoustic microscopy: a phantom study

Yan Jiang, Tyler Harrison, Alex Forbrich, Roger Zemp

Proceedings Volume 7899, 789942 (2011) https://doi.org/10.1117/12.875786

KEYWORDS: Doppler effect, Ultrasonography, Oxygen, Photoacoustic spectroscopy, Blood, Tissue optics, Tissues, Imaging systems, Photoacoustic imaging, Velocity measurements

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Proceedings Article | 23 February 2011 Paper

Interlaced realtime channel-domain photoacoustic and ultrasound imaging

Tyler Harrison, Roger Zemp

Proceedings Volume 7899, 78993M (2011) https://doi.org/10.1117/12.875507

KEYWORDS: Ultrasonography, Photoacoustic spectroscopy, Imaging systems, Photoacoustic imaging, Phased arrays, Transducers, In vivo imaging, Data acquisition, Image transmission, Optical parametric oscillators

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Proceedings Article | 18 February 2011 Paper

Photoacoustic imaging of brachytherapy seeds using a channel-domain ultrasound array system

Tyler Harrison, Roger Zemp

Proceedings Volume 7899, 78990H (2011) https://doi.org/10.1117/12.875550

KEYWORDS: Ultrasonography, Photoacoustic imaging, Photoacoustic spectroscopy, Tissues, Imaging systems, Transducers, Multichannel imaging systems, Optical parametric oscillators, Computed tomography, Computing systems

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Proceedings Article | 18 February 2011 Paper

Photoacoustic imaging of gene expression using tyrosinase as a reporter gene

Robert Paproski, Alexander Forbrich, Tyler Harrison, Mary Hitt, Roger Zemp

Proceedings Volume 7899, 78991H (2011) https://doi.org/10.1117/12.875197

KEYWORDS: Photoacoustic spectroscopy, Blood, Ultrasonography, Photoacoustic imaging, Imaging systems, Transducers, Signal detection, Tissues, Tissue optics, Absorption

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Proceedings Article | 18 February 2011 Paper

Optical-resolution photoacoustic micro-endoscopy using image-guide fibers and fiber laser technology

P. Hajireza, W. Shi, P. Shao, S. Kerr, R. Zemp

Proceedings Volume 7899, 78990P (2011) https://doi.org/10.1117/12.875127

KEYWORDS: Optical fibers, Photoacoustic spectroscopy, Fiber lasers, Imaging systems, Laser applications, Tissue optics, Image transmission, Optical resolution, Mirrors, Laser systems engineering

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SPIE Journal Paper | 1 September 2010 Open Access

Optical resolution photoacoustic microscopy using novel high-repetition-rate passively Q-switched microchip and fiber lasers

Wei Shi, Shaun Kerr, Ilya Utkin, Janaka Ranasinghesagara, Lei Pan, Yogesh Godwal, Roger Zemp, Robert Fedosejevs

JBO, Vol. 15, Issue 05, 056017, (September 2010) https://doi.org/10.1117/12.10.1117/1.3502661

KEYWORDS: Fiber lasers, Photoacoustic spectroscopy, Mirrors, Pulsed laser operation, Acoustics, Transducers, Photoacoustic microscopy, Laser systems engineering, Photoacoustic imaging, Ultrasonography

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SPIE Journal Paper | 1 September 2010 Open Access

Photoacoustic and high-frequency power Doppler ultrasound biomicroscopy: a comparative study

Yan Jiang, Tyler Harrison, Janaka Ranasinghesagara, Roger Zemp

JBO, Vol. 15, Issue 05, 056008, (September 2010) https://doi.org/10.1117/12.10.1117/1.3491126

KEYWORDS: Doppler effect, Ultrasonography, Blood, Tissues, Photoacoustic spectroscopy, Imaging systems, Transducers, Electronic filtering, Tissue optics, Blood vessels

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SPIE Journal Paper | 1 July 2010 Open Access

Combined photoacoustic and oblique-incidence diffuse reflectance system for quantitative photoacoustic imaging in turbid media

Janaka Ranasinghesagara, Roger Zemp

JBO, Vol. 15, Issue 04, 046016, (July 2010) https://doi.org/10.1117/12.10.1117/1.3470336

KEYWORDS: Photoacoustic spectroscopy, Absorption, Optical properties, Diffuse reflectance spectroscopy, Photoacoustic imaging, Transducers, Laser scattering, Ultrasonography, Tissue optics, Laser tissue interaction

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Proceedings Article | 24 February 2010 Paper

Integrated photoacoustic and oblique incidence diffuse reflectance system for quantitative optical sensing in turbid media

Janaka Ranasinghesagara, Roger Zemp

Proceedings Volume 7564, 756421 (2010) https://doi.org/10.1117/12.842108

KEYWORDS: Photoacoustic spectroscopy, Absorption, Tissue optics, Transducers, Optical properties, Ultrasonography, Prisms, Laser scattering, Scattering, Diffuse reflectance spectroscopy

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Proceedings Article | 24 February 2010 Paper

Fast-scanning ultrasonic-photoacoustic biomicroscope: in vivo performance

Tyler Harrison, Janaka Ranasinghesagara, Huihong Lu, Roger Zemp

Proceedings Volume 7564, 75641X (2010) https://doi.org/10.1117/12.842118

KEYWORDS: Ultrasonography, Photoacoustic spectroscopy, In vivo imaging, Imaging systems, Transducers, Photoacoustic imaging, Control systems, Visualization, Oxygen, Ultrasonics

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Proceedings Article | 24 February 2010 Paper

Monte Carlo modeling for photoacoustic-based transport-regime optical property estimation

Janaka Ranasinghesagara, Roger Zemp

Proceedings Volume 7564, 75640F (2010) https://doi.org/10.1117/12.842038

KEYWORDS: Photoacoustic spectroscopy, Optical properties, Scattering, Tissue optics, Monte Carlo methods, Light scattering, Laser scattering, Inverse optics, Absorption, Geometrical optics

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Proceedings Article | 24 February 2010 Paper

High repetition rate passively Q-switched fiber and microchip lasers for optical resolution photoacoustic imaging

Wei Shi, Ilya Utkin, Janaka Ranasinghesagara, Lei Pan, Yogesh Godwal, Shaun Kerr, Roger Zemp, Robert Fedosejevs

Proceedings Volume 7564, 75640X (2010) https://doi.org/10.1117/12.842533

KEYWORDS: Fiber lasers, Photoacoustic spectroscopy, Pulsed laser operation, Acoustics, Transducers, Ultrasonography, Imaging systems, Photoacoustic microscopy, Prisms, Laser optics

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Proceedings Article | 23 February 2010 Paper

Combined photoacoustic and high-frequency power Doppler ultrasound imaging

Yan Jiang, Tyler Harrison, Janaka Ranasinghesagara, Roger Zemp

Proceedings Volume 7564, 756404 (2010) https://doi.org/10.1117/12.841044

KEYWORDS: Ultrasonography, Doppler effect, Tissues, Photoacoustic spectroscopy, Signal processing, Blood, Tissue optics, Ultrasonics, Transducers, Absorption

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SPIE Journal Paper | 1 July 2009 Open Access

Photoacoustic technique for assessing optical scattering properties of turbid media

Janaka Ranasinghesagara, Yan Jian, Xuhui Chen, Kory Mathewson, Roger Zemp

JBO, Vol. 14, Issue 04, 040504, (July 2009) https://doi.org/10.1117/12.10.1117/1.3200922

KEYWORDS: Photoacoustic spectroscopy, Tissue optics, Ultrasonography, Scattering, Laser scattering, Tissues, Liquids, Light scattering, Soft tissue optics, Acoustics

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Proceedings Article | 25 February 2009 Paper

Development of a fast-scanning combined ultrasound-photoacoustic biomicroscope

Roger Zemp, Huihong Lu, Kory Mathewson, Janaka Ranasinghesagara, Yan Jiang, Andrew Walsh, Xuhui Chen

Proceedings Volume 7177, 717711 (2009) https://doi.org/10.1117/12.809296

KEYWORDS: Ultrasonography, Photoacoustic spectroscopy, Imaging systems, Photoacoustic imaging, Transducers, Ultrasonics, Data acquisition, Tissue optics, Photoacoustic microscopy, Visualization

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Proceedings Article | 25 February 2009 Paper

A photoacoustic method for optical scattering measurements in turbid media

Roger Zemp, Janaka Ranasinghesagara, Yan Jiang, Xuhui Chen, Kory Mathewson

Proceedings Volume 7177, 71770Q (2009) https://doi.org/10.1117/12.809276

KEYWORDS: Photoacoustic spectroscopy, Tissue optics, Tissues, Scattering, Ultrasonography, Prisms, Transducers, Acoustics, Laser scattering, Absorption

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Proceedings Article | 29 February 2008 Paper

Realtime photoacoustic microscopy of murine cardiovascular and respiratory dynamics in vivo

Roger Zemp, Liang Song, Rachel Bitton, K. Kirk Shung, Lihong Wang

Proceedings Volume 6856, 68560G (2008) https://doi.org/10.1117/12.763127

KEYWORDS: Imaging systems, Ultrasonography, Photoacoustic imaging, Visualization, Photoacoustic spectroscopy, Transducers, Photoacoustic microscopy, In vivo imaging, Heart, Data acquisition

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SPIE Journal Paper | 1 March 2007 Open Access

Photoacoustic imaging of lacZ gene expression in vivo

Li Li, Roger Zemp, Gina Lungu, George Stoica, Lihong Wang

JBO, Vol. 12, Issue 02, 020504, (March 2007) https://doi.org/10.1117/12.10.1117/1.2717531

KEYWORDS: Acquisition tracking and pointing, In vivo imaging, Spatial resolution, Tumors, Absorption, Visualization, Photoacoustic spectroscopy, Molecular imaging, Ultrasonics, Photoacoustic imaging

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Proceedings Article | 27 February 2007 Paper

Laser speckle statistics in ultrasound-modulated optical tomography

Roger Zemp, Sava Sakadžić, Chulhong Kim, Lihong Wang

Proceedings Volume 6437, 64371L (2007) https://doi.org/10.1117/12.700547

KEYWORDS: Speckle, Ultrasonography, Acoustics, Modulation, Ultrasound-modulated optical tomography, Ultrasonics, Charge-coupled devices, Tissue optics, Geometrical optics, Scattering

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Proceedings Article | 13 February 2007 Paper

Imaging microvascular dynamics noninvasively with realtime photoacoustic microscopy

Roger Zemp, Rachel Bitton, Meng-Lin Li, K. Kirk Shung, Lihong Wang

Proceedings Volume 6430, 643015 (2007) https://doi.org/10.1117/12.700484

KEYWORDS: Visualization, Photoacoustic microscopy, Photoacoustic spectroscopy, Ultrasonography, Data acquisition, Oscilloscopes, Blood, Transducers, Pulsed laser operation, Spatial resolution

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SPIE Journal Paper | 1 January 2007 Open Access

Photoacoustic imaging of the microvasculature with a high-frequency ultrasound array transducer

Roger Zemp, Rachel Bitton, K. Shung, Meng-Lin Li, George Stoica, Lihong Wang

JBO, Vol. 12, Issue 01, 010501, (January 2007) https://doi.org/10.1117/12.10.1117/1.2709850

KEYWORDS: Ultrasonography, Photoacoustic imaging, Transducers, Skin, Photoacoustic microscopy, Data acquisition, Optical fibers, Imaging systems, Visualization, Photography

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Proceedings Article | 6 March 2006 Paper

Imaging of gene expression in vivo with photoacoustic tomography

Li Li, Roger Zemp, Gina Lungu, George Stoica, Lihong Wang

Proceedings Volume 6086, 608608 (2006) https://doi.org/10.1117/12.646322

KEYWORDS: In vivo imaging, Absorption, Tumors, Photoacoustic tomography, Photoacoustic spectroscopy, Tissue optics, Blood, Visualization, Biology, Ultrasonics

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Proceedings Article | 6 March 2006 Paper

High-SNR ultrasound-modulated optical tomography with intense acoustic bursts

Chul hong Kim, Roger Zemp, Lihong Wang

Proceedings Volume 6086, 608617 (2006) https://doi.org/10.1117/12.648533

KEYWORDS: Ultrasonography, Acoustics, Ultrasonics, Ultrasound-modulated optical tomography, Charge-coupled devices, Modulation, CCD cameras, Signal to noise ratio, Speckle, Spatial resolution

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Proceedings Article | 6 March 2006 Paper

Fundamental considerations for multiwavelength photoacoustic molecular imaging

Roger Zemp, Li Li, Lihong Wang

Proceedings Volume 6086, 60861L (2006) https://doi.org/10.1117/12.646392

KEYWORDS: Molecular imaging, Photoacoustic spectroscopy, Imaging systems, Modulation transfer functions, Absorption, Photoacoustic tomography, Spatial frequencies, Tissues, Sensors, Transducers

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Proceedings Article | 5 June 2003 Paper

Generalized NEQ for assessment of ultrasound image quality

Roger Zemp, Craig Abbey, Michael Insana

Proceedings Volume 5030, (2003) https://doi.org/10.1117/12.480134

KEYWORDS: Signal to noise ratio, Ultrasonography, Signal detection, Imaging systems, Image quality, Modulation transfer functions, Systems modeling, Target detection, Fourier transforms, Point spread functions

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Proceedings Article | 22 May 2003 Paper

Pre-envelope deconvolution for increased lesion detection efficiency in ultrasonic imaging

Craig Abbey, Roger Zemp, Michael Insana

Proceedings Volume 5034, (2003) https://doi.org/10.1117/12.480099

KEYWORDS: Deconvolution, Ultrasonography, Signal detection, Scattering, Data modeling, Systems modeling, Transducers, Image processing, Demodulation, Convolution

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