Purpose: To compare two detector systems - one based on the charge-coupled device (CCD) and image amplifier, the
other based on a-Si/CsI flat panel, for cone beam computed-tomography (CT) imaging of small animals.
A high resolution, high framing rate detector system for the cone beam CT imaging of small animals was developed. The
system consists of a 2048×3072×12 bit CCD optically coupled to an image amplifier and an x-ray phosphor screen. The
CCD has an intrinsic pixel size of 12 μm but the effective pixel size can be adjusted through the magnification
adjustment of the optical coupling systems. The system is used in conjunction with an x-ray source and a rotating stage
for holding and rotating the scanned object in the cone beam CT imaging experiments. The advantages of the system
include but are not limited to the ability to adjust the effective pixel size and to achieve extremely high spatial resolution
and temporal resolution. However, the need to use optical coupling compromises the detective quanta efficiency (DQE)
of the system. In this paper, the imaging characteristics of the system were presented and compared with those of an a-
Si/CsI flat-panel detector system.
We developed and investigated a scanning sampled measurement (SSM) technique for scatter measurement and
correction in cone beam breast CT imaging. A cylindrical polypropylene phantom (water equivalent) was mounted on a
rotating table in a stationary gantry experimental cone beam breast CT imaging system. A 2-D array of lead beads, with
the beads set apart about ~1 cm from each other and slightly tilted vertically, was placed between the object and x-ray
source. A series of projection images were acquired as the phantom is rotated 1 degree per projection view and the lead
beads array shifted vertically from one projection view to the next. A series of lead bars were also placed at the phantom
edge to produce better scatter estimation across the phantom edges. Image signals in the lead beads/bars shadow were
used to obtain sampled scatter measurements which were then interpolated to form an estimated scatter distribution
across the projection images. The image data behind the lead bead/bar shadows were restored by interpolating image
data from two adjacent projection views to form beam-block free projection images. The estimated scatter distribution
was then subtracted from the corresponding restored projection image to obtain the scatter removed projection images. Our preliminary experiment has demonstrated that it is feasible to implement SSM technique for scatter estimation and
correction for cone beam breast CT imaging. Scatter correction was successfully performed on all projection images
using scatter distribution interpolated from SSM and restored projection image data. The resultant scatter corrected
projection image data resulted in elevated CT number and largely reduced the cupping effects.
Overlapping fibroglandular tissue structures may obscure small calcifications, essential to the early detection of breast cancer. Dual-energy digital mammography (DEDM), where separate low- and high-energy images are acquired and synthesized to cancel the tissue structures, may improve the ability to detect and visualize calcifications amidst fibroglandular structures. We have developed and implemented a DEDM technique under full-field imaging conditions using a commercially available flat-panel based digital mammography system. We have developed techniques to suppress residual structures due to scatter contamination and non-uniformity in the x-ray field and detector response in our DEDM implementation. The total mean-glandular dose from the low- and high-energy images was constrained to be similar to screening examination levels. The low- and high-energy images were combined using a calibrated nonlinear (cubic) mapping function to generate the calcification images. To evaluate the dual-energy calcification images, we have designed a special phantom with calcium carbonate crystals to simulate calcifications of different sizes superimposed with a 5 cm thick breast-tissue-equivalent material with a continuously varying glandular-tissue ratio from 0.0 to 1.0. The suppression of tissue-structure background by dual-energy imaging comes with the cost of increased noise in the dual-energy images. We report on the effects of different image processing techniques on the dual-energy image signal and noise levels. The effects of image processing on the calcification contrast-to-noise ratios are also presented.
This paper investigates the feasibility of using a flat panel based cone-beam computer tomography (CT) system for 3-D breast imaging with computer simulation and imaging experiments. In our simulation study, 3-D phantoms were analytically modeled to simulate a breast loosely compressed into cylindrical shape with embedded soft tissue masses and calcifications. Attenuation coefficients were estimated to represent various types of breast tissue, soft tissue masses and calcifications to generate realistic image signal and contrast. Projection images were computed to incorporate x-ray attenuation, geometric magnification, x-ray detection, detector blurring, image pixelization and digitization. Based on the two-views mammography comparable dose level on the central axis of the phantom (also the rotation axis), x-ray kVp/filtration, transmittance through the phantom, detected quantum efficiency (DQE), exposure level, and imaging geometry, the photon fluence was estimated and used to estimate the phantom noise level on a pixel-by-pixel basis. This estimated noise level was then used with the random number generator to produce and add a fluctuation component to the noiseless transmitted image signal. The noise carrying projection images were then convolved with a Gaussian-like kernel, computed from measured 1-D line spread function (LSF) to simulated detector blurring. Additional 2-D Gaussian-like kernel is designed to suppress the noise fluctuation that inherently originates from projection images so that the reconstructed image detectability of low contrast masses phantom can be improved. Image reconstruction was performed using the Feldkamp algorithm. All simulations were performed on a 24 PC (2.4 GHz Dual-Xeon CPU) cluster with MPI parallel programming. With 600 mrads mean glandular dose (MGD) at the phantom center, soft tissue masses as small as 1 mm in diameter can be detected in a 10 cm diameter 50% glandular 50% adipose or fatter breast tissue, and 2 mm or larger masses are visible in a 100% glandular 0% adipose breast tissue. We also found that the 0.15 mm calcification can be detected for 100μm detector while only 0.2 μm or above are visible for 200 μm detector. Our simulation study has shown that the cone-beam CT breast imaging can provide reasonable good quality and
detectability at a dose level similar to that of two views\mammography. For imaging experiments, a stationary x-ray source and detector, a step motor driven rotating phantom system was constructed to demonstrate cone beam breast CT image. A breast specimen from mastectomy and animal tissue embedded with calcifications were imaged. The resulting images show that 355-425 μm calcifications were visible in images obtained at 77 kVp with a voxel size of 316 μm and a center dose of 600 mrads. 300-315 μm calcifications were visible in images obtained at 60 kVp with a voxel size of 158 μm and a center dose of 3.6 rads.
Slot scanning imaging techniques allow for effective scatter rejection without attenuating primary x-rays. The use of these techniques should generate better image quality for the same mean glandular dose (MGD) or a similar image quality for a lower MGD as compared to imaging techniques using an anti-scatter grid. In this study, we compared a slot scanning digital mammography system (SenoScan, Fisher Imaging Systems, Denver, CO) to a full-field digital mammography (FFDM) system used in conjunction with a 5:1 anti-scatter grid (SenoGraphe 2000D, General Electric Medical Systems, Milwaukee, WI). Images of a contrast-detail phantom (University Hospital Nijmegen, The Netherlands) were reviewed to measure the contrast-detail curves for both systems. These curves were measured at 100%, 71%, 49% and 33% of the reference mean glandular dose (MGD), as determined by photo-timing, for the Fisher system and 100% for the GE system. Soft-copy reading was performed on review workstations provided by the manufacturers. The correct observation ratios (CORs) were also computed and used to compare the performance of the two systems. The results showed that, based on the contrast-detail curves, the performance of the Fisher images, acquired at 100% and 71% of the reference MGD, was comparable to the GE images at 100% of the reference MGD. The CORs for Fisher images were 0.463 and 0.444 at 100% and 71% of the reference MGD, respectively, compared to 0.453 for the GE images at 100% of the reference MGD.
Small microcalcifications essential to the early detection of breast cancer may be obscured by overlapping tissue structures. Dual-energy digital mammography (DEDM), where separate low- and high-energy images are acquired and synthesized to cancel the tissue structures, may improve the ability to detect and visualize microcalcifications. The investigation of DEDM began with a signal-to noise ratio analysis to estimate and relate the noise level in the dual-energy calcification signals to the x-ray spectra, microcalcification size, tissue composition and breast thickness. We investigated various inverse-mapping functions, both linear and non-linear, to estimate the calcification thickness from low- and high-energy measurements. Transmission (calibration) measurements made at two different kVp values for variable aluminum thickness (to simulate calcifications) and variable glandular-tissue ratio for a fixed total tissue thickness were used to determine the coefficients of the inverse-mapping functions by a least-squares analysis. We implemented and evaluated the DEDM technique under narrow-beam geometry. Phantoms, used in the evaluation, were constructed by placing different aluminum strips over breast-tissue-equivalent materials of different compositions. The resulting phantom images consisted of four distinct regions, each with a different combination of aluminum thickness and tissue composition. DEDM with non-linear inverse-mapping functions could successfully cancel the contrast of the tissue-structure background to better visualize the overlapping aluminum strip. We are currently in the process of translating our DEDM techniques into full-field imaging. We have designed special phantoms with variable glandular ratios and variable calcification thicknesses for evaluation of the full-field dual-energy calcification images.
The amorphous silicon (a-Si:H) flat panel imaging systems have recently become commercially available and gained acceptance as promising candidates for implementing digital radiography. In this work, SNRs, CNRs and figure-of-merit, defined as CNR2/SEEs, were measured for a commercial a-Si:H/CsI(Tl) flat-panel digital chest radiography system as a function of the kVp for three different regions in the images of a chest phantom: lung, heart and subphrenic. Using these measurements, issues of image quality and optimal selection of the kVp are discussed.
MARGIE will be a large-area, wide field-of-view, hard x- ray/gamma-ray imaging telescope capable of providing accurate positions for faint gamma-ray bursts in near-real- time and of performing a sensitive survey of both steady and transient cosmic sources. The instrument is designed to image faint bursts at the low-intensity end of the log N - log S distribution. MARGIE was recently selected by NASA for a mission-concept study for an Ultra Long Duration Balloon flight. We describe a program to develop an instrument based on the new detector technology of either cadmium zinc telluride room-temperature semiconductors or pixelated cesium iodide scintillators viewed by fast timing charge- coupled devices.
The FiberGLAST scintillating fiber telescope is a large-area instrument concept for NASA's GLAST program. The detector is designed for high-energy gamma-ray astronomy, and uses plastic scintillating fibers to combine a photon pair tracking telescope and a calorimeter into a single instrument. A small prototype detector has been tested with high energy photons at the Thomas Jefferson National Accelerator Facility. We report on the result of this beam test, including scintillating fiber performance, photon track reconstruction, angular resolution, and detector efficiency.
Keith Rielage, Katsushi Arisaka, Muzaffer Atac, W. Robert Binns, James Buckley, Michael Cherry, Mark Christl, David Cline, Paul Dowkontt, John Epstein, Gerald Fishman, T. Gregory Guzik, Paul Hink, Martin Israel, S. Kappadath, Gerald Karr, Richard Kippen, Daniel Leopold, Mark McConnell, John Macri, Robert Mallozzi, William Paciesas, Thomas Parnell, Geoffrey Pendleton, Surasak Phengchamnan, Yuriy Pischalnikov, Georgia Richardson, James Ryan, John Stacy, Tumay Tumer, Gerald Visser, Donald Wallace, Robert Wilson
A scintillating fiber detector is currently being studied for the NASA Gamma-Ray Large Area Space Telescope (GLAST) mission. This detector utilizes modules composed of a thin converter sheet followed by an x, y plane of scintillating fibers to examine the shower of particles created by high energy gamma-rays interacting in the converter material. The detector is composed of a tracker with 90 such modular planes and a calorimeter with 36 planes. The two major component of this detector are the scintillating fibers and their associated photodetectors. Here we present current status of development and test result of both of these. The Hamamatsu R5900-00-M64 multianode photomultiplier tube (MAPMT) is the baseline readout device. A characterization of this device has been performed including noise, cross- talk, gain variation, vibration, and thermal/vacuum test. A prototype fiber/MAPMT system has been tested at the Center for Advanced Microstructures and Devices at Louisiana State University with a photon beam and preliminary results are presented.
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