Dr. Sandhya Vasudevan Profile

Dr. Sandhya Vasudevan

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Publications (5)

SPIE Journal Paper | 23 October 2021 Open Access

Objective determination of peripheral edema in heart failure patients using short-wave infrared molecular chemical imaging

Aaron Smith, Reina Perez, Aaron Thomas, Shona Stewart, Arash Samiei, Arjun Bangalore, Heather Gomer, Marlena Darr, Robert Schweitzer, Sandhya Vasudevan, Jeffrey Cohen, James Post, Srinivas Murali, Patrick Treado

JBO, Vol. 26, Issue 10, 105002, (October 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.10.105002

KEYWORDS: Short wave infrared radiation, Data modeling, Tissues, RGB color model, Reflectivity, Heart, Absorption, Collagen, Sensors, Infrared radiation

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SPIE Journal Paper | 29 June 2021 Open Access

Broadband diffuse optical spectroscopy of absolute methemoglobin concentration can distinguish benign and malignant breast lesions

Sandhya Vasudevan, Chris Campbell, Fang Liu, Thomas O'Sullivan

JBO, Vol. 26, Issue 06, 065004, (June 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.6.065004

KEYWORDS: Breast, Tissues, Collagen, Tissue optics, Diffuse optical spectroscopy, Absorption, Scattering, Breast cancer, Biopsy, Tumors

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Significance: Noninvasive diffuse optical spectroscopy (DOS) is a promising adjunct diagnostic imaging technique for distinguishing benign and malignant breast lesions. Most DOS approaches require normalizing lesion biomarkers to healthy tissue since major tissue constituents exhibit large interpatient variations. However, absolute optical biomarkers are desirable as it avoids reference measurements which may be difficult or impractical to acquire. Aim: Our goal is to determine whether absolute measurements of minor absorbers such as collagen and methemoglobin (metHb) can successfully distinguish lesions. We hypothesize that metHb would exhibit less interpatient variability and be more suitable as an absolute metric for malignancy. However, we would expect collagen to exhibit more variability, because unlike metHb, collagen is also present in the healthy tissue. Approach: In this retrospective clinical study, 30 lesions with breast imaging reporting and database system score ( BIRADS ) > = 3 (12 benign and 18 malignant) measured with broadband quantitative DOS were analyzed for their oxyhemoglobin (HbO), deoxyhemoglobin (HHb), water, lipids, collagen, metHb concentrations, and optical scattering characteristics. Wilcoxon rank sum test was used to compare benign and malignant lesions for all variables in both normalized and absolute forms. Results: Among all absolute DOS parameters considered, only absolute metHb was observed to be significant for lesion discrimination (0.43 ± 0.18 μM for benign versus 0.87 ± 0.32 μM for malignant, p = 0.0002). Absolute metHb concentration was also determined to be the best predictor of malignancy with an area under the curve of 0.89. Conclusions: Our findings demonstrate that lesion metHb concentration measured by DOS can improve noninvasive optical diagnosis of breast malignancies. Since metHb concentration found in normal breast tissue is extremely low, metHb may be a more direct indicator of malignancy that does not depend on other biomarkers found in healthy tissue with significant variability. Furthermore, absolute parameters require reduced measurement time and can be utilized in cases where healthy reference tissue is not available.

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Proceedings Article | 5 March 2021 Presentation + Paper

Minor tissue absorbers can distinguish benign and malignant breast lesions using broadband quantitative diffuse optical spectroscopy

Sandhya Vasudevan, Christopher Campbell, Fang Liu, Thomas O'Sullivan

Proceedings Volume 11639, 1163906 (2021) https://doi.org/10.1117/12.2578603

KEYWORDS: Diffuse optical spectroscopy, Breast, Tissue optics, Tissues, Collagen, Chromophores, Absorption

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Proceedings Article | 25 February 2020 Presentation + Paper

Spatial frequency domain imaging of hemodynamic parameters in a murine model of hindlimb ischemia

Katherine Leyba, Sandhya Vasudevan, Thomas O'Sullivan, Craig Goergen

Proceedings Volume 11215, 112150C (2020) https://doi.org/10.1117/12.2541944

KEYWORDS: Arteries, Ultrasonography, Near infrared spectroscopy, Ischemia, Blood circulation, Tissue optics, Hemodynamics, Doppler effect, Chromophores, Oxygen

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Proceedings Article | 1 March 2019 Paper

Hyperspectral, hybrid continuous wave and frequency domain diffuse optical tomography in a handheld reflectance geometry for breast cancer diagnostics

Sandhya Vasudevan, Farnoush Forghani, Chris Campbell, Vincent Kitsmiller, Thomas O'Sullivan

Proceedings Volume 10874, 108740J (2019) https://doi.org/10.1117/12.2509111

KEYWORDS: Tumors, Absorption, Tissue optics, Optical properties, Scattering, Diffuse optical tomography, Chromophores, Breast

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