Tumor oxygen depletion plays an important role in the process of Photodynamic Therapy (PDT). The paper focuses
on the improvement of the lighting mode to carry out this cancer therapy more effectively in low oxygen content. The
effect of interstitial lighting was compared with that of continuous lighting in different oxygen density measured with a
homemade device in PDT. 90 mice were divided into 3 groups: the contrast group, the continuous lighting group and the
interstitial lighting group. The initial oxygen content was measured with a homemade device before the treatment. To
examine the different effects, both the interstitial lighting and the continuous lighting have the same fluent rates
(30mW/cm2, 32.4J/ cm2). The continuous lighting lasted 18 minutes while the interstitial lighting lasted 36 minutes
with 1 second's idle time and 1 second's effective time of each pulse. The result shows that the volume of tumor
doubling duration in interstitial lighting group is longer in the condition of low initial oxygen content. Thus with low
initial oxygen content, the interstitial lighting is more effective than the continuous lighting during PDT.
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