The problems related to the development of a multielement immunosensor device with the prism type of excitation of a surface plasmon resonance in the Kretschmann configuration and with the scanning of the incidence angle of monochromatic light aimed at the reliable determination of the levels of three molecular markers of the system of hemostasis (fibrinogen, soluble fibrin, and D-dimer) are considered. We have analyzed the influence of a technology for the production of a gold coating, modification of its surface, and noise effects on the enhancement of sensitivity and stability of the operation of devices. A means of oriented immobilization of monoclonal antibodies on the surface of gold using a multilayer film of copper aminopentacyanoferrate is developed. For the model proteins of studied markers, the calibrating curves (maximum sensitivity of 0.5 μg/ml) are obtained, and the level of fibrinogen in blood plasma of donors is determined. A four-channel modification of the device with an application of a reference channel for comparing the elimination of the noise of temperature fluctuations has been constructed. This device allows one to execute the express-diagnostics of prethrombotic states and the monitoring of the therapy of diseases of the blood circulation system.
The method of modification of the surface structure of the systems thin metal film-thick lithium niobate substrate is proposed. The ion implantation as a part of the technology process must be carried out by Ar+ ions with optimal energies and dozes. Depending of the film material, structure changes may be different: from little bubbles for Ni film to large craters and holes in the system for Pd film. The surface structure of such systems was researched by electron microscopy and Atomic Force Microscopy. The X-ray investigations of implanted systems are carried out too. The distinctions in the structure of implanted and nonimplanted systems are found. The theoretical calculations of profiles of braking recoil atoms are carried out by Monte-Carlo method for the energies of Ar+ ions of 50, 100 and 150 keV. It is found that the greatest degree of an amorphyzation in such systems is observed on depth conforming to a maximum of distribution of recoil atoms. It is shown that the considerable changes of the structure of the researched systems do not result in sufficient changes of optical properties of these systems owing to an implantation. The implanted systems thin metal film-thick lithium niobate substrate is proposed for effective using in modern opto-electronic devices with improved optical characteristics.
The special technology of development of pyroelectric detectors on a base of the systems "thin Pd film -- thick lithium niobate substrate" is proposed. The processing of such system by Ar+ ions is proposed for improving some characteristics of material for pyroelectric detector. The optimal Pd film thicknesses as well as ions energies and doses were calculated by Monte-Carlo method for reaching appropriate sensitivity and response of pyroelectric detectors. Investigation of surface structure of the systems by electronic microscopy and AFM method has shown that structural changes of the researched materials depend on film's material and its properties. This result is confirmed by ellipsometric study of the systems. The optical properties of nonimplanted and implanted systems "thin Pd film -- thick lithium niobate substrate" are investigated in the wide spectral range (200 nm - 15 μm). It is shown that the reflectance of the implanted system is nonselective in the infrared. The adhesion and antidegradation stability of metal films on bulk lithium niobate increase after implantation. The selection criteria for finding of appropriate film materials for application in modern optoelectronic devices are proposed.
The optical properties (the reflectance and the absorption) of the systems thin metal film - thick lithium niobate substrate (with film thicknesses of 15, 20, 30 and 40 nm) implanted by Ar+ ions with energies of 50, 100 and 150 keV and doses of 1015 - 1016 cm-2 are investigated in the wide spectral range (λ = 0.2 - 15 μm). It is shown that ion implantation influence on the absorption and the reflectance of such systems. Intensive atoms intermixing on the interface “film - substrate” change the optical properties of such systems. Different materials result to different effects. The changes of surface structure of Ni and Mo film on lithium niobate substrate slowly influence on their optical properties. But Pd film on lithium niobate substrate result to independence of reflectance from wavelength in the wide spectral range with magnification of an adhesion of the film to the substrate. AFM investigations of such systems show changes of the surface structure of the samples after the implantation. The effective use of such materials for pyroelectric photodetectors is proposed. The characteristics of pyroelectric photodetectors on the base of the systems “thin metal (Ni, Mo, Pd) film - thick lithium niobate substrate” implanted by Ar+ ions were investigated and compared with similar photodetectors. Such photodetectors have high sensitivity, response, radiation stability, detectivity, large dynamic range. Their functional characteristics not worse that characteristics of similar photodetectors. Owing to high radiation stability (large adhesion of metal film to substrate) such metal film based pyroelectric photodetectors can effectively use for registration of power laser radiation. The production process of metal film based pyroelectric photodetectors implanted by Ar+ ions is also proposed.
The pyroelectric detectors on the basis of systems: thin nickel film--thick lithium niobate substrate, thin molybdenum film--thick lithium niobate substrate and thin titanium film--thick lithium niobate substrate implanted by argon ions as sensitive elements were designed. The optical constants of such systems with film thicknesses of d=15, 20, 30, and 40 nm in the wide spectral range were measured. It is shown that the reflectance of the system thin nickel film--lithium niobate increases and the reflectance of the systems thin molybdenum film--thick lithium niobate substrate and thin titanium film--thick lithium niobate substate decreases owing to the implantation. The influence of ion implantation on the surface structure of such systems is studied by electron microscopy. The optical characteristics and the functional parameters of pyroelectric detectors such as spectral sensitivity, radiation stabilty are researched. The number of advantages of such pyroelectric detectors among other detectors of similar type is found.
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