KEYWORDS: Photodynamic therapy, Image segmentation, Projection systems, 3D modeling, 3D acquisition, 3D image processing, Dermatology, Light sources, 3D scanning, Cameras
Light dosimetry is an important parameter that affects the efficacy of photodynamic therapy (PDT). However, the irregular morphologies of lesions complicate lesion segmentation and light irradiance adjustment. Therefore, this study developed an illumination demo system comprising a camera, a digital projector, and a computing unit to solve these problems. A three-dimensional model of a lesion was reconstructed using the developed system. Hierarchical segmentation was achieved with the superpixel algorithm. The expected light dosimetry on the targeted lesion was achieved with the proposed illumination procedure. Accurate control and optimization of light delivery can improve the efficacy of PDT.
A photonic crystal fiber (PCF) with high nonlinearity and flattened dispersion is designed. The structure of PCF is in a
hexagon lattice. The larger air holes in the outer rings are used to confine the light field into the core region to enhance
the nonlinearity, and the flattened dispersion can be achieved by adjusting the diameters of six smaller air holes in the
first ring. By optimizing the sizes of the smaller and larger holes, the PCF can achieve high nonlinearity of 19 W-1km-1 and low dispersion of 80.96 ps/(nm·km) with the fluctuation dispersion range of 8.49 ps/(nm·km) within the wavelength range of 1400 to 1800 nm. The PCF designed can find important applications in effectively realizing Raman soliton
self-frequency shift and generating supercontinuum.
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