Mr. Yiqiang Zhu Profile

Yiqiang Zhu

at Univ. of Tsukuba

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Author

Publications (7)

Proceedings Article | 13 March 2024 Poster

Multiple scattering suppression for in vivo OCT measurement by B-scan-wise-multi-focus averaging method

Yiqiang Zhu, Lida Zhu, Shuichi Makita, Yiheng Lim, Yu Guo, Yoshiaki Yasuno

Proceedings Volume PC12830, PC1283013 (2024) https://doi.org/10.1117/12.3003699

KEYWORDS: Optical coherence tomography, In vivo imaging, Multiple scattering, Signal processing, Tunable filters, Tissues, Statistical analysis, Signal intensity, Scattering, Image resolution

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Proceedings Article | 13 March 2024 Presentation

In-vivo dynamic and multi-contrast imaging of human skin by motion-suppressed dynamic optical coherence tomography

Yu Guo, Rion Morishita, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Yiqiang Zhu, Yoshiaki Yasuno

Proceedings Volume 12816, 1281602 (2024) https://doi.org/10.1117/12.3001667

KEYWORDS: Optical coherence tomography, In vivo imaging, Skin, Biological samples, Visualization, Visual analytics, Tissues, Statistical analysis, Raster graphics, Mode conditioning cables

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Proceedings Article | 13 March 2024 Presentation + Paper

In vivo dynamic optical coherence tomography with hardware- and software-based motion correction

Yu Guo, Rion Morishita, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Yiqiang Zhu, Yoshiaki Yasuno

Proceedings Volume 12830, 128300Y (2024) https://doi.org/10.1117/12.3005623

KEYWORDS: Optical coherence tomography, In vivo imaging, Skin, Biological imaging, Tissues, Biological samples, Angiography

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Proceedings Article | 11 August 2023 Paper

Label-free intra-tissue activity imaging of alveolar organoid with three-dimensional dynamic optical coherence tomography

Rion Morishita, Pradipta Mukherjee, Ibrahim Abd El-Sadek, Toshio Suzuki, Antonia Lichtenegger, YiHeng Lim, Yiqiang Zhu, Shuichi Makita, Yuki Yamamoto, Tetsuharu Nagamoto, Yoshiaki Yasuno

Proceedings Volume 12632, 126321C (2023) https://doi.org/10.1117/12.2670861

KEYWORDS: Optical coherence tomography, 3D image processing, 3D modeling, Visualization, Tissues, Stem cells, Scattering, Medical research, Light sources, In vitro testing

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Proceedings Article | 9 March 2023 Presentation

Low- and high-resolution volumetric dynamic optical coherence tomography of in vitro cell cultures

Rion Morishita, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Tomoko Mori, Suzuki Toshio, Antonia Lichtengger, Lim Yi Heng, Zhu Yiqiang, Shuichi Makita, Yuki Yamamoto, Tetsuharu Nagamoto, Satoshi Matsusaka, Yoshiaki Yasuno

Proceedings Volume PC12367, PC123671D (2023) https://doi.org/10.1117/12.2652167

KEYWORDS: Optical coherence tomography, In vitro testing, 3D modeling, Visualization, Tissues, Stereoscopy, Medical research, Lung, Drug development, Cancer

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Proceedings Article | 8 March 2023 Poster + Paper

B-scan-wise multi-focus averaging method to suppress multiple scattering signal

Yiqiang Zhu, Lida Zhu, Shuichi Makita, Yiheng Lim, Yoshiaki Yasuno

Proceedings Volume 12367, 1236713 (2023) https://doi.org/10.1117/12.2652555

KEYWORDS: Optical coherence tomography, Scattering, Multiple scattering, Glasses, Particles, Tissues, In vivo imaging, Image acquisition, Computation time, 3D acquisition

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Proceedings Article | 8 March 2023 Presentation + Paper

Multiple scattering suppression by multi-focus averaging in Jones-matrix optical coherence tomography

Lida Zhu, Shuichi Makita, Yiheng Lim, Junya Tamaoki, Yiqiang Zhu, Makoto Kobayashi, Yoshiaki Yasuno

Proceedings Volume 12367, 123670E (2023) https://doi.org/10.1117/12.2652183

KEYWORDS: Optical coherence tomography, Scattering, Biological samples, Polarization, Multiple scattering, Modulation, Tissues

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Optical coherence tomography (OCT) has been utilized to investigate the optical properties of tissue in animal model studies. Polarization sensitive OCT (PS-OCT) is one of the functional extensions of OCT, which provides additional contrasts such as birefringence and degree-of-polarization uniformity (DOPU). It enables multi-contrast imaging for discrimination of tissue properties in biological samples. However, biological samples often exhibit multiple scattering (MS). It severely hampers the penetration depth and degrades the optical property measurement in deep regions for both OCT and PS-OCT. In a recently presented work, it was found that all of the scattering OCT value, birefringence value, and DOPU value were altered if they were measured at the deep region. This alteration is suspected to be artifacts caused by MS. So far, various methods have been proposed to tackle the MS issue. One is averaging several images with decorrelated MS signals. The decorrelation of MS signals was realized by wavefront shaping with complex devices such as spatial light modulators or deformable mirrors. However, these optics increase the cost and system complexity, and the wavefront shaping is still challenging. Simple hardware, such as multimode fiber, was only demonstrated in full-field OCT. In this work, we present a method termed as “multi-focus averaging” (MFA) to suppress the MS effect and improve the image contrast in deep regions of scattering samples. It uses focus modulation by a tunable lens to decorrelate MS signals among multiple acquisitions, and computational refocusing is used to cancel the different defocus during focus modulation. The refocused OCT signals are averaged in complex to reduce MS signals. It is demonstrated in standard OCT scheme, and a scattering phantom and a post-mortem zebrafish are used to validate the intensity contrast improvement. Results show that MFA images can provide better intensity contrast than standard complex averaging in scattering samples. In addition, we further adapt this method to PS-OCT to suppress the MS and to improve the accuracy of polarization sensitive measurement. We found MFA mitigated low-DOPU artifact in polarization sensitive measurement.

Showing 5 of 7 publications

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