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Development of a nanoscale heterostructured glucose sensor using modified microfabrication processes

[+] Author Affiliations
Devesh C. Deshpande

University of Arkansas, Innovative Nano/Bio Devices and Systems Laboratory, Department of Electrical Engineering, 700 Research Center Boulevard, Fayetteville, Arkansas 72701

Hargsoon Yoon

University of Arkansas, Innovative Nano/Bio Devices and Systems Laboratory, Department of Electrical Engineering, 700 Research Center Boulevard, Fayetteville, Arkansas 72701

Aung M. Khaing

University of Arkansas, Department of Biomedical Engineering, 203 Engineering Hall, Fayetteville, Arkansas 72701

Vijay K. Varadan

University of Arkansas, Innovative Nano/Bio Devices and Systems Laboratory, Department of Electrical Engineering, 700 Research Center Boulevard, Fayetteville, Arkansas 72701 and University of Arkansas, Department of Biomedical Engineering, 203 Engineering Hall, Fayetteville, Arkansas 72701 and University of Arkansas for Medical Sciences, Department of Neurosurgery, College of Medicine, 4301 W. Markham Street, Little Rock, Arkanas 72205

J. Micro/Nanolith. MEMS MOEMS. 7(2), 023005 (May 02, 2008). doi:10.1117/1.2911639
History: Received September 16, 2007; Revised November 28, 2007; Accepted December 28, 2007; Published May 02, 2008
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We discuss the development of a novel amperometric sensor to detect glucose concentrations in solution. Inorganic, vertically aligned nanowire arrays were employed as the sensing electrode in place of planar electrodes to utilize the unique properties of nanostructures, resulting in enhanced sensing signal from a smaller area. Heterostructured gold/platinum nanowires were used so that the dual functions of the nanoelectrodes for covalent immobilization of glucose oxidase and enhanced oxidation of hydrogen peroxide can be achieved using modified microfabrication methods. Two different enzyme immobilization methods—using self-assembled monolayers of alkanethiols and a porous conducting polypyrrole matrix—were investigated as methods for functionalizing the electrodes. Glucose sensing results were compared for planar and nanowire electrodes and the heterostructured nanowire electrodes. The results indicate that the unique structure of the sensing electrode delivers superior sensing performance from a smaller geometric area of electrodes, thus enabling further miniaturization of the sensor.

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© 2008 Society of Photo-Optical Instrumentation Engineers

Citation

Devesh C. Deshpande ; Hargsoon Yoon ; Aung M. Khaing and Vijay K. Varadan
"Development of a nanoscale heterostructured glucose sensor using modified microfabrication processes", J. Micro/Nanolith. MEMS MOEMS. 7(2), 023005 (May 02, 2008). ; http://dx.doi.org/10.1117/1.2911639


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