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Sensitivity improvement of a miniaturized label-free electrochemical impedance biosensor by electrode edge effect

[+] Author Affiliations
Yi-Ching Kuo

National Taiwan University, Engineering Science and Ocean Engineering, Taipei 10617, Taiwan

Ching-Sung Chen

National Taiwan University, Institute of Applied Mechanics, Taipei 10617, Taiwan

Ku-Ning Chang

National Taiwan University, Institute of Applied Mechanics, Taipei 10617, Taiwan

Chih-Ting Lin

National Taiwan University, Graduate Institute of Electronics Engineering, Taipei 10617, Taiwan

Chih-Kung Lee

National Taiwan University, Engineering Science and Ocean Engineering, Taipei 10617, Taiwan

National Taiwan University, Institute of Applied Mechanics, Taipei 10617, Taiwan

Research Center for Applied Sciences, Academic Sinica, Nankang, Taipei 11529, Taiwan

J. Micro/Nanolith. MEMS MOEMS. 13(3), 033019 (Sep 26, 2014). doi:10.1117/1.JMM.13.3.033019
History: Received April 16, 2014; Revised August 28, 2014; Accepted August 29, 2014
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Abstract.  Point-of-care (PoC) biosensors continue to gain popularity because of the desire to improve cost performance in today’s health care industry. As cardiovascular disease (CVD) remains one of the top three leading causes of death in Asia, a tool that can help to detect CVDs is highly sought after. We present a high-sensitivity PoC biosensor that can be used to detect CVD biomarkers. To meet the requirements of a PoC biosensor, we adopted electrochemical methods as the basis of the detection. A more stable three-electrode configuration was miniaturized and put onto a biochip. To improve the detection sensitivity associated with the reduced size in the biochip, computer simulation was used to investigate several potential effective possibilities. We found that the electrolyte current density on the edge near the working electrode (WE) and counter electrode (CE) was higher. This was verified using an atomic force microscope to measure the surface potential. We then experimented with the configuration by lengthening the edge of the WE and CE without changing the area of the WE and CE and maintained the gap between the two electrodes. We found improved measurement efficiency with our newly developed biochip.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Yi-Ching Kuo ; Ching-Sung Chen ; Ku-Ning Chang ; Chih-Ting Lin and Chih-Kung Lee
"Sensitivity improvement of a miniaturized label-free electrochemical impedance biosensor by electrode edge effect", J. Micro/Nanolith. MEMS MOEMS. 13(3), 033019 (Sep 26, 2014). ; http://dx.doi.org/10.1117/1.JMM.13.3.033019


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