Ms. Arushi Jain Profile

Arushi Jain

at Univ of Bern

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Proceedings Article | 13 March 2019 Presentation

Polarimetric imaging of the light backscattered from multiply scattering nanofibrous PVDFhfp scaffolds (Conference Presentation)

Arushi Jain, Anjani Maurya, Alex Dommann, Antonia Neels, Martin Frenz, H. Günhan Akarçay

Proceedings Volume 10890, 108900E (2019) https://doi.org/10.1117/12.2507399

KEYWORDS: Light scattering, Scattering, Polarimetry, Tissue optics, Backscatter, Laser scattering, Nanofibers, Polarization, Optical fibers, Microscopes

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Understanding light propagation in fibrous tissue plays a fundamental role in the development of novel and minimally invasive diagnosis techniques. For this purpose, we have developed a polarimetric microscope that operates in the backscattering geometry. Our apparatus has been thoroughly calibrated and verified with experiments and Monte Carlo simulations on well characterized colloidal suspensions. In this study, we have investigated the feasibility of retrieving structural information on multiply scattering, fibrous electrospun scaffolds fabricated of Poly(vinylidene fluoride-co-hexafluoropropylene) (PVDFhfp) nanofibers having diameters ranging from 500 to 1000 nm. These nanofibers display various degrees of structural alignment and the structural anisotropy manifests itself in optical birefringence. We probed these scaffolds with a focused near-infrared light beam at three pairs of cross-polarized states and recorded images of the Stokes vector elements of the light backscattered at the surfaces of the scaffolds. Our results demonstrate that it is possible to structurally differentiate the scaffolds by analyzing the spatial variations of the Stokes vectors/polarization ellipses as a function of the polarization state of the probing beam. Visualizing the rate of retardance induced by the birefringent fibers together with the distribution of the degree of polarization unveils the orientation of these fibers and their respective degree of organization, which was compared to results obtained by small angle x-ray scattering (SAXS). This study contributes to a better understanding of the interaction of the light with multiply scattering fibrous matter such as tissue, which is particularly challenging in the backscattering geometry but fundamental to make the diagnosis of cancer possible.

Proceedings Article | 4 March 2019 Presentation

Towards the analytical modeling of backscattering polarimetric patterns recorded from multiply scattering systems (Conference Presentation)

Hidayet Günhan Akarçay, Manes Hornung, Arushi Jain, Martin Frenz

Proceedings Volume 10883, 108830J (2019) https://doi.org/10.1117/12.2509366

KEYWORDS: Polarimetry, Light scattering, Scattering, Backscatter, Systems modeling, Biological research, Imaging systems, Tissue optics, Diagnostics, Microscopes

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A better understanding of the interaction of polarized light with biological tissue can lead to the development of valuable and minimally invasive diagnostics tools. Yet, this can be a challenging undertaking in the presence of multiply scattering. We have built a polarimetric microscope to probe multiply scattering systems In the backscattering geometry. Our apparatus has been calibrated and validated by comparing measurements to the outcomes of Monte Carlo simulations. We have recorded the spatially distributed Stokes vectors of the light backscattered from various standard samples (colloidal suspensions with varying sphere sizes, birefringent cellophane tape, etc.). To understand the behavior of these samples, we have developed: (i) a methodology that makes explicit the dependence of the polarimetric properties on the polarization state of the probing light beam; (ii) and a forward analytical model that is based on the coherency matrix and generates backscattered polarimetric patterns. Our findings demonstrate that additionally to ‘classical’ polarimetric properties (diattenuation, retardance, and depolarization), the helicity flip induced by the samples should also be included into the parametrization. This allows not only to reproduce the measurements, but also to discriminate between the different samples. Identifying the birefringent properties and structural anisotropy of the probed samples is made possible. This study is in line with research aimed at re-evaluating the polarimetric properties of multiply scattering systems and constitutes the groundwork to the accompanying contribution entitled «Polarimetric imaging of the light backscattered from multiply scattering nanofibrous PVDFhfp scaffolds».

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