Potential application of mesenchymal stem cells exosomes for drug loading

Xiangyu Gao

doi:10.1117/12.2669976

24 March 2023 Potential application of mesenchymal stem cells exosomes for drug loading

Xiangyu Gao

Author Affiliations +

Proceedings Volume 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022); 126116B (2023) https://doi.org/10.1117/12.2669976
Event: International Conference on Biological Engineering and Medical Science (ICBioMed2022), 2022, Oxford, United Kingdom

Abstract

In modern therapeutic medicine, nano-drug delivery research has drawn more and more attention. Researchers are conducted on cellular drug delivery, trying to deliver drugs by a series of cells secreted from the body, and engineer them to be targeted. Among them, mesenchymal stem cells (MSCs) and exosomes secreted by MSCs showed extremely important value. MSCs are adult stem cells isolated from different types of tissues that can differentiate into other types of cells. While Exosomes is one of the three extracellular vesicles secreted normally by different kinds of cells. Exosomes secreted by MSCs have special lipid structure and biological characteristics which make them of great potential in the future engineering of cell drug delivery. This paper starts with the medical value of MSCs, analyzes the future potential of cell therapy via exosomes secreted by MSCs and introduces the engineering methods of drug delivery by exosomes and targeted modification of exosomes. Nevertheless, so far there are still limitations in exosome drug loading, such as how to produce and modify exosomes in large quantities, how to carry out a series of preservation work after exosome production, and mass culture of MSCs. These are the questions that future scientists need to focus on.

Citation Download Citation

Xiangyu Gao "Potential application of mesenchymal stem cells exosomes for drug loading", Proc. SPIE 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022), 126116B (24 March 2023); https://doi.org/10.1117/12.2669976

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