Discovery radiomics via evolutionary deep radiomic sequencer discovery for pathologically proven lung cancer detection

Mohammad Javad Shafiee; Audrey G. Chung; Farzad Khalvati; Masoom A. Haider; Alexander Wong

doi:10.1117/1.JMI.4.4.041305

6 October 2017 Discovery radiomics via evolutionary deep radiomic sequencer discovery for pathologically proven lung cancer detection

Mohammad Javad Shafiee, Audrey G. Chung, Farzad Khalvati, Masoom A. Haider, Alexander Wong

Author Affiliations +

Journal of Medical Imaging, Vol. 4, Issue 4, 041305 (October 2017). https://doi.org/10.1117/1.JMI.4.4.041305

Abstract

While lung cancer is the second most diagnosed form of cancer in men and women, a sufficiently early diagnosis can be pivotal in patient survival rates. Imaging-based, or radiomics-driven, detection methods have been developed to aid diagnosticians, but largely rely on hand-crafted features that may not fully encapsulate the differences between cancerous and healthy tissue. Recently, the concept of discovery radiomics was introduced, where custom abstract features are discovered from readily available imaging data. We propose an evolutionary deep radiomic sequencer discovery approach based on evolutionary deep intelligence. Motivated by patient privacy concerns and the idea of operational artificial intelligence, the evolutionary deep radiomic sequencer discovery approach organically evolves increasingly more efficient deep radiomic sequencers that produce significantly more compact yet similarly descriptive radiomic sequences over multiple generations. As a result, this framework improves operational efficiency and enables diagnosis to be run locally at the radiologist’s computer while maintaining detection accuracy. We evaluated the evolved deep radiomic sequencer (EDRS) discovered via the proposed evolutionary deep radiomic sequencer discovery framework against state-of-the-art radiomics-driven and discovery radiomics methods using clinical lung CT data with pathologically proven diagnostic data from the LIDC-IDRI dataset. The EDRS shows improved sensitivity (93.42%), specificity (82.39%), and diagnostic accuracy (88.78%) relative to previous radiomics approaches.

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Mohammad Javad Shafiee, Audrey G. Chung, Farzad Khalvati, Masoom A. Haider, and Alexander Wong "Discovery radiomics via evolutionary deep radiomic sequencer discovery for pathologically proven lung cancer detection," Journal of Medical Imaging 4(4), 041305 (6 October 2017). https://doi.org/10.1117/1.JMI.4.4.041305

Received: 7 May 2017; Accepted: 14 September 2017; Published: 6 October 2017

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