Videocapillaroscopy (VCS) and laser Doppler flowmetry (LDF) are non-invasive methods for evaluating microcirculation parameters. The VCS method is based on a high-speed video recording of capillaries in the nailfold. The recorded video frames are processed using a specialized algorithm to determine the red blood cells velocity. The LDF technique is based on the analysis of the Doppler shift of back-scattered laser radiation from moving red blood cells. In this work, simultaneous measurements of VCS and LDF have been performed in healthy volunteers and rheumatic patient. The study was conducted using a cold pressor test. Changes were recorded in response to cold exposure in rheumatic diseases.
Advanced processing of high-speed video-capillaroscopy data revealed that
erythrocytes speed follows variations of arterial blood pressure, whereas intensity of light returned
from a single capillary is almost unmodulated at the heartbeat frequency.
A multi-view scanning method is suggested to assess a complicated surface relief by white light interferometer.
Peculiarities of the method are demonstrated on a special object in the form of quadrangular pyramid cavity, which is
formed at measurement of micro-hardness of materials using a hardness gauge. An algorithm of the joint processing of
multi-view scanning results is developed that allows recovering correct relief values. Laser ablation craters were studied
experimentally, and their relief was recovered using the developed method. It is shown that the multi-view scanning
reduces ambiguity when determining the local depth of the laser ablation craters micro relief. Results of experimental
studies of the multi-view scanning method and data processing algorithm are presented.
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