Prof. Avraham Mayevsky Profile

Prof. Avraham Mayevsky

at Bar-Ilan Univ

SPIE Involvement:

Author

Publications (27)

SPIE Journal Paper | 27 January 2014 Open Access

Preclinical evidence of mitochondrial nicotinamide adenine dinucleotide as an effective alarm parameter under hypoxia

Hua Shi, Nannan Sun, Avraham Mayevsky, Zhihong Zhang, Qingming Luo

JBO, Vol. 19, Issue 01, 017005, (January 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.1.017005

KEYWORDS: Hypoxia, Electrocardiography, Reflectivity, Oxygen, Tissues, Luminescence, Brain, Cerebral blood flow, Arteries, Nitrogen

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SPIE Journal Paper | 1 June 2011 Open Access

Mitochondrial function and tissue vitality: bench-to-bedside real-time optical monitoring system

Avraham Mayevsky, Eliyahu Pewzner, Assaf Deutsch, Raphael Walden, Eitan Heldenberg, Jacob Lavee, Salis Tager, Erez Kachel, Ehud Raanani, Sergey Preisman, Violete Glauber, Eran Segal

JBO, Vol. 16, Issue 06, 067004, (June 2011) https://doi.org/10.1117/12.10.1117/1.3585674

KEYWORDS: Tissues, Tissue optics, Oxygen, Blood circulation, Blood, Surgery, In vivo imaging, Luminescence, Brain, Reflectivity

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Proceedings Article | 6 March 2009 Paper

The role of nitric oxide in the ischemic brain evaluated by spectroscopic monitoring of mitochondrial NADH, microcirculatory blood flow, and HbO2

Efrat Eibeshitz, Efrat Barbiro-Michaely, Avraham Mayevsky

Proceedings Volume 7280, 72801J (2009) https://doi.org/10.1117/12.822132

KEYWORDS: Brain, Ischemia, Reflectivity, Oxygen, Blood circulation, Blood, NOx, Arteries, Doppler effect, Tissue optics

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Proceedings Article | 6 March 2009 Paper

Evaluation of mitochondrial NADH and brain functions during retraction using a multiparametric monitoring system

Efrat Barbiro-Michaely, Hana Arnon, Avraham Mayevsky

Proceedings Volume 7280, 72801I (2009) https://doi.org/10.1117/12.821773

KEYWORDS: Brain, Tissues, Luminescence, Electrodes, Injuries, Reflectivity, Optical fibers, Ischemia, Blood circulation, Doppler effect

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Proceedings Article | 6 March 2009 Paper

Classification of tissue pathological state using optical multiparametric monitoring approach

Hofit Kutai-Asis, Ido Kanter, Efrat Barbiro-Michaely, Avraham Mayevsky

Proceedings Volume 7280, 72801K (2009) https://doi.org/10.1117/12.822134

KEYWORDS: Brain, Tissues, Blood circulation, Tissue optics, Oxygen, Doppler effect, Fluorometers, Ischemia, Arteries, Reflectometry

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Proceedings Article | 5 March 2009 Paper

Mitochondrial activity and brain functions during cortical depolarization

Avraham Mayevsky, Judith Sonn

Proceedings Volume 7280, 728002 (2009) https://doi.org/10.1117/12.823909

KEYWORDS: Brain, Oxygen, Tissues, Ischemia, Electrodes, Ions, Hemodynamics, Blood, Reflectivity, Hypoxia

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Proceedings Article | 25 February 2009 Paper

The involvement of nitric oxide in the hemodynamic and metabolic activities of the brain and small intestine

M. Tolmasov, E. Barbiro-Michaely, A. Mayevsky

Proceedings Volume 7169, 716906 (2009) https://doi.org/10.1117/12.808720

KEYWORDS: Brain, Intestine, Blood circulation, Brain mapping, Optical fibers, NOx, Luminescence, Hemodynamics, Oxygen, Doppler effect

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Proceedings Article | 24 February 2009 Paper

Mitochondrial function and cerebral blood flow responses under unilateral carotid occlusion in rats

Amir Livnat, Efrat Barbiro-Michaely, Avraham Mayevsaky

Proceedings Volume 7180, 718003 (2009) https://doi.org/10.1117/12.808734

KEYWORDS: Brain, Arteries, Reflectivity, Blood, Oxygen, Ischemia, Cerebral blood flow, Tissues, Hemodynamics, Doppler effect

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Proceedings Article | 21 February 2009 Paper

Evaluation of the CritiView in pig model of abdominal aortic occlusion and graded hemorrhage

A. Mayevsky, S. Preisman, P. Willenz, D. Castel, A. Perel, D. Givony, N. Dekel, L. Oren, E. Pewzner

Proceedings Volume 7173, 71730L (2009) https://doi.org/10.1117/12.808690

KEYWORDS: Blood, Tissues, Oxygen, Blood circulation, Tissue optics, Bladder, Hemodynamics, Reflectivity, Animal model studies, Intestine

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Proceedings Article | 12 February 2008 Paper

Effects of compression injury on brain mitochondrial and tissue viability evaluated by a multiparametric monitoring system

Efrat Barbiro-Michaely, Galit Bachbut, Avraham Mayevsky

Proceedings Volume 6848, 68480M (2008) https://doi.org/10.1117/12.761068

KEYWORDS: Tissues, Brain, Injuries, Reflectivity, Cerebral cortex, Electrodes, Cerebral blood flow, Blood circulation, Hemodynamics, Optical fibers

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Proceedings Article | 8 February 2008 Paper

Mitochondrial dysfunction: bench-to-bedside optical monitoring of tissue vitality

Avraham Mayevsky, Nava Dekel, Levi Oren, Assaf Deutsch, Eliyahu Pewzner

Proceedings Volume 6853, 68531B (2008) https://doi.org/10.1117/12.761118

KEYWORDS: Tissue optics, Tissues, Luminescence, Oxygen, Surgery, Blood circulation, Ischemia, Blood, Digital signal processing, In vivo imaging

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In normal cell the mitochondria are the major source of energy for cellular functions. They serve as biosensors for oxidative stress and involved also in termination of cell function by apoptosis. The involvement of mitochondria in pathological states such as neurodegenerative diseases, sepsis, stroke and cancer are well documented. The involvement of mitochondrial respiration and function in cancer development, proliferation and possible therapy were initiated 75 years ago by Otto Warburg. Monitoring of NADH fluorescence in vivo as an intracellular oxygen indicator was established in the 1950-1970 by Britton Chance and collaborators. In the last 20 years we developed and used a multiparametric monitoring system enabling real time assessment of mitochondria NADH, microcirculatory blood flow and volume as well as HbO₂ oxygenation. In order to use this technology in clinical practice the commercial developed device-the "CritiView" was tested in animal models as well as in patients hospitalized in the critical care departments. In patients we tested the viability of the urethral wall (a less-vital tissue) by a 3 way Foley urinary catheter that contains the optical probe. The catheter was introduced to patients underwent open heart by-pass surgery or abdominal aorta aneurysm (AAA) operations. The monitoring started immediately after the insertion of the catheter to the patient and was stopped when the patient was discharged from the operation room. The results show that monitoring of the vitality of the Urethral wall provides information in correlation to the surgical procedure performed. In the AAA patients the occlusion of the aorta led to severe ischemia developed in the urethral wall and recovery of signals were recorded after the reopening of the aorta. In patients under went heart bypass surgery the urethra vitality was decreased dramatically during the operation and recovery was noted in most patients after the discharge of the patient from the operation room.

Proceedings Article | 13 February 2007 Paper

Simultaneously multiparametric spectroscopic monitoring of tissue viability in the brain and small intestine

Michael Tolmasov, Efrat Barbiro-Michaely, Avraham Mayevsky

Proceedings Volume 6434, 64341N (2007) https://doi.org/10.1117/12.699445

KEYWORDS: Brain, Intestine, Tissues, Oxygen, Hypoxia, Blood circulation, Optical fibers, Tissue optics, Reflectivity, Brain mapping

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Proceedings Article | 6 February 2007 Paper

Optical assessment of intravascular and intracellular parameters related to tissue viability

Avraham Mayevsky, Efrat Sherman, Meir Cohen-Kashi, Nava Dekel, Eliyahu Pewzner

Proceedings Volume 6430, 64300Z (2007) https://doi.org/10.1117/12.699778

KEYWORDS: Tissue optics, Blood, Tissues, Reflectivity, Brain, Ischemia, Oximeters, Laser tissue interaction, Blood circulation, Oxygen

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Proceedings Article | 15 February 2006 Paper

Fiber optic based multiparametric spectroscopy in vivo: toward a new quantitative tissue vitality index

Hofit Kutai-Asis, Efrat Barbiro-Michaely, Assaf Deutsch, Avraham Mayevsky

Proceedings Volume 6083, 608310 (2006) https://doi.org/10.1117/12.675755

KEYWORDS: Tissues, Brain, Blood circulation, Oxygen, Ischemia, Arteries, In vivo imaging, Blood, Tissue optics, Doppler effect

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Proceedings Article | 15 February 2006 Paper

The CritiView: a new fiber optic based optical device for the assessment of tissue vitality

Avraham Mayevsky, Yoram Blum, Nava Dekel, Assaf Deutsch, Rafael Halfon, Shlomi Kremer, Eliyahu Pewzner, Efrat Sherman, Ofer Barnea

Proceedings Volume 6083, 60830Z (2006) https://doi.org/10.1117/12.675745

KEYWORDS: Tissues, Tissue optics, Light sources, Brain, Reflectivity, Fiber optics, Ischemia, Luminescence, Blood, Laser tissue interaction

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Proceedings Article | 1 April 2005 Paper

A new biomedical device for in vivo multiparametric evaluation of tissue vitality in critical care medicine

Avraham Mayevsky, Assaf Deutsch, Nava Dekel, Eliyahu Pevzner, Alex Jaronkin

Proceedings Volume 5692, (2005) https://doi.org/10.1117/12.587584

KEYWORDS: Tissues, Blood, Brain, Luminescence, Reflectivity, Tissue optics, In vivo imaging, Blood circulation, Oxygen, Ischemia

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SPIE Journal Paper | 1 September 2004 Open Access

Tissue spectroscope: a novel in vivo approach to real time monitoring of tissue vitality

Avraham Mayevsky, Tamar Manor, Eliyahu Pevzner, Assaf Deutsch, Revital Etziony, Nava Dekel, Alex Jaronkin

JBO, Vol. 9, Issue 05, (September 2004) https://doi.org/10.1117/12.10.1117/1.1780543

KEYWORDS: Tissues, In vivo imaging, Tissue optics, Brain, Oxygen, Luminescence, Blood, Blood circulation, Doppler effect, Optical fibers

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Proceedings Article | 13 July 2004 Paper

Brain physiological state evaluated by real-time multiparametric tissue spectroscopy in vivo

Avraham Mayevsky, Efrat Barbiro-Michaely, Hofit Kutai-Asis, Assaf Deutsch, Alex Jaronkin

Proceedings Volume 5326, (2004) https://doi.org/10.1117/12.528599

KEYWORDS: Brain, Reflectivity, Ischemia, Blood, In vivo imaging, Cerebral blood flow, Tissue optics, Luminescence, Tissues, Oxygen

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Proceedings Article | 10 June 2004 Paper

Real-time evaluation of tissue vitality by monitoring of microcirculatory blood flow, HbO2, and mitochondrial NADH redox state

Assaf Deutsch, Eliyahu Pevzner, Alex Jaronkin, Avraham Mayevsky

Proceedings Volume 5317, (2004) https://doi.org/10.1117/12.528601

KEYWORDS: Tissues, Tissue optics, Reflectivity, Light emitting diodes, Light sources, Blood circulation, Oxygen, Ischemia, Luminescence, Blood

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Proceedings Article | 29 July 2003 Paper

In vivo simultaneous cortical and intracortical monitoring of cerebral blood flow and mitochondrial redox state in experimental animals

E. Barbiro-Michaely, T. Zuckerman, N. Zarchin, S. Rinkevich, N. Knoller, M. Hadani, A. Mayevsky

Proceedings Volume 4955, (2003) https://doi.org/10.1117/12.476799

KEYWORDS: Brain, Animal model studies, Arteries, Ischemia, Tissues, Cerebral blood flow, In vivo imaging, Oxygen, Reflectivity, Electrodes

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Proceedings Article | 22 July 2003 Paper

Real-time multiparametric spectroscopy as a practical tool for evaluation of tissue vitality in vivo

Eliyahu Pevzner, Assaf Deutsch, Tamar Manor, Nava Dekel, Revital Etziony, Igor Derzy, Nisim Razon, Avraham Mayevsky

Proceedings Volume 4958, (2003) https://doi.org/10.1117/12.476121

KEYWORDS: Tissue optics, Semiconductor lasers, Tissues, Brain, Light sources, Sensors, Fiber optics, Ultraviolet radiation, Doppler effect, Luminescence

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Proceedings Article | 5 June 2002 Paper

Multiparametric monitoring of rat brain retraction

Andrew Kanner, Zvi Rappaport, Tamar Manor, Avraham Mayevsky

Proceedings Volume 4623, (2002) https://doi.org/10.1117/12.491257

KEYWORDS: Brain, Potassium, Tissues, Electrodes, Cerebral blood flow, Ischemia, Blood, Surgery, Tumors, Electroencephalography

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Proceedings Article | 26 March 2002 Paper

Real-time optical monitoring of tissue vitality in vivo

Avraham Mayevsky, Tamar Manor, Eliyahu Pevzner, Assaf Deutsch, Revital Etziony, Nava Dekel

Proceedings Volume 4616, (2002) https://doi.org/10.1117/12.463821

KEYWORDS: Tissue optics, Tissues, Brain, In vivo imaging, Blood circulation, Light sources, Optical fibers, Luminescence, In vitro testing, Spectroscopes

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Proceedings Article | 22 May 2001 Paper

Multiparametric monitoring of tissue vitality in clinical situations

Avraham Mayevsky, Tamar Manor, Sigal Meilin, Nisim Razon, George Ouknine, Eugene Ornstein

Proceedings Volume 4255, (2001) https://doi.org/10.1117/12.426742

KEYWORDS: Tissues, Brain, Blood circulation, Tissue optics, Electrodes, Ions, Kidney, Potassium, Cerebral blood flow, Doppler effect

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Proceedings Article | 4 May 2001 Paper

Optical monitoring of tissue viability using reflected spectroscopy in vivo

Avraham Mayevsky, Ari Kraut, Tamar Manor, Judith Sonn, Yehuda Zurovsky

Proceedings Volume 4241, (2001) https://doi.org/10.1117/12.431553

KEYWORDS: Tissues, Brain, Blood circulation, Tissue optics, Reflectance spectroscopy, Doppler effect, Ischemia, Heart, In vivo imaging, Liver

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Proceedings Article | 1 May 1991 Paper

Frequency-domain measurements of changes of optical pathlength during spreading depression in a rodent brain model

Michael Maris, Avraham Mayevsky, Eva Sevick, Britton Chance

Proceedings Volume 1431, (1991) https://doi.org/10.1117/12.44185

KEYWORDS: Brain, Hypoxia, Imaging spectroscopy, Ischemia, Phase modulation, Blood, Blood circulation, Time resolved spectroscopy, Tissue optics, Spectroscopy

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Proceedings Article | 1 May 1991 Paper

Fiber optic based multiprobe system for intraoperative monitoring of brain functions

Avraham Mayevsky, E. Flamm, William Pennie, Britton Chance

Proceedings Volume 1431, (1991) https://doi.org/10.1117/12.44201

KEYWORDS: Brain, Electrodes, Ions, Doppler effect, Ischemia, Arteries, Tissues, Imaging spectroscopy, Luminescence, Hypoxia

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Monitoring of brain functions during neurosurgical conditions have been made by various groups of investigators. Attempts were made to monitor EEG or evoked potentials, cerebral blood flow, mitochondrial redox state during various neurosurgical procedures. In order to monitor various functions of the brain we have developed a new multiprobe (MPA) assembly, based on fiber optic probes and ion selective electrodes, enabling the assessment of relative CBF, mitochondrial redox state (NADH fluorescence) and ion homeostasis in real-time, intraoperatively. The base features of the multiprobe assembly were described previously (A. Mayevsky, J. Appl. Physiol. 54, 740-748, 1983). The multiprobe holder (made of Delarin) contained a bundle of fibers transmitting light to and from the brain as well as 3 ion selective electrodes (K+%/, Ca(superscript 2+, Na+) combined with DC steady potential electrodes (Ag/AgCl). The common part of the light guide contained 2 groups of fibers. For the Laser Doppler flowmetry one input fiber and two output fibers were glued in a triangular shape and connected to the standard commercial plug of the Laser Doppler flowmeter. For the monitoring of NADH redox state 10 excitation and 10 emission fibers were randomly mixed between and around the fibers used for the Laser Doppler flowmetry. This configuration of the fibers enabled us to monitor CBF and NADH redox state from about the same tissue volume. The ion selective electrodes were connected to an Ag/AgCl electrode holders and the entire MPA was protected by a Plexiglass sleeve. Animal experiments were used for the verification of the methods and recording of typical responses to various pathological situations. The entire multiprobe assembly was sterilized by the standard gas sterilization routine and was checked for electrodes integrity and calibration inside the operation room 24 hours later. The MPA was located on the exposed human cortex using a micromanipulator and data collection started immediately after, using a micro computer based data acquisition system. After recording of baseline levels of CBF, NADH redox state and extracellular ion levels, the responses to CBF decrease (occlusions of a blood vessel) were recorded followed by the recovery period. A significant correlation between the CBF and NADH redox state changes was recorded. This approach enabled us to correlate this change in energy supply, to those of extracellular ion concentration. The preliminary results obtained suggest that the usage of the MPA in the operating room may have a significant contribution to the neurosurgeon as a routine diagnostic tool. It seems to us that a simplified MPA which will enable to monitor only the relative CBF, NADH redox state as well as extracellular K+ is more appropriate for future usage.

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