Although diffuse reflectance measurement has convenience in obtaining spectra from skin, it has extremely low light efficiency compared with other configurations as the skin has forward scattering characteristics. To increase the amount of photon illumination and enhance SNR, we suggest a honeycombed optical skin interface with multi-fibers based probe for the diffuse reflectance measurement of skin. Experimental results with human and swine skin measurements show the spectral noise of the skin spectra in the range of 13~16 µAU and the effective water path length in the range of 1.8~2.2 mm. With this honeycombed skin interface, 5~6 times enhanced spectral SNR can be obtained.
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