Ischemic cerebral edema (CE) is a major cause of death in patients with ischemic stroke. Detecting CE and local cerebral blood perfusion (LCBP) simultaneously may offer valuable insights for treating ischemic stroke (IS). In this work, a swept-source optical coherence tomography (SS-OCT) system was established to evaluate the photo-thrombosis ischemia mouse model for a long time. The progressive state of CE and LCBP was quantified and analyzed. Preliminary studies revealed that edema significantly affected LCBP with a clear spatial dependence, the edema area increased sharply when the LCBP dropped to around 60% of the initial value.
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