Prof. Jianming Tan Profile

Prof. Jianming Tan

at Fuzhou General Hospital of Nanjing Military Command

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Proceedings Article | 5 November 2018 Paper

OCT of living human kidney: case study

Yuhong Fang, Wei Gong, Junxia Li, Jianming Tan, Weijun Li, Yongzeng Li, Shusen Xie, Zheng Huang

Proceedings Volume 10816, 108161R (2018) https://doi.org/10.1117/12.2502655

KEYWORDS: Optical coherence tomography, Kidney, Image segmentation, 3D image processing, Transplantation, Image analysis, Distortion

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Optical coherence tomography (OCT) is a useful optical biopsy tool. Its potential in the evaluation of living kidney has been demonstrated. One of such applications is to predict the acute tubular necrosis (ATN) associated with kidney transplantation. The light dense and lucent regions seen in 2D OCT scanning are considered as a useful marker of the renal tubules. In this study, the OCT examination of living human kidney was carried out using a swept source (SS) OCT (SS-OCT) system. The light lucent regions in the cortex obtained on the OCT scan were defined as low signal cavities. The structure features of characteristic cavities in 2D and simulated 3D OCT images were quantitatively analyzed using Amira and Matlab programs. Although the imaging acquisition and real-time analysis were feasible for the examination of donor kidney before and after the transplantation, as the imaging acquisition was obtained under the hand-hold fashion, OCT images might become blurred and the tubules became hardly distinguishable from cortex background, especially for 3D images. In order to optimize the scanning parameters of the OCT imaging process, the influence of the jittering of the living kidney on the quality of OCT imaging and the distortion of the renal tubule structure were studied.

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