Sickle Cell Disease (SCD) is an inherited hemoglobin disorder associated with multiple organ damage caused by continuous inflammation and systemic vasculopathy. There is a need for comprehensive technologies that can characterize vascular hemodynamics at the bedside. Near-infrared spectroscopy (NIRS) techniques show promise as a non-invasive diagnostic tool for monitoring tissue hemodynamics. Subjects with SCD were recruited to undergo longitudinal optical measurements while participating in a long-term efficacy study of Mitapivat, a pyruvate kinase activator under clinical development. We demonstrate the sensitivity of multiple modalities to hemodynamic changes in patients that achieved a < 1g/dL increase in hemoglobin level.
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