Objective: Dual Heart Disease in Traditional Chinese Medicine (DHDTCM) is characterized by suboptimal heart function and depressive-like behaviors. Our hypothesis was that electro-acupuncture (EA) could enhance heart function and alleviate depression in this setting. Methods: Sixty SD rats were randomly divided into five groups: blank, model, EA, traditional Chinese medicine(TCM), and Western medicine(WM). The DHDTCM model was created via Chronic Unpredictable Mild Stress (CUMS) and isoproterenol injection. In the EA group, five points were alternately stimulated by EA. Different treatments were given for 21 days: sertraline in the WM group, an herbal formula in the CM group, and normal saline in the model group. Results: The model was successfully established. EA improved depressive-like behaviors in dual heart disease, as shown in tests. In the OFT, relevant indicators increased in the EA group. EA enhanced cardiac function, as indicated by changes in CD31 and the ECG ST segment. Levels of BDNF and NGF rose. EA regulated HIF-1α content in relevant parts. Conclusions: The results suggest that EA can enhance heart function and ease the depressive state in rats. It indicates that the therapeutic effect of EA on dual heart diseases might result from regulating HIF-1α.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.