We report a pioneer clinical study using triple-input polarization-sensitive optical coherence tomography (TRIPS-OCT) to assess sub-macular scleral birefringence in 60 children with myopia. Results showed a significant difference in scleral birefringence between high and low myopia groups. In addition, we observed a correlation between axial length and birefringence in the low myopia group. This suggests the potential of using sub-macular scleral birefringence as a biomarker for myopia progression. Despite a high exclusion ratio due to inadequate scleral visibility and other limitations, these findings warrant further large-scale studies.
We investigate the influence of the OCT system resolution on high-quality en face corneal endothelial cell images in vivo, to allow for quantitative analysis of cell density. We vary the lateral resolution of the ultrahigh-resolution (UHR) OCT system (centered at 850 nm) by using different objectives, and the axial resolution by windowing the source spectrum. We are able to obtain a high-quality en face corneal endothelial cell map in vivo using UHR OCT for the first time. Quantitative analysis result of cell density from in vivo en face corneal endothelial cell map agrees with previously reported data.
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