Retinal images technology such as optical coherence tomography (OCT), OCT-angiography (OCTA) and fluorescein angiography (FA) are an important for diagnosing eye diseases. As retinal imaging technology continues to evolve, standard test methods and optical phantoms for demonstrating image quality and performance also need to be developed and advanced. We used mixture solution of polydimethylsiloxzne (PDMS) and different titanium dioxide (TiO2) to develop a more realistic retinal phantom. The retinal phantom consists of two multilayer membranes, a base plate with retinal curvature, and three microfluidic channels. In addition, we developed retinal phantom for fluorescence imaging using micro-fluorescence beads. We could obtain OCT, OCTA, and fluorescence images.
Optical coherence tomography (OCT) is one of imaging technologies to diagnose ophthalmic diseases and to monitor progresses of treatments. Therefore, OCT and OCT-angiography (OCTA) have actively developed in the field of ophthalmology, and retinal phantoms for evaluation of performance of OCT and OCTA also have been studied. In this presentation, we will show methods and results of a retinal phantom that can evaluate the optical performance of OCT and OCTA. The retinal phantom not only mimicked superficial vascular networks more realistically, but also implemented retinal layers with curvature. It consists of two microfluidic channels corresponding to superficial and deep retinal vessels, two multi-layered thin films, and base plate with retinal curvature. Each was attached with oxygen plasma for 1-min and fluorinated ethylene propylene (FEP) tubes was connected to the inlet and outlet holes. We could obtain cross-sectional OCT images and en-face OCTA images using lab-made OCT system.
The retinal imaging system, such as optical coherence tomography (OCT), OCT-angiography (OCTA) and fluorescein angiography (FA), is the important subject for ophthalmic. The use of such equipment continues to increase and retinal phantoms have also been developed to evaluate and modify its performance and image quality. In this presentation, we will show methods and results of a retinal phantom that can evaluate the optical performance of OCT, OCTA and FA. We implemented superficial vascular networks and full retinal layers which has curvature. We could obtain cross-sectional OCT images and en-face OCTA images using lab-made OCT system. In addition, FA image could also be obtained through sodium fluorescein dye injection.
We developed an eye phantom that mimic retinal layers and blood vessels to evaluation of retinal OCT-angiography and fundus angiography. The phantom was made of polydimethylsiloxane and titanium dioxide using spin coater and microelectromechanical system (MEMS) technology.
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