Prof. Rubin Wang Profile

Prof. Rubin Wang

at Donghua Univ

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Proceedings Article | 25 May 2004 Paper

A kinetic model of NMDA ion channel under varying noise

Rubin Wang, Hao Chen, Zhikang Zhang

Proceedings Volume 5467, (2004) https://doi.org/10.1117/12.547033

KEYWORDS: Ion channels, Molecular machines, Molecules, Proteins, Motion models, Calcium, Transmitters, Bioenergetics, Systems modeling, Stochastic processes

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It is well known that when transmitters are applied to the postsynaptic membrane, the resulting depolarization is noisy that is due to the random opening and closing of the ion channels activated by the transmitters[1]. In other words, the energy of noise is associated with changes in ion channels. On the base of these ideas, we explore a model of relationship between NMDA (n-methyl-D-aspartate) ion channels and LTP (long-term synaptic potentiation). We have proved that NMDA ion channel and calcium-dependent protein kinases, which are the triggers for the inducement of LTP, could be regarded as “molecular machines”. In this system all of these molecules require energy and the energy of the system is supplied from the random motion of water molecules generated through heat energy of ATP hydrolysis[2]. So the appropriate framework to describe them comes from bioenergetics. Models of LTP previously reported are all on the macroscopic level [3-7]. Instead, we research a model at the molecular level by applying energy parameters [8].

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