Ferrimagnetic nanoparticles have been limited in in vivo application because nanoparticles aggregate due to its remanent
magnetization. Uniform-sized ferromagnetic iron oxide nanocubes with similar value of bulk saturated magnetization
were synthesized. Control of nanocubes’ size minimized their remanence. PEG-phospholipid encapsulation enabled
spacing to prevent the aggregation. As a result, water-dispersed single core ferrimagnetic iron oxide nanocubes were
successfully prepared and their r2 relaxivity was 761 s-1mM-1. It was very close to theoretical calculated value 800 s-1mM-1 in static dephasing regime. in vivo MR images were obtained after intravenous injection of 22 nm nanoparticles to a mouse. The MR signal of tumor site changed significantly. In this research, synthesized ferrimagnetic iron oxide nanocubes showed a superior T2 contrast effect and it would be able to improve the quality of early diagnosis and detection of tumor.
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