Spinal cord stimulators (SCSs), as a new type of implantable medical device, has been widely studied and applied to alleviate the pain that cannot be alleviated by traditional treatments. Although it is relatively effective in pain relief, the efficacy of this treatment and the safety of SCS remains challenges still. However, due to the limited studies, methodological weaknesses of previous clinical studies, and lack of exploration of the mechanism of pain control in spinal cord injury (SCI), its efficacy, benefit, and mechanism of action in SCI pain remain elusive. Hence, researchers have successfully developed emerging SCSs and improved them in line with the substantial performance testings. In this context, we firstly present the investigations on SCSs in terms of SCS methods, electrode materials, pulse generators, wearable parts, and the mechanisms of power supply. Secondly, a systematic overview of recent advances in SCSs and their impacts on therapeutic efficacy and safety is highlighted. Finally, the clinical manifestations and prospects of SCSs are discussed.
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