Fluorescence imaging has emerged as a valuable tool for clinical angiographic and cardiovascular imaging, allowing for visualization and quantification of biological processes. Among the range of fluorescence imaging windows, near-infrared (NIR) imaging has shown great promise as a non-invasive modality for angiographic and cardiovascular imaging. To overcome limitations associated with indocyanine green dye (ICG), we developed a biocompatible DNA-based platform for conjugation with ICG dyes and targeting moieties. The primary objective of this pilot study is to evaluate the efficacy of the DNA-ICG platform for contrast-enhanced NIR-II (>1250 nm) fluorescence imaging in a mouse model. Throughout the experiment, various organs were observed, including the heart, liver, spleen, caecum, and intestines. Notably, vascular structures in the tail, spinal column, and head remained visible for hours after the administration of the contrast agent. The DNA-ICG platform holds promise as an effective imaging tool for angiographic and cardiovascular studies.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.