Prof. Tymish Y. Ohulchanskyy Profile

Prof. Tymish Y. Ohulchanskyy

at Shenzhen Univ

SPIE Involvement:

Author

Publications (15)

Proceedings Article | 13 March 2024 Presentation

Synergistically enhanced cancer phototheranostics using multifunctional nanoplatforms

Tymish Ohulchanskyy

Proceedings Volume PC12843, PC128430D (2024) https://doi.org/10.1117/12.3008213

KEYWORDS: Cancer, Therapeutics, Photodynamic therapy, Tumors, Oncology, Tumor growth modeling, Toxicity, Therapeutic agents, Silica, Safety

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Proceedings Article | 13 March 2024 Poster

Near-infrared light at 808nm reduces β-amyloid-stimulated microglial toxicity and enhances survival of neurons in Alzheimer's disease in vitro model

Iuliia Golovynska, Yurii Stepanov, Renlong Zhang, Sergii Golovynskyi, Liudmyla Garmanchuk, Tymish Ohulchanskyy, Junle Qu

Proceedings Volume PC12826, PC128260E (2024) https://doi.org/10.1117/12.3002276

KEYWORDS: Neurons, Alzheimer disease, Toxicity, In vitro testing, Phototherapy, Phosphates, Neurodegeneration, Semiconductor lasers, Pathology, Nicotinamide adenine dinucleotide

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Proceedings Article | 13 March 2024 Presentation

Core-thermoresponsive shell polymeric nanoparticles loaded with imaging and therapeutic agents for biomedical applications

Tymish Ohulchanskyy, Ludmyla Vretik

Proceedings Volume PC12862, PC128620D (2024) https://doi.org/10.1117/12.3003772

KEYWORDS: Nanoparticles, Polymers, Biomedical optics, Therapeutic agents, Biomedical applications, Molecules, Fluorescence imaging, Copolymers, Cancer, Tumors

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Proceedings Article | 30 March 2023 Presentation

Revealing mechanisms of red and near infrared photobiomodulation through optical imaging of cell and animal models

Tymish Ohulchanskyy

Proceedings Volume 12380, 123800I (2023) https://doi.org/10.1117/12.2653122

KEYWORDS: Near infrared, Optical imaging, Animal model studies, Thermal modeling, Microscopy, Luminescence, In vivo imaging, In vitro testing, Imaging systems, Wound healing

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Proceedings Article | 17 March 2023 Presentation

Multifunctional biocompatible nanoplatforms for near infrared cancer theranostics (Conference Presentation)

Tymish Ohulchanskyy

Proceedings Volume PC12398, PC1239809 (2023) https://doi.org/10.1117/12.2653118

KEYWORDS: Near infrared, Cancer, Tumors, Luminescence, Photodynamic therapy, Optical imaging, Computed tomography, Tumor growth modeling, Toxicity, Tissue optics

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Proceedings Article | 14 March 2023 Presentation

Optimizing photobiomodulation in the in vitro and in vivo models towards effective therapy of Alzheimer's disease (Conference Presentation)

Hao Xu, Tymish Ohulchanskyy, Junle Qu

Proceedings Volume 12380, 1238009 (2023) https://doi.org/10.1117/12.2651226

KEYWORDS: In vivo imaging, In vitro testing, Alzheimer's disease, Microscopy, Luminescence, Light emitting diodes, Tissues, Near infrared, Visualization, Two photon imaging

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Proceedings Article | 30 May 2022 Presentation

Imaging near-infrared luminescent nanoformulations to guide drug delivery and photoinduced therapy

Tymish Ohulchanskyy

Proceedings Volume PC12147, PC121470B (2022) https://doi.org/10.1117/12.2622637

KEYWORDS: Near infrared, Optical imaging, Biomedical optics, Tissue optics, Phototherapy, Nanoparticles, Luminescence, Cancer, Short wave infrared radiation, Nanotechnology

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The field of biophotonics embraces biomedical applications of light, particularly in diagnostics (e.g., optical bioimaging) and therapeutics (e.g., light induced therapy) of cancer and other diseases. At the same time, the biomedical field has been greatly advancing through a nanotechnology, which offers a platform for targeted drug delivery and multimodal medical imaging. Merging nanotechnology and biophotonics approaches resulted in a development of multiple nanoplatforms combining optical diagnostic and phototherapeutic capabilities; optical imaging guided nanotherapeutics is among the most intensively developing directions in nanobiotechnology. In the last few years, we have been working on inorganic and organic nanomaterials for optical bioimaging and imaging guided phototherapy, along with a development of the advanced optical imaging modalities. This talk will present our recent results on development of heterogeneous nanoparticles that can be detected/ imaged/ differentiated in vitro and in vivo using near infrared (NIR) luminescence imaging. The proposed nanoplatforms comprise polymeric, lipid or protein nanoparticles along with rare earth ion doped fluoride nanocrystals, as well as their nanoblends with NIR fluorescent organic dyes and other functional small molecules, including molecular agents for chemo and photoinduced therapies of cancer. Spectral and temporal features of the photoluminescence from the developed nanoformulations allow for using them as imaging agents in hyperspectral, time-gated and luminescence lifetime imaging. While possessing the NIR imaging contrast and therapeutic functionality, the NIR emitting nanoformulations can also be garnished with other medical imaging modalities (e.g., computed tomography, CT, photoacoustic imaging, PAI), providing a single nanoagent for multiple imaging techniques and enabling the integration of cellular, tissue and whole body imaging. The talk will demonstrate examples of applications of nanoparticles as multimodal imaging guided therapeutic agents and conclude with a discussion on the challenges and opportunities in the domain of optically active nanoformulations for NIR imaging guided phototherapies of cancer and other diseases.

Proceedings Article | 10 April 2020 Presentation

Near-infrared phototheranostics: optical imaging and light induced therapy (Conference Presentation)

Tymish Ohulchanskyy

Proceedings Volume 11363, 113631A (2020) https://doi.org/10.1117/12.2553677

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Proceedings Article | 20 December 2019 Paper

Time-gated and lifetime-unmixed imaging of near- and short wave infrared photoluminescence from rare-earth ion doped nanoparticles

Roman Ziniuk, Artem Yakovliev, Junle Qu, Tymish Ohulchanskyy

Proceedings Volume 11209, 112095E (2019) https://doi.org/10.1117/12.2550166

KEYWORDS: Nanoparticles, Imaging systems, Cameras, Short wave infrared radiation, Luminescence, Software development, Ions, Infrared imaging, Tissues

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Proceedings Article | 20 November 2019 Paper

LED-based portable light source for photodynamic therapy

O. Chepurna, A. Grebinyk, Yu. Petrushko, S. Prylutska, S. Grebinyk, V. Yashchuk, O. Matyshevska, U. Ritter, T. Dandekar, M. Frohme, J. Qu, T. Ohulchanskyy

Proceedings Volume 11190, 111901A (2019) https://doi.org/10.1117/12.2541774

KEYWORDS: Light emitting diodes, Photodynamic therapy, Light sources, In vitro testing, Cancer, 3D modeling, 3D printing, Cell death, Fullerenes, Biotechnology

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Proceedings Article | 4 March 2019 Presentation

Nanoscopic optical imaging: Temporal resolution, new materials, and biological applications (Conference Presentation)

Luwei Wang, Wei Yan, Zhigang Yang, Svitlana Levchenko, Tymish Ohulchanskyy, Junle Qu

Proceedings Volume 10907, 1090707 (2019) https://doi.org/10.1117/12.2514678

KEYWORDS: Optical imaging, Super resolution, Temporal resolution, Live cell imaging, Stimulated emission depletion microscopy, Microscopy, Fluorescence lifetime imaging, Optical microscopy, Spatial resolution, Reconstruction algorithms

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Proceedings Article | 15 November 2018 Paper

Hyperspectral imaging of rare-earth doped nanoparticles emitting in near- and short-wave infrared regions

Artem Yakovliev, Roman Ziniuk, Junle Qu, Tymish Ohulchanskyy

Proceedings Volume 10964, 109646J (2018) https://doi.org/10.1117/12.2506542

KEYWORDS: Nanoparticles, Tissues, Hyperspectral imaging, Imaging systems, Short wave infrared radiation, Cameras, Software development, Scattering, Data acquisition, Signal detection

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SPIE Journal Paper | 5 June 2012 Open Access

In situ gold nanoparticles formation: contrast agent for dental optical coherence tomography

Ana Karla Braz, Renato de Araujo, Tymish Ohulchanskyy, Shoba Shukla, Earl Bergey, Anderson S. Gomes, Paras Prasad

JBO, Vol. 17, Issue 06, 066003, (June 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.6.066003

KEYWORDS: Gold, Nanoparticles, Optical coherence tomography, Adhesives, Scanning electron microscopy, Teeth, Collagen, Biomedical optics, Tissues, 3D image processing

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Proceedings Article | 13 July 2009 Paper

Multifunctional ORMOSIL and PAA nanoparticles

Anurag Gupta, K. V. Rao, Paula Pera, Shouyan Wang, Joseph Missert, Tymish Ohulchanskyy, Indrajit Roy, Janet Morgan, Paras Prasad, Raoul Kopelman, Ravindra Pandey

Proceedings Volume 7380, 73805H (2009) https://doi.org/10.1117/12.822939

KEYWORDS: Photodynamic therapy, Oxygen, Silicon, Picosecond phenomena, Nanoparticles, Tumors, Cancer, Absorption, Therapeutic agents, Transmission electron microscopy

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Proceedings Article | 14 March 2005 Paper

Laser tweezer technique for study of gelation process

Andrey Kuzmin, Aliaksandr Kachynski, Tymish Ohulchanskyy, Indrajit Roy, Stanley Bruckenstein, Paras Prasad

Proceedings Volume 5736, (2005) https://doi.org/10.1117/12.588679

KEYWORDS: Sol-gels, Optical tweezers, Luminescence, Fluorescence anisotropy, Quantum efficiency, Rhodium, Liquids, Optical trapping, Capillaries, Laser applications

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