Real-time temperature monitoring inside living organisms provides a direct measure of their biological activities, such as homeostatic thermoregulation and energy metabolism. Here, using quantum nanothermometers based on optically accessible electron spins of nitrogen vacancy centers in nanodiamonds, we demonstrate in vivo real-time temperature monitoring inside nematode worms. We developed a thermometry system that can measure the temperatures of mobile nanodiamonds inside the worms with a precision of ± 0.22 oC. Using this system, we determined the increase in temperature based on the thermogenic responses of the worms during the chemical stimuli of mitochondrial uncouplers.
Remote acceleration of a molecular recognition will open an avenue for the control of various biological functions.
Here, we have developed a new principle for the rapid macroscopic assembly based on the light-induced molecular
recognition via nanoparticles. Remarkably, as an application of this principle, we have demonstrated the submillimetre
network formation triggered by light-induced hybridization of zmol-level DNA within a few minutes. This finding will be
used for the rapid and highly sensitive genetic screening without fluorescent labeling.
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