Photo-mediate ultrasound therapy (PUT) is a new anti-vascular technique based on cavitation induced spallation, applies nanosecond laser pulses and ultrasound bursts simultaneously to promote cavitation activity to remove the blood vessel. However, the real time detection of cavitation to guide PUT in real time is still challenging. To better understand the spatial-temporal distribution of cavitation bubbles, we proposed to integrate Doppler optical coherence tomography (DOCT) combined PUT, where the DOCT was used to visualize shockwave-induced cavitation and monitor treatment response in real time. The addition of DOCT to PUT allows for quantitative prescreening and real time monitoring during treatment response, which can improve the safety and effectiveness of the therapy.
Photo-mediated Ultrasound Therapy (PUT) is a novel anti-vascular and agree-free technique, which can selectively remove blood vessels by promoting cavitation activity with a significantly lower amount of energy of ultrasound burst and nanosecond laser simultaneity when compared to energy level required by individual laser and ultrasound treatment therapies. We report the development of a high-speed PUT system with 50 kHz pulsed laser, decreasing the treatment time by a factor of 20. In addition, we combined it with optical coherence tomography angiography (OCTA) for real-time monitoring in vivo rabbit experiments. Based on quantitative prescreening and real-time monitoring of treatment response, this combination enables implementation of individualized treatment strategies.
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